{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:22Z","timestamp":1740126802258,"version":"3.37.3"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Objective\u2003Little data are available regarding erythropoietin (Epo) utilization patterns within neonatal intensive care units (NICUs). We sought to describe the trends in Epo utilization across a large cohort of U.S. NICUs.<\/jats:p><jats:p>Study Design\u2003This is a retrospective cohort study of infants discharged from 2008 to 2017 using the Pediatrix Clinical Data Warehouse.<\/jats:p><jats:p>Results\u2003We identified 704,159 eligible infants from 358 sites, of whom 9,749 (1.4%) had Epo exposure. For extremely low gestational age newborns (ELGANs), Epo exposure ranged from 7.6 to 13.5%. We found significant site variability in Epo utilization in ELGANs. Among the 299 NICUs caring for ELGANs during the study period, 184 (61.5%) never used Epo for this population, whereas 21 (7%) utilized Epo in 50% or more of eligible infants. Epo was initiated at a median of 25 days in ELGANs. For infants with hypoxic\u2013ischemic encephalopathy (HIE), Epo exposure remained \u22641% through 2014 then increased fourfold to 3.4% by 2017. The median day of Epo initiation was the day of birth for infants diagnosed with HIE.<\/jats:p><jats:p>Conclusion\u2003Epo is utilized in ELGANs more commonly than for other NICU populations. Utilization patterns appear to indicate the treatment of established anemia for ELGANs and more recently for neuroprotection in patients diagnosed with HIE.<\/jats:p>","DOI":"10.1055\/s-0039-3400981","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T08:40:07Z","timestamp":1576831207000},"page":"734-740","source":"Crossref","is-referenced-by-count":2,"title":["Utilization of Erythropoietin within the United States Neonatal Intensive Care Units from 2008 to 2017"],"prefix":"10.1055","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5970-6791","authenticated-orcid":false,"given":"Kaashif A.","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Pediatrix Medical Group of Texas\u2013San Antonio, San Antonio, Texas"},{"name":"Department of Pediatrics, Baylor College of Medicine, San Antonio, Texas"},{"name":"Center for Research, Education, Quality and Safety, MEDNAX, Sunrise, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica M.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Center for Clinical Effectiveness, Baylor Scott & White Health, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra E.","family":"Juul","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Washington, Seattle, Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin K.","family":"Ohls","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Utah, Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reese H.","family":"Clark","sequence":"additional","affiliation":[{"name":"Center for Research, Education, Quality and Safety, MEDNAX, Sunrise, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veeral N.","family":"Tolia","sequence":"additional","affiliation":[{"name":"Center for Research, Education, Quality and Safety, MEDNAX, Sunrise, Florida"},{"name":"Pediatrix Medical Group of Texas, Dallas, Texas"},{"name":"Department of Pediatrics, Baylor University Medical Center, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,12,13]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0022-3476(05)82217-6","article-title":"Recombinant human erythropoietin in the anemia of prematurity: results of a placebo-controlled pilot study","volume":"118","author":"K M Shannon","year":"1991","journal-title":"J Pediatr"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S0022-3476(05)80303-8","article-title":"Recombinant erythropoietin compared with erythrocyte transfusion in the treatment of anemia of 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