{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T20:15:43Z","timestamp":1780431343926,"version":"3.54.1"},"reference-count":24,"publisher":"Scientific Scholar","license":[{"start":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T00:00:00Z","timestamp":1582156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ruralneuropractice.com"],"crossmark-restriction":true},"short-container-title":["JNRP"],"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p>\n<jats:bold>Objective<\/jats:bold>\u2003To assess lower urinary tract symptoms (LUTSs) in patients with neuromyelitis optica spectrum disorders (NMOSDs) and bladder dysfunction through urodynamics (filling and voiding phase of cystometrography) and management based on findings.<\/jats:p>\n<jats:p>\n<jats:bold>Patients and Methods<\/jats:bold>\u2003The study included 42 (34 females) patients admitted to the rehabilitation department. Neurologic evaluation was performed and severity of myelitis was assessed using the American Spinal Injury Association Impairment Scale. All patients underwent urodynamics, and management was based on the findings.<\/jats:p>\n<jats:p>\n<jats:bold>Results<\/jats:bold>\u2003Mean age was 34.5 years (range: 11\u201364 years; standard deviation: 13.1). Twenty-three (54.8%) patients had a first episode of myelitis, whereas 19 patients had relapses (number of episodes varying from 2 to 7). Eleven (26%) patients had increased frequency, 16 (37%) had urgency, 12 (28%) had urge incontinence, 8 (18.6%) had stress incontinence, 22 (52.4%) had nocturia, 31 (72%) had retention of urine, 22 (52.4%) had incomplete evacuation, and 14 (33.3%) patients had mixed urinary complaints. The common urodynamic findings were neurogenic detrusor overactivity (NDO) with detrusor-sphincter dyssynergia (DSD) in 14 (33.3%) patients, NDO without DSD in 8 (19%), and acontractile detrusor in 20 (47.6%). Pharmacotherapy was advised to 22 (52.4%) patients, whereas clean intermittent catheterization (CIC)\/self-catheterization was advised to 39 (92.9%) patients.<\/jats:p>\n<jats:p>\n<jats:bold>Conclusions<\/jats:bold>\u2003Urinary retention was observed to be the most common urinary complaint in patients with NMOSD followed by NDO with or without sphincter dyssynergia. Urodynamics should be performed in all patients with LUTSs for best management. CIC remains the gold standard for the management of neurogenic bladder dysfunction.<\/jats:p>","DOI":"10.1055\/s-0040-1701557","type":"journal-article","created":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T23:50:12Z","timestamp":1582242612000},"page":"245-249","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Urinary Symptoms and Bladder Dysfunction in Patients with Neuromyelitis Optica Spectrum Disorders: Evaluation with Urodynamics and Management"],"prefix":"10.25259","volume":"11","author":[{"given":"Anupam","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Neurological Rehabilitation, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisseril","family":"Sivaram","sequence":"additional","affiliation":[{"name":"Department of Neurological Rehabilitation, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Department of Neurological Rehabilitation, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meeka","family":"Khanna","sequence":"additional","affiliation":[{"name":"Department of Neurological Rehabilitation, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2020,2,20]]},"reference":[{"key":"10.1055\/s-0040-1701557\/ref-1","first-page":"581","article-title":"Neuromyelitis optica (Devic\u2019s syndrome)","author":"Wingerchuk","year":"2014"},{"issue":"9","key":"10.1055\/s-0040-1701557\/ref-2","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S1474-4422(07)70216-8","article-title":"The spectrum of neuromyelitis optica","volume":"6","author":"Wingerchuk","year":"2007","journal-title":"Lancet Neurol"},{"issue":"10","key":"10.1055\/s-0040-1701557\/ref-3","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1212\/01.wnl.0000216139.44259.74","article-title":"Revised diagnostic criteria for neuromyelitis optica","volume":"66","author":"Wingerchuk","year":"2006","journal-title":"Neurology"},{"issue":"2","key":"10.1055\/s-0040-1701557\/ref-4","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1212\/WNL.0000000000001729","article-title":"International Panel for NMO Diagnosis. International consensus diagnostic criteria for neuromyelitis optica spectrum disorders","volume":"85","author":"Wingerchuk","year":"2015","journal-title":"Neurology"},{"issue":"10","key":"10.1055\/s-0040-1701557\/ref-5","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1007\/s00415-017-8596-7","article-title":"What proportion of AQP4-IgG-negative NMO spectrum disorder patients are MOG-IgG positive? A cross sectional study of 132 patients","volume":"264","author":"Hamid","year":"2017","journal-title":"J Neurol"},{"issue":"3","key":"10.1055\/s-0040-1701557\/ref-6","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/WCO.0000000000000551","article-title":"Mechanisms for lesion localization in neuromyelitis optica spectrum disorders","volume":"31","author":"Bradl","year":"2018","journal-title":"Curr Opin Neurol"},{"issue":"7","key":"10.1055\/s-0040-1701557\/ref-7","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1177\/1352458515572406","article-title":"Demographic and clinical features of neuromyelitis optica: a review","volume":"21","author":"Pandit","year":"2015","journal-title":"Mult Scler"},{"key":"10.1055\/s-0040-1701557\/ref-8","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.clineuro.2016.06.011","article-title":"Longitudinally