{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:48:42Z","timestamp":1790362122092,"version":"4.1.0"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"S 01","funder":[{"name":"the University of Utah Population Health Research Foundation"},{"name":"National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health","award":["UL1TR002538"],"award-info":[{"award-number":["UL1TR002538"]}]},{"name":"National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health","award":["5UL1TR001067-05"],"award-info":[{"award-number":["5UL1TR001067-05"]}]},{"name":"National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health","award":["8UL1TR000105"],"award-info":[{"award-number":["8UL1TR000105"]}]},{"name":"National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health","award":["UL1RR025764"],"award-info":[{"award-number":["UL1RR025764"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003This study aimed to establish neonatal serum triglyceride (TG) level reference ranges during lipid infusion and correlate peak TG with neonatal outcomes.<\/jats:p><jats:p>\n          Study Design\u2003This is a retrospective review of 356 neonates with 696 TG measures obtained in four neonatal intensive care units between 2015 and 2017. TG was evaluated collectively to establish a reference range and a threshold limit. To analyze the effects of a higher TG threshold, neonates were categorized by their peak TG: &lt;180 (TG&lt;180), 180 to 400 (TG180\u2013400), and\u2009&gt;\u2009400\u2009mg\/dL (TG&gt;400). Univariable and multivariable regression models were constructed to compare peak TG to patient characteristic and clinical outcomes.<\/jats:p><jats:p>\n          Results\u2003The frequency of TG\u2009&gt;\u2009400\u2009mg\/dL was 5% and found only in neonates weighing\u2009&lt;\u20091.5\u2009kg. Neonates in the TG180\u2013400 (n\u2009=\u200991) group were significantly lower in birth weight and gestational age, had lower 5-minute APGAR scores, and had increased ventilatory requirement when compared with neonates in the TG&lt;180 (n\u2009=\u2009240) group (all p\u2009&lt;\u20090.001). The TG180\u2013400 group had increased risk of severe intraventricular hemorrhage (p\u2009=\u20090.02) and bronchopulmonary dysplasia (p\u2009=\u20090.03). Elevated TG was associated with mortality (odds ratio [OR]: 14.4, p\u2009&lt;\u20090.001) in univariable analysis, but the relationship weakened (OR: 4.4, p\u2009=\u20090.05) after adjusting for comorbidities in multivariable logistic regression.<\/jats:p><jats:p>\n          Conclusion\u2003It is unclear if the adverse outcomes seen in neonates with higher peak TG were due to elevated TG alone, or whether illness severity predicted the increased TG. More prospective studies are needed to further delineate the relationships.<\/jats:p>","DOI":"10.1055\/s-0040-1705174","type":"journal-article","created":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T00:01:20Z","timestamp":1583193680000},"page":"e92-e101","source":"Crossref","is-referenced-by-count":6,"special_numbering":"S","title":["An Evaluation to Establish the Acceptable Serum Triglyceride Levels in Neonates Receiving Intravenous Fat Emulsion Infusion in a Multicenter Retrospective Study"],"prefix":"10.1055","volume":"38","author":[{"given":"Belinda","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anh","family":"Lian","sequence":"additional","affiliation":[{"name":"Pharmacy Services, Intermountain Healthcare, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vickie","family":"Baer","sequence":"additional","affiliation":[{"name":"Women and Newborn Research, Intermountain Healthcare, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandy","family":"Robinson","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhining","family":"Ou","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Internal Medicine, University of Utah, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela P.","family":"Presson","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Internal Medicine, University of Utah, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6085-6976","authenticated-orcid":false,"given":"Erin K.","family":"Zinkhan","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,3,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1016\/j.jpeds.2012.11.052","article-title":"Lipid needs of preterm infants: updated recommendations","volume":"162","author":"A Lapillonne","year":"2013","journal-title":"J Pediatr"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.siny.2016.08.009","article-title":"Fatty acid requirements for the preterm infant","volume":"22","author":"D T Robinson","year":"2017","journal-title":"Semin Fetal Neonatal 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Nutr"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1016\/j.clnu.2018.06.946","article-title":"ESPGHAN\/ESPEN\/ESPR\/CSPEN guidelines on pediatric parenteral nutrition: lipids","volume":"37","author":"A Lapillonne","year":"2018","journal-title":"Clin Nutr"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1471-2431-13-59","article-title":"A systematic review and meta-analysis to revise the Fenton growth chart for preterm infants","volume":"13","author":"T R Fenton","year":"2013","journal-title":"BMC Pediatr"},{"issue":"06","key":"ref9","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1093\/aje\/kwk052","article-title":"Relaxing the rule of ten events per variable in logistic and Cox regression","volume":"165","author":"E Vittinghoff","year":"2007","journal-title":"Am J Epidemiol"},{"key":"ref11","first-page":"19","volume-title":"The interpretation of biochemical data","author":"W J Marshall","year":"2008"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1651-2227.1990.tb11519.x","article-title":"Lipid levels in very low birthweight preterm infants","volume":"79","author":"T Decsi","year":"1990","journal-title":"Acta Paediatr Scand"},{"issue":"03","key":"ref13","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0022-3476(84)81111-7","article-title":"Triglycerides, free fatty acids, free