{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T10:39:14Z","timestamp":1678099154184},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropediatrics"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Objective\u2003Duchenne muscular dystrophy (DMD) is a devastating X-linked muscular disorder. The number of studies investigating new therapeutic approaches is substantially increasing. This study aims to investigate the impact and diagnostic value of exercise-induced fatigue in DMD, which has been proposed as a suitable outcome parameter in other conditions like spinal muscular atrophy.<\/jats:p><jats:p>Patients and Methods\u2003A cohort of 55 DMD patients (49 of them treated with steroids and 9 with ataluren) underwent a total of 241 6MWT (mean 4.4 tests\/patient) which were retrospectively analyzed. Exercise-induced fatigue was assessed by the ratio between the distance achieved in the sixth minute and the distance in the second minute of the 6MWT. In previous studies a quotient above 1 was defined as a sign of fatigue.<\/jats:p><jats:p>Results\u2003The average fatigue quotient in the whole cohort of patients was 1.0. In a further analysis no impact of age, steroid therapy, ataluren therapy, overall disability, and distance in the 6-minute walk test (6MWT) on fatigue in DMD patients could be shown.<\/jats:p><jats:p>Conclusion\u2003Our data show that fatigue does not play a relevant role in DMD. Analysis of fatigue is not a useful outcome parameter in DMD studies. For this reason we suggest the 2MWT, which is better accepted by the patients, as an alternative to the commonly 6MWT.<\/jats:p>","DOI":"10.1055\/s-0040-1708859","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T22:44:17Z","timestamp":1588718657000},"page":"342-348","source":"Crossref","is-referenced-by-count":1,"title":["Is Exercise-Induced Fatigue a Problem in Children with Duchenne Muscular Dystrophy?"],"prefix":"10.1055","volume":"51","author":[{"given":"Astrid","family":"Blaschek","sequence":"first","affiliation":[{"name":"Department of Pediatric Neurology and Developmental Medicine, Dr. v. Hauner Children's Hospital, Ludwig-Maximilians University, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Department of Pediatric Neurology and Developmental Medicine, Dr. v. Hauner Children's Hospital, Ludwig-Maximilians University, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"Ille","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology and Developmental Medicine, Dr. v. Hauner Children's Hospital, Ludwig-Maximilians University, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Idriess","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology and Developmental Medicine, Dr. v. Hauner Children's Hospital, Ludwig-Maximilians University, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Therese","family":"Well","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology and Developmental Medicine, Dr. v. Hauner Children's Hospital, Ludwig-Maximilians University, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Warken","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology and Developmental Medicine, Dr. v. Hauner Children's Hospital, Ludwig-Maximilians University, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology and Developmental Medicine, Dr. v. Hauner Children's Hospital, Ludwig-Maximilians University, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"Hannibal","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology and Developmental Medicine, Dr. v. Hauner Children's Hospital, Ludwig-Maximilians University, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moritz","family":"Tacke","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology and Developmental Medicine, Dr. v. Hauner Children's Hospital, Ludwig-Maximilians University, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"M\u00fcller-Felber","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology and Developmental Medicine, Dr. v. 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