{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T12:39:47Z","timestamp":1766407187460},"reference-count":48,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Knee Surg"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hylan G-F 20 viscosupplementation can be used to treat knee osteoarthritis pain. This study evaluated time to knee arthroplasty (KA), KA risk factors, and health care resource utilization in patients aged \u226518 years with claims in the Optum Clinformatics Data Mart database (2006\u20132016) for knee osteoarthritis treated with at least one course of hylan G-F 20. Kaplan\u2013Meier analysis estimated KA risk from osteoarthritis diagnosis and first hylan G-F 20 treatment. KA risk factors were determined using multivariate Cox regression. Among 62,033 patients treated with hylan G-F 20 and\/or hylan G-F 20 single intra-articular injection, 60 to 64% did not undergo KA 8 years following first injection. KA risk factors from time of osteoarthritis diagnosis and first hylan G-F 20 treatment were similar: increased age, fewer comorbidities, fewer hylan G-F 20 treatments, female sex, and no ultrasound\/fluoroscopy for injection guidance. Patients who underwent KA versus those who did not had more office visits and claims for opioids, nonsteroidal anti-inflammatory drugs, and physical therapy. Patients less likely to undergo KA were younger (&lt;40 years), had more comorbidities, received more courses of hylan G-F 20, were males, or received ultrasound\/fluoroscopic injection guidance. Patients who did not receive KA versus those who did used fewer health care resources.<\/jats:p>","DOI":"10.1055\/s-0039-3402043","type":"journal-article","created":{"date-parts":[[2019,12,24]],"date-time":"2019-12-24T23:41:35Z","timestamp":1577230895000},"page":"886-897","source":"Crossref","is-referenced-by-count":5,"title":["Factors Associated with Knee Arthroplasty in a Knee Osteoarthritis Patient Cohort Treated with Intra-articular Injections of Hylan G-F 20"],"prefix":"10.1055","volume":"34","author":[{"given":"Kevin","family":"Ong","sequence":"additional","affiliation":[{"name":"Exponent, Inc., Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmund","family":"Lau","sequence":"additional","affiliation":[{"name":"Exponent, Inc., Biomedical Engineering, Menlo Park, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Runa","sequence":"additional","affiliation":[{"name":"Exponent, Inc., Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Daley","sequence":"additional","affiliation":[{"name":"Sanofi, Inc., Bridgewater Township, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy","family":"Altman","sequence":"additional","affiliation":[{"name":"Division of Rheumatology and Immunology, Department of Medicine, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,12,24]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/acr.22721","article-title":"Alternative methods for defining osteoarthritis and the impact on estimating prevalence in a US population-based survey","volume":"68","author":"M G Cisternas","year":"2016","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"06","key":"ref2","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1001\/jama.2013.13805","article-title":"The state of US health, 1990-2010: burden of diseases, injuries, and risk factors","volume":"310","author":"C J Murray","year":"2013","journal-title":"JAMA"},{"issue":"04","key":"ref3","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/BF03324607","article-title":"Health-related quality of life in older adults with symptomatic hip and knee osteoarthritis: a comparison with matched healthy controls","volume":"17","author":"F Salaffi","year":"2005","journal-title":"Aging Clin Exp Res"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3111\/13696998.2011.594347","article-title":"Clinical comorbidities, treatment patterns, and direct medical costs of patients with osteoarthritis in usual care: a retrospective claims database analysis","volume":"14","author":"M Gore","year":"2011","journal-title":"J Med Econ"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/art.23176","article-title":"Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. 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