{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T13:59:03Z","timestamp":1760623143220},"reference-count":22,"publisher":"Scientific Scholar","license":[{"start":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T00:00:00Z","timestamp":1584403200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ruralneuropractice.com"],"crossmark-restriction":true},"short-container-title":["JNRP"],"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p>\n<jats:bold>Objective<\/jats:bold>\u2003Panic disorder (PD) is associated with changes in platelet and red blood cell (RBC) indices. However, the diagnostic or predictive value of these indices is unknown. This study assessed the diagnostic and discriminating value of platelet and RBC indices in patients with PD.<\/jats:p>\n<jats:p>\n<jats:bold>Materials and Methods<\/jats:bold>\u2003In this cross-sectional study including patients with PD (<jats:italic>n<\/jats:italic> = 98) and healthy controls (<jats:italic>n<\/jats:italic> = 102), we compared the following blood indices: mean platelet volume (MPV), platelet distribution width (PDW), and RBC distribution width (RDW). The receiver operating characteristic (ROC) curve was used to calculate the area under the ROC curve (AUC), sensitivity, specificity, and likelihood ratio for the platelet and RBC indices.<\/jats:p>\n<jats:p>\n<jats:bold>Results<\/jats:bold>\u2003Statistically significant increase in PDW (17.01 \u00b1 0.91 vs. 14.8 \u00b1 2.06; <jats:italic>p<\/jats:italic> &lt; 0.0001) and RDW (16.56 \u00b1 2.32 vs. 15.12 \u00b1 2.43; <jats:italic>p<\/jats:italic> &lt; 0.0001) levels were observed in patients with PD. PDW and mean corpuscular hemoglobin concentration had larger AUC (0.89 and 0.74, respectively) and Youden\u2019s index (0.65 and 0.39, respectively), indicating their higher predictive capacity as well as higher sensitivity in discriminating patients with PD from healthy controls.<\/jats:p>\n<jats:p>\n<jats:bold>Conclusion<\/jats:bold>\u2003PDW can be considered a \u201cgood\u201d diagnostic or predictive marker in patients with PD.<\/jats:p>","DOI":"10.1055\/s-0040-1703422","type":"journal-article","created":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:11:48Z","timestamp":1584490308000},"page":"261-266","update-policy":"http:\/\/dx.doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Platelet and Red Blood Cell Indices in Patients with Panic Disorder: A Receiver Operating Characteristic Analysis"],"prefix":"10.25259","volume":"11","author":[{"given":"Ramdas S.","family":"Ransing","sequence":"first","affiliation":[{"name":"Department of Psychiatry, BKL Walawalkar Rural Medical College, Ratnagiri, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neha","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Mahatma Gandhi Institute of Medical Sciences, Wardha, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Girish","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Mahatma Gandhi Institute of Medical Sciences, Wardha, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilima","family":"Mahapatro","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, BKL Walawalkar Rural Medical College, Ratnagiri, Maharashtra, 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