{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T03:48:31Z","timestamp":1780717711815,"version":"3.54.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Plastic Surgery"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The implementation of radiotherapy in the multimodal treatment of advanced head and neck cancer has greatly improved survival rates. In some patients, however, this benefit comes at the potential expense of the tissue surrounding the primary site of malignancy. Osteoradionecrosis (ORN) of the facial bones, in particular the maxilla, is a debilitating complication of radiation therapy. Exposure to ionizing radiation results in devitalization of underlying bone with necrosis of adjacent soft tissue. Controversy surrounding appropriate early intervention in ORN persists and no consensus for clinical treatment has been established. In the present article, we review the pathophysiology of maxillary ORN and discuss the role of both conservative medical therapy and reconstruction.<\/jats:p>","DOI":"10.1055\/s-0040-1709144","type":"journal-article","created":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T22:31:02Z","timestamp":1588804262000},"page":"106-113","source":"Crossref","is-referenced-by-count":17,"title":["Osteoradionecrosis of the Maxilla: Conservative Management and Reconstructive Considerations"],"prefix":"10.1055","volume":"34","author":[{"given":"Tom","family":"Shokri","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weitao","family":"Wang","sequence":"additional","affiliation":[{"name":"Otolaryngology and Facial Plastic Surgery Associates, Fort Worth, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora","family":"Vincent","sequence":"additional","affiliation":[{"name":"Otolaryngology and Facial Plastic Surgery Associates, Fort Worth, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason E.","family":"Cohn","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Philadelphia College of Osteopathic Medicine, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameep","family":"Kadakia","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Wright State University, Dayton, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadranko","family":"Ducic","sequence":"additional","affiliation":[{"name":"Otolaryngology and Facial Plastic Surgery Associates, Fort Worth, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,5,6]]},"container-title":["Seminars in Plastic Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0040-1709144.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T22:31:17Z","timestamp":1588804277000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0040-1709144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2020,5,6]]},"published-print":{"date-parts":[[2020,5]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0040-1709144","relation":{},"ISSN":["1535-2188","1536-0067"],"issn-type":[{"value":"1535-2188","type":"print"},{"value":"1536-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5]]}}}