{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T01:21:42Z","timestamp":1790990502308,"version":"4.1.0"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"S 03","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["5T32DC000022-30"],"award-info":[{"award-number":["5T32DC000022-30"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences of the NIH","doi-asserted-by":"crossref","award":["UL1TR002345"],"award-info":[{"award-number":["UL1TR002345"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg B Skull Base"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Objective\u2003To investigate the diagnostic performance of computed tomography (CT) to determine the origin, skull base involvement, and stage of sinonasal inverted papilloma (IP).<\/jats:p><jats:p>Design\u2003This is a retrospective cohort study.<\/jats:p><jats:p>Setting\u2003This is set at a tertiary care medical center.<\/jats:p><jats:p>Participants\u2003Patients with preoperative CT imaging who underwent extirpative surgery for histologically confirmed sinonasal IP between January 2005 and October 2019.<\/jats:p><jats:p>Main Outcome Measures\u2003The likely sites of tumor origin, skull base involvement, and radiographic tumor stage were determined by two board-certified neuroradiologists after re-reviewing preoperative CT imaging. These radiologic findings were then compared with intraoperative and pathologic findings.<\/jats:p><jats:p>Results\u2003Of 86 patients, 74% (64\/86) had IP lesions with correctly classified sites of origin on CT. CT was not sensitive for diagnosing ethmoid sinus origin (48%, 52%), frontal sinus origin (80%, 40%), and skull base origin (17%, 17%). CT was not sensitive (62%, 57%) but specific (86%, 98%) for identifying any skull base involvement. There was substantial-to-near perfect agreement between radiographic and pathologic Cannady stages (weighted \u03ba\u2009=\u20090.61 for rater 1; weighted \u03ba\u2009=\u20090.81 for rater 2). Interrater agreement was substantial for identifying tumor origin (\u03ba\u2009=\u20090.75) and stage (weighted \u03ba\u2009=\u20090.62) and moderate for identifying skull base involvement (\u03ba\u2009=\u20090.43).<\/jats:p><jats:p>Conclusion\u2003Interrater agreement on CT findings was substantial except on skull base involvement. CT correctly predicted site of tumor origin in up to 74% of subjects. CT was not sensitive for diagnosing skull base involvement but had substantial-to-near perfect agreement with pathologic tumor staging. CT is a useful but albeit limited adjunct for tumor localization and surgical planning for sinonasal IP.<\/jats:p>","DOI":"10.1055\/s-0040-1701677","type":"journal-article","created":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T21:05:39Z","timestamp":1585688739000},"page":"e335-e341","source":"Crossref","is-referenced-by-count":6,"special_numbering":"S","title":["Computed Tomography as a Predictor of Sinonasal Inverted Papilloma Origin, Skull Base Involvement, and Stage"],"prefix":"10.1055","volume":"82","author":[{"given":"Jake J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary L. P.","family":"Orlowski","sequence":"additional","affiliation":[{"name":"Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren T.","family":"Roland","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri, United States"},{"name":"Department of Otolaryngology-Head and Neck Surgery, Emory University School of Medicine, Atlanta, Georgia, United States"},{"name":"Department of Otolaryngology-Head and Neck Surgery, San Francisco School of Medicine, University of California, San Francisco, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami","family":"Eldaya","sequence":"additional","affiliation":[{"name":"Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawina","family":"Jiramongkolchai","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorina","family":"Kallogjeri","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca D.","family":"Chernock","sequence":"additional","affiliation":[{"name":"Department of Pathology, Washington University School of Medicine, St. Louis, Missouri, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristine N.","family":"Klatt-Cromwell","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,2,20]]},"reference":[{"issue":"09","key":"ref1","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1097\/01.mlg.0000230401.88711.e6","article-title":"Radiographic and histologic analysis of the bone underlying inverted papillomas","volume":"116","author":"A G Chiu","year":"2006","journal-title":"Laryngoscope"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1177\/000348947108000205","article-title":"Papillomas of the nasal cavity and paranasal sinuses. 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