{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:56:11Z","timestamp":1785333371159,"version":"3.55.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"S 04","license":[{"start":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T00:00:00Z","timestamp":1577750400000},"content-version":"vor","delay-in-days":30,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac cardiovasc Surg"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Neonates undergoing surgery for complex congenital heart disease are at risk of developmental impairment. Hypoxic\u2013ischemic brain injury might be a contributing factor. We aimed to investigate the perioperative release of the astrocyte cytoskeleton component glial fibrillary acid protein and its relation to cerebral oxygenation.<\/jats:p><jats:p>\n          Methods\u2003Serum glial fibrillary acid protein levels were measured before and 0, 12, 24, and 48\u2009hours after surgery. Reference values were based on preoperative samples; concentrations above the 95th percentile were defined as elevated. Cerebral oxygenation was derived by near-infrared spectroscopy.<\/jats:p><jats:p>\n          Results\u2003Thirty-six neonates undergoing 38 surgeries utilizing cardiopulmonary bypass were enrolled (complete data available for 35 procedures). Glial fibrillary acid protein was elevated after 18 surgeries (arterial switch: 7\/12; Norwood: 5\/15; others: 6\/8; p\u2009=\u20090.144). Age at surgery was higher in cases with elevated serum levels (6 [4\u20137] vs. 4 [2\u20135] days, p\u2009=\u20090.009) and intraoperative cerebral oxygen saturation was lower (70\u2009\u00b1\u200910% vs. 77\u2009\u00b1\u20097%, p\u2009=\u20090.029). In cases with elevated postoperative glial fibrillary acid protein, preoperative cerebral oxygen saturation was lower for neonates undergoing the arterial switch operation (55\u2009\u00b1\u20099% vs. 64\u2009\u00b1\u20094%, p\u2009=\u20090.048) and age at surgery was higher for neonates with a Norwood procedure (7 [6\u20138] vs. 5 [4\u20136] days, p\u2009=\u20090.028).<\/jats:p><jats:p>\n          Conclusions\u2003Glial fibrillary acid protein was elevated after \u223c50% of neonatal cardiac surgeries and was related to cerebral oxygenation and older age at surgery. The potential value as a biomarker for cerebral injury after neonatal cardiac surgery warrants further investigation; in particular, the association with neurodevelopmental outcome needs to be determined.<\/jats:p>","DOI":"10.1055\/s-0039-3401793","type":"journal-article","created":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T20:06:35Z","timestamp":1577822795000},"page":"e11-e18","source":"Crossref","is-referenced-by-count":4,"special_numbering":"S","title":["Glial Fibrillary Acid Protein and Cerebral Oxygenation in Neonates Undergoing Cardiac Surgery"],"prefix":"10.1055","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1575-2865","authenticated-orcid":false,"given":"Jan Hinnerk","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease and Pediatric Cardiology, University Hospital Schleswig-Holstein\u2014Campus Kiel, Kiel, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), partner site Hamburg\/Kiel\/L\u00fcbeck, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Kissner","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease and Pediatric Cardiology, University Hospital Schleswig-Holstein\u2014Campus Kiel, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guranda","family":"Chitadze","sequence":"additional","affiliation":[{"name":"Institute of Immunology, University Hospital Schleswig-Holstein\u2014Campus Kiel, Kiel, Schleswig-Holstein, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Logoteta","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease and Pediatric Cardiology, University Hospital Schleswig-Holstein\u2014Campus Kiel, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease and Pediatric Cardiology, University Hospital Schleswig-Holstein\u2014Campus Kiel, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"D\u00fctschke","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein - Campus Kiel, Kiel, Schleswig-Holstein, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Attmann","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Hospital Schleswig-Holstein - Campus Kiel, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Scheewe","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Hospital Schleswig-Holstein - Campus Kiel, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Heiner","family":"Kramer","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease and Pediatric Cardiology, University Hospital Schleswig-Holstein\u2014Campus Kiel, Kiel, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), partner site Hamburg\/Kiel\/L\u00fcbeck, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,12,31]]},"container-title":["The Thoracic and Cardiovascular Surgeon"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-3401793.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T18:52:02Z","timestamp":1577991122000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-3401793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":0,"journal-issue":{"issue":"S 04","published-online":{"date-parts":[[2019,11,1]]},"published-print":{"date-parts":[[2019,12]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-3401793","relation":{},"ISSN":["0171-6425","1439-1902"],"issn-type":[{"value":"0171-6425","type":"print"},{"value":"1439-1902","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12]]}}}