fatty acids\/albumin molar ratio, and cholesterol levels in serum of neonates receiving long-term lipid infusions: controlled trial of continuous and intermittent regimens","volume":"104","author":"L C Kao","year":"1984","journal-title":"J Pediatr"},{"issue":"01","key":"ref14","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1177\/011542659701200126","article-title":"Serum triglycerides of breast milk-fed very-low-birth-weight infants","volume":"12","author":"T R Fenton","year":"1997","journal-title":"Nutr Clin Pract"},{"issue":"03","key":"ref15","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S0022-3476(87)80481-X","article-title":"Late hypertriglyceridemia in very low birth weight infants fed human milk exclusively","volume":"111","author":"F R Greer","year":"1987","journal-title":"J Pediatr"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jpeds.2016.12.026","article-title":"Effects of soybean lipid infusion on unbound free fatty acids and unbound bilirubin in preterm infants","volume":"184","author":"T Hegyi","year":"2017","journal-title":"J Pediatr"},{"issue":"02","key":"ref17","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1055\/s-2007-999459","article-title":"Tolerance of fat emulsions in very low birthweight neonates: effect of birthweight on plasma lipid concentrations","volume":"7","author":"Y W Brans","year":"1990","journal-title":"Am J Perinatol"},{"issue":"05","key":"ref18","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1007\/s12272-014-0405-6","article-title":"Analysis of risk factors for lipid intolerance of intravenous fat emulsion in very low birth weight infants","volume":"38","author":"Y J Choi","year":"2015","journal-title":"Arch Pharm Res"},{"issue":"01","key":"ref19","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1186\/s12887-018-1325-2","article-title":"Hypertriglyceridaemia in extremely preterm infants receiving parenteral lipid emulsions","volume":"18","author":"R Sinclair","year":"2018","journal-title":"BMC Pediatr"},{"issue":"05","key":"ref20","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1056\/NEJM199008023230504","article-title":"Association of intravenous lipid emulsion and coagulase-negative staphylococcal bacteremia in neonatal intensive care units","volume":"323","author":"J Freeman","year":"1990","journal-title":"N Engl J Med"},{"issue":"02","key":"ref21","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3945\/ajcn.112.040717","article-title":"Parenteral lipid administration to very-low-birth-weight infants--early introduction of lipids and use of new lipid emulsions: a systematic review and meta-analysis","volume":"96","author":"H Vlaardingerbroek","year":"2012","journal-title":"Am J Clin Nutr"},{"issue":"04","key":"ref22","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1177\/0148607111420061","article-title":"Bloodstream infections in patients receiving manufactured parenteral nutrition with vs without lipids: is the use of lipids really deleterious?","volume":"36","author":"A Pontes-Arruda","year":"2012","journal-title":"JPEN J Parenter Enteral Nutr"},{"issue":"05","key":"ref23","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s00431-018-3112-3","article-title":"Inpatient outcomes of preterm infants receiving \u03c9-3 enriched lipid emulsion (SMOFlipid): an observational study","volume":"177","author":"N Choudhary","year":"2018","journal-title":"Eur J Pediatr"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1136\/adc.66.1_Spec_No.26","article-title":"Pulmonary intravascular lipid in neonatal necropsy specimens","volume":"66","author":"J W Puntis","year":"1991","journal-title":"Arch Dis Child"},{"issue":"01","key":"ref26","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1542\/peds.78.1.79","article-title":"Fat emulsion tolerance in very low birth weight neonates: effect on diffusion of oxygen in the lungs and on blood pH","volume":"78","author":"Y W Brans","year":"1986","journal-title":"Pediatrics"},{"issue":"05","key":"ref27","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.jpeds.2011.04.039","article-title":"Decreased postnatal docosahexaenoic and arachidonic acid blood levels in premature infants are associated with neonatal morbidities","volume":"159","author":"C R Martin","year":"2011","journal-title":"J Pediatr"},{"issue":"02","key":"ref28","doi-asserted-by":"crossref","first-page":"F95","DOI":"10.1136\/fn.74.2.F95","article-title":"Pulmonary vascular resistance during lipid infusion in neonates","volume":"74","author":"W Prasertsom","year":"1996","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"03","key":"ref29","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00383-004-1319-z","article-title":"Effects of Intralipid infusion on hemorheology and peripheral resistance in neonates and children","volume":"21","author":"U Kessler","year":"2005","journal-title":"Pediatr Surg Int"},{"key":"ref30","first-page":"CD000509","article-title":"Inhaled nitric oxide for respiratory failure in preterm infants","volume":"1","author":"K J Barrington","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"issue":"01","key":"ref31","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1177\/0884217504272805","article-title":"Update on nutrition for preterm and full-term infants","volume":"34","author":"K Gregory","year":"2005","journal-title":"J Obstet Gynecol Neonatal Nurs"},{"issue":"05","key":"ref32","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1067\/mpd.2003.149","article-title":"Catch-up growth of head circumference of very low birth weight, small for gestational age preterm infants and mental development to adulthood","volume":"142","author":"I Brandt","year":"2003","journal-title":"J Pediatr"},{"issue":"05","key":"ref33","doi-asserted-by":"crossref","first-page":"F337","DOI":"10.1136\/adc.2007.124230","article-title":"Improving head growth in very preterm infants--a randomised controlled trial I: neonatal outcomes","volume":"93","author":"M J Tan","year":"2008","journal-title":"Arch Dis Child Fetal Neonatal 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