{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:31:49Z","timestamp":1757705509987,"version":"3.37.3"},"reference-count":48,"publisher":"Georg Thieme Verlag KG","issue":"09","funder":[{"name":"NICHD","award":["K23 HD071134\u201301A1"],"award-info":[{"award-number":["K23 HD071134\u201301A1"]}]},{"name":"Indiana Clinical and Translational Sciences Institute (Pediatric Project Development Team Funding","award":["UL1TR001108"],"award-info":[{"award-number":["UL1TR001108"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003This pilot study evaluated the relationship between maternal and neonatal R- and S-methadone and R- and S-2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) exposure and the severity of neonatal abstinence syndrome (NAS). The use of dried blood spots (DBS) as an alternative for plasma in assessing methadone and EDDP was also assessed.<\/jats:p><jats:p>\n          Study Design\u2003Women receiving methadone for medication assisted treatment of opioid use disorder during pregnancy were eligible for recruitment. Plasma and DBS samples were collected from mothers during labor, from cord blood, and from newborns during genetic screen. R-\/S-methadone and EDDP were measured by high-performance liquid chromatography tandem mass spectrometry (HPLC\/MS\/MS). Associations between methadone exposure, neonatal morphine requirements, and severity of NAS were examined.<\/jats:p><jats:p>\n          Results\u2003Twenty women and infants completed the study. Maternal methadone dose at delivery was 112\u2009mg\/day (range\u2009=\u200960\u2013180\u2009mg\/day). Sixteen neonates experienced NAS requiring morphine; three also required phenobarbital. Higher cord blood concentrations of R-methadone, R- and S-EDDP were associated with higher maximum doses of morphine (p\u2009&lt;\u20090.05).<\/jats:p><jats:p>\n          Conclusion\u2003Maternal methadone and cord blood concentration at delivery are variable and may be potential markers of neonatal abstinence syndrome.<\/jats:p>","DOI":"10.1055\/s-0040-1701505","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T01:12:05Z","timestamp":1581556325000},"page":"968-975","source":"Crossref","is-referenced-by-count":7,"title":["Stereoselective Analysis of Methadone and EDDP in Laboring Women and Neonates in Plasma and Dried Blood Spots and Association with Neonatal Abstinence Syndrome"],"prefix":"10.1055","volume":"38","author":[{"given":"Ingrid F.","family":"Metzger","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana"},{"name":"Department of Pharmacy, Faculty of Health Sciences, Universidade de Bras\u00edlia, Bras\u00edlia, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna E.","family":"Thomas","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy A.","family":"Evrard","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Jones","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea R.","family":"Masters","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Analytical Core-Indiana University Simon Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8379-0743","authenticated-orcid":false,"given":"David M.","family":"Haas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana"},{"name":"Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura S.","family":"Haneline","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6554-0695","authenticated-orcid":false,"given":"Sara K.","family":"Quinney","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana"},{"name":"Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,2,12]]},"reference":[{"issue":"08","key":"ref1","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/jp.2015.36","article-title":"Increasing incidence and geographic distribution of neonatal abstinence syndrome: United States 2009 to 2012","volume":"35","author":"S W Patrick","year":"2015","journal-title":"J Perinatol"},{"volume-title":"U.S. Department of Health and Human Services","year":"2017","key":"ref2"},{"issue":"18","key":"ref3","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1001\/jama.2012.3951","article-title":"Neonatal abstinence syndrome and associated health care expenditures: United States, 2000-2009","volume":"307","author":"S W Patrick","year":"2012","journal-title":"JAMA"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"e540","DOI":"10.1542\/peds.2011-3212","article-title":"Neonatal drug withdrawal","volume":"129","author":"M L Hudak","year":"2012","journal-title":"Pediatrics"},{"issue":"22","key":"ref5","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1056\/NEJMsa1500439","article-title":"Increasing incidence of the neonatal abstinence syndrome in U.S. neonatal ICUs","volume":"372","author":"V N Tolia","year":"2015","journal-title":"N Engl J Med"},{"issue":"05","key":"ref6","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1097\/AOG.0b013e318256496e","article-title":"ACOG committee opinion no. 524: opioid abuse, dependence, and addiction in pregnancy","volume":"119","year":"2012","journal-title":"Obstet Gynecol"},{"volume-title":"National Survey of Substance Abuse Treatment Services (N-SSATS): 2018. 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