extensive transverse myelitis: a retrospective analysis of sixty-four patients at tertiary care center of North-West India","volume":"148","author":"Jain","year":"2016","journal-title":"Clin Neurol Neurosurg"},{"issue":"4","key":"10.1055\/s-0040-1701557\/ref-9","doi-asserted-by":"crossref","first-page":"572","DOI":"10.4103\/0972-2327.120474","article-title":"Optimizing the management of neuromyelitis optica and spectrum disorders in resource poor settings: experience from the Mangalore demyelinating disease registry","volume":"16","author":"Pandit","year":"2013","journal-title":"Ann Indian Acad Neurol"},{"issue":"2","key":"10.1055\/s-0040-1701557\/ref-10","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/cei.12271","article-title":"Neuromyelitis optica: clinical features, immunopathogenesis and treatment","volume":"176","author":"Jarius","year":"2014","journal-title":"Clin Exp Immunol"},{"issue":"1","key":"10.1055\/s-0040-1701557\/ref-11","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00415-004-0271-0","article-title":"Italian Devic\u2019s Study Group (IDESG). Clinical characteristics, course and prognosis of relapsing Devic\u2019s Neuromyelitis Optica","volume":"251","author":"Ghezzi","year":"2004","journal-title":"J Neurol"},{"issue":"5","key":"10.1055\/s-0040-1701557\/ref-12","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1212\/01.WNL.0000049912.02954.2C","article-title":"Neuromyelitis optica: clinical predictors of a relapsing course and survival","volume":"60","author":"Wingerchuk","year":"2003","journal-title":"Neurology"},{"issue":"5","key":"10.1055\/s-0040-1701557\/ref-13","doi-asserted-by":"crossref","first-page":"e269","DOI":"10.1212\/NXI.0000000000000269","article-title":"Early indicators of relapses vs pseudorelapses in neuromyelitis optica spectrum disorder","volume":"3","author":"Kessler","year":"2016","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"issue":"1","key":"10.1055\/s-0040-1701557\/ref-14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00415-013-7169-7","article-title":"Neuromyelitis Optica Study Group (NEMOS). 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A cross sectional study of 60 patients with aquaporin-4 antibody positive Neuromyelitis Optica spectrum disorder","volume":"4","author":"Mutch","year":"2015","journal-title":"Mult Scler Relat Disord"},{"issue":"5","key":"10.1055\/s-0040-1701557\/ref-19","first-page":"S13","article-title":"Neurogenic bladder following myelopathies: has it any correlation with neurological and functional recovery?","volume":"5","author":"Menon","year":"2014","journal-title":"J Neurosci Rural Pract"},{"issue":"2","key":"10.1055\/s-0040-1701557\/ref-20","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1136\/jnnp.73.2.154","article-title":"Bladder dysfunction in acute transverse myelitis: magnetic resonance imaging and neurophysiological and urodynamic correlations","volume":"73","author":"Kalita","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"10.1055\/s-0040-1701557\/ref-21","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/cen3.12279","article-title":"Urinary symptoms and neurological disabilities are differentially correlated between multiple sclerosis and neuromyelitis optica","volume":"7","author":"Yamamoto","year":"2016","journal-title":"Clin Exp Neuroimmunol"},{"issue":"3","key":"10.1055\/s-0040-1701557\/ref-22","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s10286-018-0551-x","article-title":"Neurogenic lower urinary tract dysfunction in multiple sclerosis, neuromyelitis optica, and related disorders","volume":"29","author":"Sakakibara","year":"2019","journal-title":"Clin Auton Res"},{"issue":"5","key":"10.1055\/s-0040-1701557\/ref-23","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1002\/nau.23501","article-title":"Value of urodynamic findings in predicting upper urinary tract damage in neuro-urological patients: a systematic review","volume":"37","author":"Musco","year":"2018","journal-title":"Neurourol Urodyn"},{"issue":"1","key":"10.1055\/s-0040-1701557\/ref-24","doi-asserted-by":"crossref","first-page":"42","DOI":"10.4103\/0972-2327.107693","article-title":"Urodynamic profile of patients with neurogenic bladder following non-traumatic myelopathies","volume":"16","author":"Gupta","year":"2013","journal-title":"Ann Indian Acad Neurol"}],"container-title":["Journal of Neurosciences in Rural Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ruralneuropractice.com\/urinary-symptoms-and-bladder-dysfunction-in-patients-with-neuromyelitis-optica-spectrum-disorders-evaluation-with-urodynamics-and-management\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ruralneuropractice.com\/urinary-symptoms-and-bladder-dysfunction-in-patients-with-neuromyelitis-optica-spectrum-disorders-evaluation-with-urodynamics-and-management\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,5]],"date-time":"2023-08-05T04:41:16Z","timestamp":1691210476000},"score":1,"resource":{"primary":{"URL":"https:\/\/ruralneuropractice.com\/urinary-symptoms-and-bladder-dysfunction-in-patients-with-neuromyelitis-optica-spectrum-disorders-evaluation-with-urodynamics-and-management\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,20]]},"references-count":24,"alternative-id":["10.1055\/s-0040-1701557"],"URL":"https:\/\/doi.org\/10.1055\/s-0040-1701557","relation":{},"ISSN":["0976-3147"],"issn-type":[{"value":"0976-3147","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,20]]},"article-number":"245"}}