{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T10:01:23Z","timestamp":1771581683580,"version":"3.50.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003This study aimed to evaluate the association of ARCHITECT chemiluminescent immunoassay (CIA) signal strength (signal-to-cutoff [S\/CO] ratio), with maternal syphilis stage, rapid plasma reagin (RPR) reactivity, and congenital syphilis.<\/jats:p><jats:p>\n          Study Design\u2003A prospective observational study of reverse syphilis screening was conducted. Pregnant women were screened with CIA. Reactive CIA was reflexed to RPR; particle agglutination test (Treponema pallidum particle agglutination [TPPA]) was performed for CIA+\/RPR\u2212 results. Clinical staging with history and physical was performed, and disease stage was determined. Prior treatment was confirmed. We compared S\/CO ratio and neonatal outcomes among the following groups:<\/jats:p><jats:p>\n          Group 1: CIA+\/RPR+\/TPPA+ or CIA+\/RPR\u2212\/TPPA+ with active syphilis;<\/jats:p><jats:p>\n          Group 2: CIA+\/RPR\u2212\/TPPA+ or CIA+\/serofast RPR\/TPPA+, previously treated;<\/jats:p><jats:p>\n          Group 3: CIA+\/RPR\u2212\/TPPA+, no history of treatment or active disease;<\/jats:p><jats:p>\n          Group 4: CIA+\/RPR\u2212\/TPPA\u2212, false-positive CIA.<\/jats:p><jats:p>\n          Results\u2003A total of 144 women delivered with reactive CIA: 38 (26%) in Group 1, 69 (48%) in Group 2, 20 (14%) in Group 3, and 17 (12%) in Group 4. Mean (\u00b1standard deviation) S\/CO ratio was 18.3\u2009\u00b1\u20095.4, 12.1\u2009\u00b1\u20095.3, 9.1\u2009\u00b1\u20094.6, and 1.9\u2009\u00b1\u20090.8, respectively (p\u2009&lt;\u20090.001). Neonates with overt congenital syphilis occurred exclusively in Group 1.<\/jats:p><jats:p>\n          Conclusion\u2003Women with active syphilis based on treatment history, clinical staging, and laboratory indices have higher CIA S\/CO ratio and are more likely to deliver neonates with overt evidence of congenital syphilis.<\/jats:p>","DOI":"10.1055\/s-0039-3402748","type":"journal-article","created":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T23:52:44Z","timestamp":1578441164000},"page":"671-678","source":"Crossref","is-referenced-by-count":5,"title":["Syphilis Immunoassay Signal Strength Correlates with Active Infection in Pregnant Women"],"prefix":"10.1055","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2098-5188","authenticated-orcid":false,"given":"Amanda C.","family":"Zofkie","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, UT Southwestern Medical Center, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela R.","family":"Seasely","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, UT Southwestern Medical Center, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna","family":"Gaffney","sequence":"additional","affiliation":[{"name":"Microbiology Laboratory, Parkland Health and Hospital System, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa L.","family":"Rogers","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, UT Southwestern Medical Center, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald D.","family":"Mcintire","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, UT Southwestern Medical Center, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott W.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, UT Southwestern Medical Center, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4060-2685","authenticated-orcid":false,"given":"Emily H.","family":"Adhikari","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, UT Southwestern Medical Center, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,1,7]]},"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-3402748.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T22:38:57Z","timestamp":1590014337000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-3402748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,7]]},"references-count":0,"journal-issue":{"issue":"07","published-online":{"date-parts":[[2020,5,20]]},"published-print":{"date-parts":[[2020,6]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-3402748","relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,7]]}}}