{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:15:00Z","timestamp":1787004900662,"version":"build-2736575974"},"reference-count":42,"publisher":"Georg Thieme Verlag KG","issue":"10","funder":[{"DOI":"10.13039\/501100005994","name":"Lithuanian State Science and Studies Foundation","doi-asserted-by":"crossref","award":["2008\u201304\u201307 No. T-101\/08"],"award-info":[{"award-number":["2008\u201304\u201307 No. T-101\/08"]}],"id":[{"id":"10.13039\/501100005994","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Objective\u2003The aim was to identify the critical levels of interleukin-6 (IL-6), tumor necrosis factor-\u03b1 (TNF-\u03b1), and vascular endothelial growth factor-A in umbilical cord blood that could be used as markers for predicting the central nervous system (CNS) damage and retinopathy of prematurity (ROP) in preterm infants.<\/jats:p>\n                  <jats:p>Study Design\u2003A total of 158 preterm infants, born at 22 to 34 weeks of gestation, were evaluated in the first week after birth and at 36 to 37 weeks of postconceptual age.<\/jats:p>\n                  <jats:p>Results\u2003A significant relationship between CNS changes and concentrations of IL-6 (p\u2009&lt;\u20090.001) and TNF-\u03b1 (p\u2009&lt;\u20090.001) in umbilical cord blood at 22 to 34 weeks of gestation was determined. The concentration of IL-6 &gt;13.0 pg\/mL predicts significant CNS damages in 36 to 37-week infants (p\u2009=\u20090.013). ROP was diagnosed in 24.8% infants (n\u2009=\u2009149). It was detected that the levels of TNF-\u03b1 &gt;116.4 pg\/mL (p\u2009&lt;\u20090.001) and IL-6 &gt;13.0 pg\/mL (p\u2009&lt;\u20090.05) in umbilical cord blood could predict 2 to 3\/3 to 4 stages of ROP.<\/jats:p>\n                  <jats:p>Conclusion\u2003Critical values of IL-6 and TNF-\u03b1 in predicting \u2265grade III intraventricular hemorrhage in the early adaptation and in predicting marked CNS damages and severe ROP stages in the later adaptation of preterm infants were determined.<\/jats:p>","DOI":"10.1055\/s-0040-1701508","type":"journal-article","created":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T20:12:05Z","timestamp":1581538325000},"page":"1036-1041","source":"Crossref","is-referenced-by-count":12,"title":["Umbilical Blood Levels of IL-6 and TNF-\u03b1 as Predictors of the Central Nervous System Damage and Retinopathy in Preterm Infants"],"prefix":"10.1055","volume":"38","author":[{"given":"Daiva","family":"Bartkevi\u010dien\u0117","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Centre of Obstetrics and Gynecology, Clinic of Obstetrics and Gynecology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrida","family":"Pilypien\u0117","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Centre of Obstetrics and Gynecology, Clinic of Obstetrics and Gynecology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2976-0682","authenticated-orcid":false,"given":"Danielius","family":"Serapinas","sequence":"additional","affiliation":[{"name":"Department of Psychology, Institute of Psychology, Mykolas Romeris University, Vilnius, Lithuania"},{"name":"Department of Family Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigita","family":"Vaigauskait\u0117","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Centre of Obstetrics and Gynecology, Clinic of Obstetrics and Gynecology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasa Aurelija","family":"Vankevi\u010di\u016bt\u0117","sequence":"additional","affiliation":[{"name":"Department of Dermatovenereology, Clinic of Infectious Diseases and Dermatovenerology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u0117","family":"Bartkevi\u010di\u016bt\u0117","sequence":"additional","affiliation":[{"name":"Department of Dermatovenereology, Clinic of Infectious Diseases and Dermatovenerology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ieva","family":"Narkevi\u010di\u016bt\u0117","sequence":"additional","affiliation":[{"name":"Department of Immunology, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena","family":"Dumalakien\u0117","sequence":"additional","affiliation":[{"name":"Department of Immunology, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,2,12]]},"reference":[{"issue":"09","key":"ref1","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1177\/0883073809338066","article-title":"Fetal inflammatory response and brain injury in the preterm newborn","volume":"24","author":"S Malaeb","year":"2009","journal-title":"J Child 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