{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T12:19:28Z","timestamp":1781180368667,"version":"3.54.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003We evaluate diagnostic accuracy of the ARCHITECT chemiluminescent immunoassay (CIA) screening test in pregnancy, and evaluate pregnancy outcomes among screen-positive women.<\/jats:p><jats:p>\n          Study Design\u2003Samples from routine prenatal rapid plasma reagin (RPR) tests were collected between June 22 and August 18, 2017 and frozen. Samples were batch-tested with the Abbott ARCHITECT syphilis TP immunoassay (CIA, index test). We calculated sensitivity, specificity, predictive value, and false positivity. We compared pregnancy and neonatal outcomes among screen-positive women.<\/jats:p><jats:p>\n          Results\u2003Of 1,602 specimens, 35 (2.2%) were RPR\u2009+\u2009; of those, 24 (69%) were CIA\u2009+\/Treponema pallidum particle agglutination assay (TPPA)+ and 11 (31%) were CIA-\/TPPA-. Of 1,567 RPR- specimens, 14 (0.9%) were CIA\u2009+\u2009; of those, 13 (93%) were TPPA\u2009+\u2009, and one (7%) had a false positive CIA test. Sensitivity of the CIA (95% CI) was 100% (90.5\u2013100%), specificity 99.9% (99.6\u2013100%), positive predictive value 97.4% (86.2\u201399.9%), and false positive rate 0.06% (0.002\u20130.4%) for current or past syphilis. Among 37 CIA\u2009+\/TPPA+ women, seven (19%) had RPR-negative status (Group 1), 11 (30%) had previously treated syphilis (Group 2), and 19 (51%) had active infection (Group 3). One stillbirth occurred in a woman with early, active syphilis identified at delivery; no adverse perinatal outcomes occurred among women in Groups 1 or 2.<\/jats:p><jats:p>\n          Conclusion\u2003The ARCHITECT syphilis TP immunoassay accurately diagnoses current or past syphilis in pregnancy. Clinical history and staging remain essential using a reverse algorithm.<\/jats:p>","DOI":"10.1055\/s-0039-3400994","type":"journal-article","created":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T18:36:08Z","timestamp":1578335768000},"page":"112-118","source":"Crossref","is-referenced-by-count":9,"title":["Abbott ARCHITECT Syphilis TP Chemiluminescent Immunoassay Accurately Diagnoses Past or Current Syphilis in Pregnancy"],"prefix":"10.1055","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4060-2685","authenticated-orcid":false,"given":"Emily H.","family":"Adhikari","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ithiel J.","family":"Frame","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas"},{"name":"Department of Pathology, Parkland Health and Hospital System, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas"},{"name":"Department of Pathology, Parkland Health and Hospital System, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rizwana","family":"Fatabhoy","sequence":"additional","affiliation":[{"name":"Department of Pathology, Parkland Health and Hospital System, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda L.","family":"Strickland","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas"},{"name":"Department of Pathology, Parkland Health and Hospital System, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominick","family":"Cavuoti","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald D.","family":"McIntire","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita M.","family":"Hollaway","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,1,6]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-3400994.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T18:36:37Z","timestamp":1578335797000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-3400994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":0,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2020,1,6]]},"published-print":{"date-parts":[[2020,1]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-3400994","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]}}}