{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T09:54:23Z","timestamp":1774518863936,"version":"3.50.1"},"reference-count":20,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003This study aimed to evaluate if maternal serum hormones along the maternal\u2013fetal hypothalamic\u2013pituitary\u2013adrenal (HPA) axis, when drawn prior to labor induction, differed between women who delivered vaginally and those who underwent cesarean.<\/jats:p><jats:p>\n          Study Design\u2003This was a prospective observational study at a single perinatal center performed from August 2017 to May 2018. Nulliparous women with uncomplicated singleton pregnancies \u226539 weeks had maternal serum collected prior to induction. Corticotrophin-releasing hormone (CRH) was measured by ELISA; dehydroepiandrosterone sulfate (DHEA-S), cortisol, estriol (E3) estradiol (E2), and progesterone (P4) were measured by chemiluminescent reaction. Mean analyte concentrations as well as three ratios (E2\/P4, E3\/P4, and E2\/E3) were compared between women who had a vaginal versus cesarean delivery. Logistic regression was used to model the relationship between CRH and the odds of vaginal birth. We estimated that a sample size of 66 would have 90% power to detect a 25% difference in mean CRH levels assuming a vaginal:cesarean ratio of 2:1 with a baseline CRH concentration of 140 (standard deviation\u2009=\u200936) pg\/mL.<\/jats:p><jats:p>\n          Results\u2003Of the 88 women who had their serum analyzed, 27 (31%) underwent cesarean. Mean maternal serum CRH levels were similar between the vaginal delivery and cesarean groups (122.6\u2009\u00b1\u200995.2 vs. 112.3\u2009\u00b1\u2009142.4, p\u2009=\u20090.73). Similarly, there were no significant differences in any other maternal serum analytes or ratios. Logistic regression showed a nonsignificant odds ratio for successful vaginal birth (p\u2009=\u20090.69) even when evaluating only the 16 women who had a cesarean for an arrest disorder (p\u2009=\u20090.08).<\/jats:p><jats:p>\n          Conclusion\u2003In low-risk nulliparous women undergoing full-term labor induction, there were no differences noted in a broad array of other maternal-fetal HPA-axis hormones between women who had a vaginal or cesarean delivery.<\/jats:p>","DOI":"10.1055\/s-0040-1708801","type":"journal-article","created":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T01:47:56Z","timestamp":1585187276000},"page":"1195-1200","source":"Crossref","is-referenced-by-count":2,"title":["Association between Maternal Serum Hormones along the Maternal\u2013Fetal Hypothalamic\u2013Pituitary\u2013Adrenal Axis and Successful Vaginal Delivery Measured Prior to Labor Induction"],"prefix":"10.1055","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2107-4183","authenticated-orcid":false,"given":"Chase R.","family":"Cawyer","sequence":"additional","affiliation":[{"name":"Center for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Lobashevksy","sequence":"additional","affiliation":[{"name":"Center for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenda","family":"Corley-Topham","sequence":"additional","affiliation":[{"name":"Center for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Anderson","sequence":"additional","affiliation":[{"name":"UCHealth Maternal Fetal Medicine Clinic, Memorial Hospital Central, Colorado Springs, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Owen","sequence":"additional","affiliation":[{"name":"Center for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akila","family":"Subramaniam","sequence":"additional","affiliation":[{"name":"Center for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,3,25]]},"reference":[{"issue":"01","key":"ref1","first-page":"1","article-title":"Births: final data for 2015. national vital statistics reports: from the centers for disease control and prevention, national center for health statistics","volume":"66","author":"J A Martin","year":"2017","journal-title":"National Vital Statistics 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