{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T06:45:21Z","timestamp":1775889921901,"version":"3.50.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropediatrics"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Seventeen-day-old twins were hospitalized for neonatal herpes simplex virus 1 (HSV-1) with central nervous system disease and internal capsule and thalamic lesions on magnetic resonance imaging (MRI). They were treated with the usual intravenous (IV) treatment and oral therapy for 6 months. The clinical course was good in both children with negative HSV polymerase chain reaction on completion of IV therapy. The neurological condition recurred in one child with new radiological lesions at 7 months of age, 2 weeks after discontinuation of oral treatment. Cerebral lesions highlighted on the MRI scan are specific to the neonatal period and impact long-term prognosis. The likely genetic predisposition in this case is interesting and requires further investigation. In addition, this case raises questions about the duration of oral acyclovir suppressive therapy.<\/jats:p>","DOI":"10.1055\/s-0039-3402011","type":"journal-article","created":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T23:34:07Z","timestamp":1577748847000},"page":"221-224","source":"Crossref","is-referenced-by-count":6,"title":["Neonatal Herpes Simplex Virus-1 Recurrence with Central Nervous System Disease in Twins after Completion of a Six-Month Course of Suppressive Therapy: Case Report"],"prefix":"10.1055","volume":"51","author":[{"given":"Anthony","family":"Grondin","sequence":"additional","affiliation":[{"name":"Neonatal Unit, Department of Paediatrics, CHU of Reunion Island, Northern Hospital Group, Saint-Denis, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elo\u00efse","family":"Baudou","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Paediatrics, CHU of Toulouse Purpan, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marl\u00e8ne","family":"Pasquet","sequence":"additional","affiliation":[{"name":"Immunology Unit, Department of Paediatrics, CHU of Toulouse Purpan, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Pelluau","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care, Department of Paediatrics, CHU of Toulouse Purpan, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karim","family":"Jamal-Bey","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Department of Paediatrics, CHU of Reunion Island, Southern Hospital Group, R\u00e9union, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cile","family":"Bermot","sequence":"additional","affiliation":[{"name":"Department of Radiology, Georges POMPIDOU Hospital, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederic","family":"Villega","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Paediatrics, CHU of Bordeaux, Aquitaine, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Cheuret","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Paediatrics, CHU of Toulouse Purpan, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,12,30]]},"container-title":["Neuropediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-3402011.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T22:41:51Z","timestamp":1589582511000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-3402011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,30]]},"references-count":0,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2020,5,15]]},"published-print":{"date-parts":[[2020,6]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-3402011","relation":{},"ISSN":["0174-304X","1439-1899"],"issn-type":[{"value":"0174-304X","type":"print"},{"value":"1439-1899","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,30]]}}}