{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:01:46Z","timestamp":1761490906156,"version":"3.37.3"},"reference-count":16,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003This study aims to investigate neonatal outcomes of triplet gestations conceived via in vitro fertilization (IVF) compared with those not conceived by IVF.<\/jats:p><jats:p>\n          Study Design\u2003This is a retrospective cohort study of women who delivered a triplet gestation \u226524 weeks at a large academic center (2005\u20132016). Women with unknown mode of conception were excluded. Women who conceived via IVF were compared with those conceiving spontaneously or through non-IVF fertility treatments. The primary outcome was a composite severe neonatal morbidity (respiratory distress syndrome, necrotizing enterocolitis, severe intraventricular hemorrhage, retinopathy of prematurity, neonatal sepsis, or death). Bivariate comparisons were made by mode of conception and unadjusted generalized estimating equations were used to estimate odds ratios (OR) after accounting for the clustering of neonate by mother.<\/jats:p><jats:p>\n          Results\u2003Among 82 women included in this analysis, 51 (62%) conceived via IVF. Women who conceived via IVF were older (35.2 vs. 30.7, p\u2009&lt;\u20090.001) and more likely to be of non-Hispanic white race\/ethnicity (91.8 vs. 70.0%, p\u2009&lt;\u20090.01) and married (100 vs. 90.0%, p\u2009=\u20090.02) when compared with women who did not conceive via IVF. Although women who conceived via IVF delivered at an earlier gestational age than those who did not (32.9\u2009\u00b1\u20093.0 vs. 33.7\u2009\u00b1\u20092.6 weeks, p\u2009=\u20090.02), there was no significant difference in composite neonatal morbidity (34.0 vs. 28.0%, p\u2009=\u20090.32; OR: 1.33, 95% CI: 0.60\u20132.91). Additionally, there were no significant differences between the groups with regard to other neonatal outcomes examined, including fetal growth restriction, birthweight, umbilical artery pH &lt;7, neonatal intensive care unit admissions, duration in the NICU, need for mechanical ventilation, or duration of mechanical ventilation.<\/jats:p><jats:p>\n          Conclusion\u2003Neonatal outcomes among triplet gestations did not differ by IVF in this well-characterized, single-center cohort.<\/jats:p>","DOI":"10.1055\/s-0039-3402720","type":"journal-article","created":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T23:52:44Z","timestamp":1578441164000},"page":"810-815","source":"Crossref","is-referenced-by-count":4,"title":["Neonatal Outcomes of Triplet Pregnancies Conceived via In Vitro Fertilization versus Other Methods of Conception"],"prefix":"10.1055","volume":"38","author":[{"given":"Nevert","family":"Badreldin","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle A.","family":"Peress","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn M.","family":"Yee","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4837-8059","authenticated-orcid":false,"given":"Ashley N.","family":"Battarbee","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, The University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,1,7]]},"reference":[{"issue":"09","key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.ss6909a1","article-title":"Assisted reproductive technology surveillance\u2013United States, 2010","volume":"62","author":"S Sunderam","year":"2013","journal-title":"MMWR Surveill Summ"},{"issue":"23","key":"ref2","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1056\/NEJMoa1301467","article-title":"Fertility treatments and multiple births in the United States","volume":"369","author":"A D Kulkarni","year":"2013","journal-title":"N Engl J Med"},{"issue":"01","key":"ref3","first-page":"1","article-title":"Births: final data for 2015","volume":"66","author":"J A Martin","year":"2017","journal-title":"Natl Vital Stat Rep"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1542\/peds.2014-4075","article-title":"Trends in morbidity and mortality of extremely preterm multiple gestation newborns","volume":"136","author":"K T Yeo","year":"2015","journal-title":"Pediatrics"},{"issue":"08","key":"ref5","first-page":"661","article-title":"The contribution of singletons, twins and triplets to low birth weight, infant mortality and handicap in the United States","volume":"37","author":"B Luke","year":"1992","journal-title":"J Reprod Med"},{"issue":"03","key":"ref6","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/01.AOG.0000114989.84822.51","article-title":"Perinatal outcomes in singletons following in vitro fertilization: a meta-analysis","volume":"103","author":"R A Jackson","year":"2004","journal-title":"Obstet Gynecol"},{"issue":"03","key":"ref7","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1097\/AOG.0000000000001292","article-title":"Severe maternal morbidity and the use of assisted reproductive technology in Massachusetts","volume":"127","author":"C Belanoff","year":"2016","journal-title":"Obstet Gynecol"},{"issue":"01","key":"ref8","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ejogrb.2012.07.008","article-title":"Obstetric and neonatal outcomes of twin pregnancies conceived by assisted reproductive technology compared with twin pregnancies conceived spontaneously: a prospective follow-up study","volume":"165","author":"A Moini","year":"2012","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"01","key":"ref9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00000658-197801000-00001","article-title":"Neonatal necrotizing enterocolitis. 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