{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:02:49Z","timestamp":1793106169731,"version":"4.5.0"},"reference-count":57,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T00:00:00Z","timestamp":1587945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ortop (Sao Paulo)"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Resumo<\/jats:title><jats:p>As \u00falceras e infec\u00e7\u00f5es s\u00e3o complica\u00e7\u00f5es comuns nos p\u00e9s dos pacientes diab\u00e9ticos que j\u00e1 se encontram na fase tardia desta doen\u00e7a sist\u00eamica que se tornou uma verdadeira epidemia do mundo moderno. Neste grupo espec\u00edfico de pacientes, s\u00e3o as infec\u00e7\u00f5es que constituem o principal fator envolvido na sequ\u00eancia de eventos que resultam na amputa\u00e7\u00e3o do membro inferior. A neuropatia perif\u00e9rica (NC) constitui fator determinante na perda da sensibilidade protetora dos p\u00e9s na fase tardia da doen\u00e7a e, por sua vez, favorece o desenvolvimento das \u00falceras plantares de press\u00e3o (UPP) e a destrui\u00e7\u00e3o osteoarticular causado pela neuroartropatia de Charcot (NC). A obesidade, a doen\u00e7a arterial perif\u00e9rica (DAP) e a defici\u00eancia no sistema imunol\u00f3gico devida aos dist\u00farbios metab\u00f3licos do diabetes desempenham papel adicional importante na morbidade desta doen\u00e7a, principalmente no que se refere \u00e0 amputa\u00e7\u00e3o dos membros inferiores. \u00c9 importante para o m\u00e9dico ortopedista compreender que para tentar evitar estas complica\u00e7\u00f5es que costumam resultar na amputa\u00e7\u00e3o da extremidade \u00e9 necess\u00e1rio estabelecer estrat\u00e9gias de preven\u00e7\u00e3o direcionadas, principalmente, para a educa\u00e7\u00e3o do paciente diab\u00e9tico e tamb\u00e9m para medidas protetoras profil\u00e1ticas.<\/jats:p>","DOI":"10.1055\/s-0039-3402462","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T23:06:33Z","timestamp":1588028793000},"page":"389-396","source":"Crossref","is-referenced-by-count":19,"title":["P\u00e9 diab\u00e9tico. 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