{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T22:37:11Z","timestamp":1720737431936},"reference-count":9,"publisher":"Georg Thieme Verlag KG","issue":"S 03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg B Skull Base"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003This study aimed to evaluate surgical outcomes after transzygomatic middle cranial fossa (MCF) (TZ-MCF) approach for tumor control in patients with large skull base lesions involving the MCF and adjacent sites.<\/jats:p><jats:p>\n          Setting\u2003This study was done at the tertiary skull base center.<\/jats:p><jats:p>\n          Design\u2003This is a retrospective case series.<\/jats:p><jats:p>\n          Main Outcome Measures\u2003The main outcome measures were tumor control (recurrence), new-onset cranial neuropathies, facial nerve and audiometric outcomes, cerebrospinal fluid (CSF) leak, and wound complications.<\/jats:p><jats:p>\n          Results\u2003Sixteen patients were identified with a median age of 45 years (range: 20\u201372). The mean maximum tumor dimension was 5.49\u2009cm (standard deviation [SD]: 1.2, range: 3.1\u20137.3) and the mean tumor volume was 28.5\u2009cm3 (SD: 18.8, range: 2.9\u201363.8). Ten (62.5%) tumors were left sided. The most common pathology encountered was meningioma (n\u2009=\u20097) followed by chondrosarcoma (n\u2009=\u20094). Mean follow-up was 36.3 (SD: 26.9) months. Gross total resection or near total resection was achieved in nine (56.2%) and planned subtotal resection was used in seven (43.7%). Postoperative additional new cranial nerve (CN) deficits included CN V (n\u2009=\u20091), CN III (n\u2009=\u20092), CN VI (n\u2009=\u20091), and CN X (n\u2009=\u20091). Major neurological morbidity (hemiplegia) was encountered in two patients with resolution. There were no cases of CSF leak, meningitis, hemorrhage, seizures, aphasia, or death. There was no recurrence or regrowth of residual tumor. Facial nerve function was preserved in all but one patient (House\u2013Brackmann grade 2).<\/jats:p><jats:p>\n          Conclusion\u2003Various skull base tumors involving MCF with extension to adjacent sites can be successfully resected using the TZ-MCF approach in a multidisciplinary fashion. This approach yields optimal exposure and permits excellent tumor control with acceptable CN and neurological morbidity.<\/jats:p>","DOI":"10.1055\/s-0040-1708881","type":"journal-article","created":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T21:11:24Z","timestamp":1585689084000},"page":"e205-e210","source":"Crossref","is-referenced-by-count":0,"special_numbering":"S","title":["Outcomes of Transzygomatic Middle Cranial Fossa Approach for Skull Base Tumors\u2014A Single Institutional Experience"],"prefix":"10.1055","volume":"82","author":[{"given":"Nauman F.","family":"Manzoor","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, The Otology Group of Vanderbilt, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Morone","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick D.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silky","family":"Chotai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Yawn","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, The Otology Group of Vanderbilt, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lola B.","family":"Chambless","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reid C.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Rivas","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, The Otology Group of Vanderbilt, Vanderbilt University Medical Center, Nashville, Tennessee, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,3,28]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/MOO.0000000000000471","article-title":"Comprehensive review of the extended middle cranial fossa approach","volume":"26","author":"N Lipschitz","year":"2018","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1097\/MAO.0000000000001356","article-title":"Treatment of lateral skull base and posterior cranial fossa lesions utilizing the extended middle cranial fossa approach","volume":"38","author":"J P Roche","year":"2017","journal-title":"Otol Neurotol"},{"issue":"05","key":"ref3","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1097\/00129492-200409000-00019","article-title":"Extended middle fossa approach to the petroclival junction and anterior cerebellopontine angle","volume":"25","author":"C Danner","year":"2004","journal-title":"Otol Neurotol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/BF01406489","article-title":"Middle fossa transpetrosal-transtentorial approaches for petroclival meningiomas. 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