{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T04:17:21Z","timestamp":1768450641347,"version":"3.49.0"},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"S 01","funder":[{"name":"Ferring Pharmaceuticals","award":["IIT-2016-100752"],"award-info":[{"award-number":["IIT-2016-100752"]}]},{"name":"National Institutes of Health, National Institute of General Medical Sciences","award":["1 U54GM104938"],"award-info":[{"award-number":["1 U54GM104938"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003The aim of study is to compare, in a pilot study, combined dinoprostone vaginal insert and Foley catheter (DVI\u2009+\u2009Foley) with Foley alone (Foley) for cervical ripening and labor induction at term.<\/jats:p><jats:p>\n          Study Design\u2003In this open-label pilot randomized controlled trial, women not in labor, with intact membranes, no prior uterine incision, an unfavorable cervix, gestational age \u226537 weeks, and a live, nonanomalous singleton fetus in cephalic presentation were randomly assigned, stratified by parity, to DVI\u2009+\u2009Foley or Foley. Oxytocin was used in both groups after cervical ripening. Primary outcome was time to vaginal delivery.<\/jats:p><jats:p>\n          Results\u2003From April 2017 to January 2018, 100 women were randomized. Median (25\u201375th percentile) time to vaginal delivery for nulliparous women was 21.2 (16.6\u201338.0) hours with DVI\u2009+\u2009Foley (n\u2009=\u200926) compared with 31.3 (23.3\u201346.9) hours with Foley (n\u2009=\u200924) (Wilcoxon p\u2009=\u20090.05). Median time to vaginal delivery for parous women was 17.1 (13.6\u201321.9) hours with DVI\u2009+\u2009Foley (n\u2009=\u200925) compared with 14.8 (12.7\u201319.5) hours with Foley (n\u2009=\u200925) (Wilcoxon p\u2009=\u20090.21). Results were also analyzed to consider the competing risk of cesarean using cumulative incidence functions.<\/jats:p><jats:p>\n          Conclusion\u2003Compared with Foley alone, combined use of the dinoprostone vaginal insert and Foley for cervical ripening may shorten time to vaginal delivery for nulliparous but not parous women.<\/jats:p>","DOI":"10.1055\/s-0040-1705113","type":"journal-article","created":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T00:01:20Z","timestamp":1583193680000},"page":"e57-e63","source":"Crossref","is-referenced-by-count":8,"special_numbering":"S","title":["Controlled Release Dinoprostone Insert and Foley Compared to Foley Alone: A Randomized Pilot Trial"],"prefix":"10.1055","volume":"38","author":[{"given":"Rodney K.","family":"Edwards","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle L.","family":"Norris","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell D.","family":"West","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, Louisiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Zornes","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine A.","family":"Loeffler","sequence":"additional","affiliation":[{"name":"School of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer D.","family":"Peck","sequence":"additional","affiliation":[{"name":"School of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,3,2]]},"reference":[{"issue":"01","key":"ref1","first-page":"1","article-title":"Births: final data for 2010","volume":"61","author":"J A Martin","year":"2012","journal-title":"Natl Vital Stat Rep"},{"issue":"01","key":"ref2","first-page":"1","article-title":"Births: final data for 1999","volume":"49","author":"S J Ventura","year":"2001","journal-title":"Natl Vital Stat Rep"},{"issue":"06","key":"ref3","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1056\/NEJMoa1800566","article-title":"Labor induction versus expectant management in low-risk nulliparous women","volume":"379","author":"W A Grobman","year":"2018","journal-title":"N Engl J Med"},{"issue":"04","key":"ref4","first-page":"CD003246","article-title":"Intravenous oxytocin alone for cervical ripening and induction of labour","author":"Z Alfirevic","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"issue":"10","key":"ref5","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.3109\/14767058.2012.668584","article-title":"Pre-induction of labour: comparing dinoprostone vaginal insert to repeated prostaglandin administration: a systematic review and meta-analysis","volume":"25","author":"F Facchinetti","year":"2012","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"06","key":"ref6","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1097\/AOG.0000000000000238","article-title":"Foley catheter compared with the controlled-release dinoprostone insert: a randomized controlled trial","volume":"123","author":"R K Edwards","year":"2014","journal-title":"Obstet Gynecol"},{"issue":"06","key":"ref7","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/ajo.12489","article-title":"Combined Foley's catheter with vaginal misoprostol for pre-induction cervical ripening: a randomised controlled trial","volume":"56","author":"O P Aduloju","year":"2016","journal-title":"Aust N Z J Obstet Gynaecol"},{"issue":"06","key":"ref8","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1111\/jog.12396","article-title":"Concurrent use of Foley catheter and misoprostol for induction of labor: a randomized clinical trial of efficacy and safety","volume":"40","author":"S Lanka","year":"2014","journal-title":"J Obstet Gynaecol Res"},{"issue":"03","key":"ref9","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1097\/01.AOG.0000444441.04111.1d","article-title":"Obstetric care consensus no. 1: safe prevention of the primary cesarean delivery","volume":"123","year":"2014","journal-title":"Obstet 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Harris","year":"2009","journal-title":"J Biomed Inform"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/AOG.0b013e31827e5dca","article-title":"Combination of Foley bulb and vaginal misoprostol compared with vaginal misoprostol alone for cervical ripening and labor induction: a randomized controlled trial","volume":"121","author":"J F Carbone","year":"2013","journal-title":"Obstet Gynecol"},{"issue":"03","key":"ref14","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ijgo.2015.01.005","article-title":"Meta-analysis of Foley catheter plus misoprostol versus misoprostol alone for cervical ripening","volume":"129","author":"W Chen","year":"2015","journal-title":"Int J Gynaecol Obstet"},{"issue":"01","key":"ref15","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/AOG.0000000000002403","article-title":"Misoprostol with Foley bulb compared with misoprostol alone for cervical ripening: a randomized controlled 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Bauer","year":"2018","journal-title":"Am J Obstet Gynecol"},{"issue":"06","key":"ref19","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1097\/AOG.0000000000002032","article-title":"Intracervical Foley catheter with and without oxytocin for labor induction: a randomized controlled trial","volume":"129","author":"C N Schoen","year":"2017","journal-title":"Obstet Gynecol"}],"container-title":["American Journal of 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