{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T10:16:00Z","timestamp":1781950560977,"version":"3.54.5"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"S 01","funder":[{"DOI":"10.13039\/100000912","name":"March of Dimes Foundation","doi-asserted-by":"crossref","award":["6-FY16-160"],"award-info":[{"award-number":["6-FY16-160"]}],"id":[{"id":"10.13039\/100000912","id-type":"DOI","asserted-by":"crossref"}]},{"name":"U.S. Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse","award":["R01DA042948"],"award-info":[{"award-number":["R01DA042948"]}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"crossref","award":["UL1TR001070"],"award-info":[{"award-number":["UL1TR001070"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:p>\n            Objective\u2003The aim of this study is to estimate the association between marijuana use during pregnancy and total, spontaneous and indicated preterm birth.<\/jats:p><jats:p>\n            Study Design\u2003Prospective cohort study of women receiving antenatal care at The Ohio State University from 2010 to 2015. Marijuana use was assessed by questionnaire, record abstraction, and urine toxicology. Women were followed through the end of pregnancy. Relative risks were assessed with Poisson regression and time to delivery with proportional hazard models.<\/jats:p><jats:p>\n            Results\u2003Of 363 eligible women, 119 (33%) used marijuana in pregnancy by at least one measure. In this high-risk cohort, preterm birth occurred to 36.0% of users and 34.6% of nonusers (p\u2009=\u20090.81). The unadjusted relative risk of all preterm birth was 1.06 (95% confidence interval [CI]: 0.76\u20131.47); the adjusted relative risk was similar 1.04 (95% CI: 0.72\u20131.50). Spontaneous preterm birth was nonsignificantly elevated among users before 1.32 (95% CI: 0.89\u20131.96), and after 1.21 (95% CI: 0.76\u20131.94) adjustment. Indicated preterm birth was nonsignificantly reduced before 0.52 (95% CI: 0.22\u20131.23) and after 0.75 (95% CI: 0.29\u20132.15) adjustment. The unadjusted hazard ratio (HR) for time to preterm birth was 1.26 (95% CI: 0.84\u20132.00); the adjusted HR was 1.32 (95% CI: 0.80\u20132.07). Both unadjusted 1.77 (95% CI: 1.06\u20132.93) and adjusted 2.16 (95% CI: 1.16\u20134.02) HRs for spontaneous preterm birth were significantly elevated, primarily due to an increased risk of spontaneous birth &lt;28 weeks among users. The unadjusted and adjusted HRs for time to indicated preterm birth were 0.69 (95% CI: 0.33\u20131.43) and 0.58 (95% CI: 0.23\u20131.46).<\/jats:p><jats:p>\n            Conclusion\u2003Marijuana use was not associated with total preterm birth in this cohort, suggesting that among women already at high risk of preterm birth, marijuana does not increase risk further. However, there was a suggestion that pregnant women who use marijuana may deliver earlier, particularly from spontaneous preterm birth, than women who do not use marijuana.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0040-1708802","type":"journal-article","created":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T13:32:40Z","timestamp":1585834360000},"page":"e146-e154","source":"Crossref","is-referenced-by-count":20,"special_numbering":"S","title":["Marijuana Use during Pregnancy and Preterm Birth: A Prospective Cohort Study"],"prefix":"10.1055","volume":"38","author":[{"given":"Mark A.","family":"Klebanoff","sequence":"additional","affiliation":[{"name":"Center for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio"},{"name":"Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana G.","family":"Wilkins","sequence":"additional","affiliation":[{"name":"Center for Human Toxicology, Department of Pharmacology and Toxicology, The University of Utah, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"Keim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio"},{"name":"Center for Biobehavioral Health, The Abigail Wexner Research Institute, Nationwide Children\u2019s Hospital, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,4,1]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/AOG.0000000000002429","article-title":"Committee opinion no. 722: marijuana use during pregnancy and lactation","volume":"131","author":"A Braillon","year":"2018","journal-title":"Obstet 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