{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:56:28Z","timestamp":1777416988385,"version":"3.51.4"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"06","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No. 81672268"],"award-info":[{"award-number":["No. 81672268"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003This study was aimed to describe a new localization technique developed using medical glue and methylene blue dye, and characterized the localization results and postoperative outcome to evaluate its safety and usefulness.<\/jats:p><jats:p>\n          Methods\u2003This retrospective study was conducted at our center from January 2016 to April 2018. Totally 346 consecutive patients with 383 nodules who underwent preoperative computed tomography (CT)-guided medical glue and methylene blue dye localization, followed by lung resection, were enrolled in this study.<\/jats:p><jats:p>\n          Results\u2003Mean nodule size was 7.7\u2009\u00b1\u20093.7\u2009mm (range: 2\u201330\u2009mm), with a mean depth from pleura or fissure of 9.4\u2009\u00b1\u20099.3\u2009mm (range: 0\u201360\u2009mm). The success rate of CT-guided localization for pulmonary nodules was 99.5% (381\/383) of the nodules. Localization-related complications included mild pneumothorax in 16 (4.6%) patients, mild hemothorax in 7 (2.0%) patients, and hemoptysis in 1 (0.3%) patient. Pleural reaction occurred in 7 (2.0%) and pain in 25 (7.2%) patients. All 383 nodules were resected successfully, with conversion to thoracotomy only required in two patients for adhesion and calcification of lymph nodes. All patients recovered well postoperatively, with a short postoperative hospital stay (3.7\u2009\u00b1\u20092.0 days) and a low complication rate (2.6%, 9\/346).<\/jats:p><jats:p>\n          Conclusion\u2003CT-guided medical glue and methylene blue dye localization prior to video-assisted thoracoscopic surgery (VATS) lung resection was a novel, safe, and technically feasible method, with a high-technical success rate and a low-complication rate. It allowed surgeons to easily locate and detect the nodules and estimate the surgical margin.<\/jats:p>","DOI":"10.1055\/s-0039-3400999","type":"journal-article","created":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T23:33:10Z","timestamp":1583105590000},"page":"525-532","source":"Crossref","is-referenced-by-count":11,"title":["Preoperative Computed Tomography-Guided Localization for Pulmonary Nodules with Glue and Dye"],"prefix":"10.1055","volume":"68","author":[{"given":"Tian","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Zhongshan Hospital Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Zhongshan Hospital Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengnan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Zhongshan Hospital Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Zhongshan Hospital Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Zhongshan Hospital Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingxiang","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Zhongshan Hospital Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Zhongshan Hospital Fudan University, Shanghai, 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