{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:24:17Z","timestamp":1792099457981,"version":"4.4.0"},"reference-count":73,"publisher":"Georg Thieme Verlag KG","issue":"S 03","funder":[{"name":"Internal departmental funding"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg B Skull Base"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Objective\u2003The objective of this study is to describe the clinical presentation, tumor characteristics, natural history, and treatment patterns of sinonasal osteosarcoma.<\/jats:p><jats:p>Methods\u2003Fourteen patients who had been treated for osteosarcoma of the nasal cavity and paranasal sinuses at a tertiary care center were reviewed. In addition, a systematic review of the literature for osteosarcoma of the sinonasal cavity was performed.<\/jats:p><jats:p>Results\u2003In a systematic review, including 14 patients from the authors' institution, 53 total studies including 88 patients were assessed. Median follow-up was 18 months (interquartile range: 8\u201339 months). The most common presenting symptoms were facial mass or swelling (34%), and nasal obstruction (30%). The most common paranasal sinus involved by tumor was the maxillary sinus (64%), followed by the ethmoid sinuses (52%). The orbit (33%), dura (13%) and infratemporal fossa (10%) were the most common sites of local invasion. The majority of patients underwent surgery followed by adjuvant therapy (52.4%). Increasing age was associated with decreased overall survival rate (unit risk ratio [95% confidence interval (CI)]\u2009=\u20091.02 [1.003\u20131.043]; p\u2009=\u20090.0216) and T4 disease was associated with decreased disease-specific survival rate (hazard ratio [HR]\u2009=\u20092.87; p\u2009=\u20090.0495). The 2- and 5-year overall survival rates were 68 and 40%, respectively, while 2- and 5-year disease-specific survival rates were 71% and 44%, respectively.<\/jats:p><jats:p>Conclusion\u2003Sinonasal osteosarcomas are uncommon tumors and can pose a significant therapeutic challenge. Increasing age and T4 disease are associated with worse prognosis. This disease usually warrants consultation by a multidisciplinary team and consideration of multimodality therapy.<\/jats:p>","DOI":"10.1055\/s-0040-1701221","type":"journal-article","created":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T23:41:07Z","timestamp":1579909267000},"page":"e138-e147","source":"Crossref","is-referenced-by-count":6,"special_numbering":"S","title":["Sinonasal Osteosarcoma: Report of 14 New Cases and Systematic Review of the Literature"],"prefix":"10.1055","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4322-0751","authenticated-orcid":false,"given":"Christopher M.","family":"Low","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson R.","family":"Gruszczynski","sequence":"additional","affiliation":[{"name":"Mayo Clinic Alix School of Medicine, Mayo Clinic, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3398-0562","authenticated-orcid":false,"given":"Daniel L.","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey R.","family":"Janus","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan L.","family":"Kasperbauer","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn M.","family":"Van Abel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janalee K.","family":"Stokken","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8087-7870","authenticated-orcid":false,"given":"Jamie J.","family":"Van Gompel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, United States"},{"name":"Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Link","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, United States"},{"name":"Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garret","family":"Choby","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,1,24]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/00005537-199701000-00013","article-title":"Osteosarcoma of the head and neck: meta-analysis of nonrandomized studies","volume":"107","author":"R R Kassir","year":"1997","journal-title":"Laryngoscope"},{"key":"ref2","first-page":"3","volume-title":"The epidemiology of osteosarcoma","author":"G Ottaviani","year":"2009"},{"key":"ref3","volume-title":"SEER Cancer Statistics Review, 1975\u20132015","author":"A Noone","year":"2018"},{"issue":"26","key":"ref4","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1056\/NEJM198512263132605","article-title":"Osteosarcoma: fifteen years later","volume":"313","author":"A M Goorin","year":"1985","journal-title":"N Engl J Med"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hed.2880140102","article-title":"Head and neck sarcoma: report of the Head and Neck Sarcoma Registry","volume":"14","author":"H J Wanebo","year":"1992","journal-title":"Head Neck"},{"issue":"02","key":"ref6","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S1010-5182(05)80614-6","article-title":"Osteosarcoma of the craniofacial bones. 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