{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T08:39:36Z","timestamp":1768552776018,"version":"3.49.0"},"reference-count":29,"publisher":"Scientific Scholar","license":[{"start":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T00:00:00Z","timestamp":1584403200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ruralneuropractice.com"],"crossmark-restriction":true},"short-container-title":["JNRP"],"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p>\n<jats:bold>Background<\/jats:bold>\u2003Dexmedetomidine could be a suitable adjuvant in neuroanesthesia due to its analgesic and anesthetic-sparing properties with the added advantage of facilitating intraoperative neuromonitoring. However, its recovery profile is still debated upon, as in neuroanesthesia, a prompt recovery is essential for postoperative neurologic assessment. We designed this study to evaluate the effect of dexmedetomidine on the anesthetic and recovery profile of patients presenting for supratentorial neurosurgeries.<\/jats:p>\n<jats:p>\n<jats:bold>Materials and Methods<\/jats:bold>\u2003Forty adult patients undergoing supratentorial surgeries were recruited in this prospective, randomized, double-blinded study and were divided into two groups: group S and group SD. Both groups received sevoflurane and fentanyl for maintenance, whereas group SD alone received a low dose of dexmedetomidine infusion. Recovery parameters, opioid consumption, Richmond Agitation\u2013Sedation Scale (RASS) and visual analogue scale (VAS) scores, incidence of nausea and vomiting, and intraoperative hemodynamics were analyzed.<\/jats:p>\n<jats:p>\n<jats:bold>Results<\/jats:bold>\u2003 There were no statistically significant differences between the groups S and SD in case of recovery parameters\u2014time taken (in minutes, presented as median with interquartile range [IQR]) for (1) eye-opening to command: 9.5 (8\u201318) versus 22.5 (5\u201347.5) (<jats:italic>p<\/jats:italic> = 0.414); 2) following verbal command: 10.5 (8.25\u201329.5) versus 25 (10\u201328.75) (<jats:italic>p<\/jats:italic> = 0.512); (3) extubation: 11 (9.25\u201322) versus 25 (10\u201330) (<jats:italic>p<\/jats:italic> = 0.277); and (4) getting oriented to place, time, and date: 23 (20\u201352.75) versus 27.5 (25\u201336.5) (<jats:italic>p<\/jats:italic> = 0.121). Fentanyl consumption was significantly less in group SD (451 \u00b1 39.3) versus group S (524.3 \u00b1 144.1) (<jats:italic>p<\/jats:italic> = 0.034). The median RASS score with IQR and the median VAS scores with IQR were comparable between the groups at all time points. Of the 20 patients in group S, 5 had complaints of nausea and vomiting compared with none in the group SD, although it was not statistically significant. The hemodynamic parameters did not show a significant difference between the groups except for a surge in mean arterial pressure at 30 minutes in group S.<\/jats:p>\n<jats:p>\n<jats:bold>Conclusion<\/jats:bold>\u2003Low-dose dexmedetomidine as an adjuvant to sevoflurane- and fentanyl-based anesthesia could provide stable hemodynamics and lesser anesthetics and opioid consumption, without adversely affecting the recovery profile in patients undergoing supratentorial neurosurgical procedures.<\/jats:p>","DOI":"10.1055\/s-0040-1703968","type":"journal-article","created":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:11:48Z","timestamp":1584490308000},"page":"267-273","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effect of Low-Dose Dexmedetomidine on the Anesthetic and Recovery Profile of Sevoflurane-Based Anesthesia in Patients Presenting for Supratentorial Neurosurgeries: A Randomized Double-Blind Placebo-Controlled Trial"],"prefix":"10.25259","volume":"11","author":[{"given":"Unnikrishnan","family":"Prathapadas","sequence":"first","affiliation":[{"name":"Division of Neuroanaesthesia, Department of Anaesthesiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay Prasad","family":"Hrishi","sequence":"additional","affiliation":[{"name":"Division of Neuroanaesthesia, Department of Anaesthesiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arulvelan","family":"Appavoo","sequence":"additional","affiliation":[{"name":"Department of Neuro Anaesthesiology, Institute of Neuro Sciences, SIMS Hospital, Chennai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smita","family":"Vimala","sequence":"additional","affiliation":[{"name":"Division of Neuroanaesthesia, Department of Anaesthesiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manikandan","family":"Sethuraman","sequence":"additional","affiliation":[{"name":"Division of Neuroanaesthesia, Department of Anaesthesiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2020,3,17]]},"reference":[{"issue":"3","key":"10.1055\/s-0040-1703968\/ref-1","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1093\/bja\/83.3.372","article-title":"Effects of dexmedetomidine on isoflurane requirements in healthy volunteers. 1: pharmacodynamic and pharmacokinetic interactions","volume":"83","author":"Khan","year":"1999","journal-title":"Br J 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