{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:22:38Z","timestamp":1789582958203,"version":"build-2803163510"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003This study aims to estimate the association between abnormal placental histopathology, fetal growth restriction (FGR), and preeclampsia (PEC) in twin pregnancies.<\/jats:p><jats:p>\n          Study Design\u2003Retrospective cohort study of women with diamniotic twin pregnancies with live births at \u226524 weeks of gestation and available placental pathology. Findings were compared between women with and without FGR, which was defined as a birthweight &lt;10th percentile, using singleton and twin growth curves, and those with and without PEC. The primary study outcome was a composite of abnormal placental histopathology. Chi-square, Fisher's exact, and Student's t-tests were used for analysis.<\/jats:p><jats:p>\n          Results\u2003Among 859 patients with diamniotic twins, 806 (93.8%) had placental pathology. A total of 422 (52.4%) women had at least one twin with FGR, using a singleton growth curve. FGR affected 136 (16.9%) pregnancies when a twin growth curve was applied. There was no significant difference in composite outcome between groups, using either growth curve (45.5 vs. 44.8%, p\u2009=\u20090.84; adjusted odds ratio (aOR): 1.06, 95% CI: 0.79\u20131.40 and 52.2 vs. 43.7%, p\u2009=\u20090.07; aOR: 1.44, 95% CI: 0.90\u20132.10). A total of 122 of 789 (15.5%) patients developed PEC. There was no significant difference in composite outcome between patients with and without PEC (41.8 vs. 45.4%, p\u2009=\u20090.46; aOR: 0.79, 95% CI: 0.53\u20131.18).<\/jats:p><jats:p>\n          Conclusion\u2003In twin pregnancies, FGR and PEC are not associated with abnormal placental histopathology. This suggests that the pathologic placental manifestations of these conditions may differ in twins and include factors other than those commonly described in singletons.<\/jats:p>","DOI":"10.1055\/s-0039-3402716","type":"journal-article","created":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:38:28Z","timestamp":1577839108000},"page":"784-790","source":"Crossref","is-referenced-by-count":12,"title":["The Association between Placental Histopathology, Fetal Growth Restriction, and Preeclampsia in Twin Pregnancies"],"prefix":"10.1055","volume":"38","author":[{"given":"Kathy C.","family":"Matthews","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, New York Presbyterian\u2013Weill Cornell Medicine, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan S.","family":"Fox","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York"},{"name":"Maternal Fetal Medicine Associates, PLLC, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Rebarber","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York"},{"name":"Maternal Fetal Medicine Associates, PLLC, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,12,31]]},"reference":[{"issue":"08","key":"ref1","first-page":"1","article-title":"Births: final data for 2017","volume":"67","author":"J A Martin","year":"2018","journal-title":"Natl Vital Stat Rep"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.ss6804a1","article-title":"Assisted reproductive technology surveillance - United States, 2016","volume":"68","author":"S Sunderam","year":"2019","journal-title":"MMWR Surveill Summ"},{"issue":"02","key":"ref3","doi-asserted-by":"crossref","first-page":"B2","DOI":"10.1016\/j.ajog.2019.04.013","article-title":"SMFM special statement: state of the science on multifetal gestations: unique considerations and importance","volume":"221","author":"K L Grantz","year":"2019","journal-title":"Am J Obstet Gynecol"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1097\/00006250-200410000-00046","article-title":"ACOG practice bulletin #56: multiple gestation: complicated twin, triplet, and high-order multifetal pregnancy","volume":"104","author":"American College of Obstetricians and Gynecologists Committee on Practice Bulletins-Obstetrics; 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