{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:21:31Z","timestamp":1792606891501,"version":"4.5.0"},"reference-count":73,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Thromb Hemost"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Extracorporeal membrane oxygenation (ECMO) is a form of life support used to treat neonates, children, and adults with cardiorespiratory failure refractory to conventional therapy. This therapy requires the use of anticoagulation to prevent clotting in the extracorporeal circuit, but anticoagulation also increases the risk of bleeding on ECMO. Both bleeding and thrombosis remain significant complications on ECMO and balancing these risks is challenging. Acquired platelet dysfunction is common during ECMO and quantitative and qualitative platelet dysfunction contributes to bleeding risk. Optimal platelet count, function, and transfusion thresholds are not well established during pediatric ECMO. In this review, we provide an overview of hemostatic alterations during ECMO, changes in platelet count and function, platelet monitoring techniques, bleeding risk, and future needs to best optimize patient management and care.<\/jats:p>","DOI":"10.1055\/s-0040-1708542","type":"journal-article","created":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T23:33:47Z","timestamp":1585697627000},"page":"357-365","source":"Crossref","is-referenced-by-count":21,"title":["Platelet Count and Function during Pediatric Extracorporeal Membrane Oxygenation"],"prefix":"10.1055","volume":"46","author":[{"given":"Katherine","family":"Cashen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Critical Care Medicine, Children's Hospital of Michigan, Wayne State University, Detroit, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Meert","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Critical Care Medicine, Children's Hospital of Michigan, Wayne State University, Detroit, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi J.","family":"Dalton","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Critical Care Medicine, INOVA Heart and Vascular Institute, Inova Fairfax Medical Institute, Falls Church, Virginia"},{"name":"George Washington University, Washington, Dist. of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,3,31]]},"reference":[{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1097\/MAT.0000000000000603","article-title":"Pediatric extracorporeal life support organization registry international report 2016","volume":"63","author":"R P Barbaro","year":"2017","journal-title":"ASAIO J"},{"issue":"06","key":"ref3","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1164\/rccm.201609-1945OC","article-title":"Factors associated with bleeding and thrombosis in children receiving extracorporeal membrane oxygenation","volume":"196","author":"H J Dalton","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/PCC.0000000000000317","article-title":"Association of bleeding and thrombosis with outcome in extracorporeal life support","volume":"16","author":"H J Dalton","year":"2015","journal-title":"Pediatr Crit Care Med"},{"issue":"08","key":"ref5","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1182\/blood.V80.8.1998.1998","article-title":"Maturation of the hemostatic system during childhood","volume":"80","author":"M Andrew","year":"1992","journal-title":"Blood"},{"issue":"S 01","key":"ref6","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/ijlh.12531","article-title":"Developmental hemostasis: laboratory and clinical implications","volume":"38","author":"P Toulon","year":"2016","journal-title":"Int J Lab Hematol"},{"issue":"02","key":"ref7","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1160\/TH05-01-0047","article-title":"Developmental haemostasis. 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