{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T10:27:54Z","timestamp":1781605674778,"version":"3.54.5"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"S 01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003Delayed maturation of auditory brainstem pathway in neonates admitted to the neonatal intensive care unit (NICU) may lead to misdiagnosis of children with normal peripheral hearing and inappropriate use of amplification devices. The aim of this study is to determine the pattern of auditory brain stem response in neonates admitted to the NICU for proper hearing assessment in this high-risk population.<\/jats:p><jats:p>\n          Study Design\u2003This prospective study was conducted on 1,469 infants who were admitted to the NICU, of which 1,423 had one or more risk factors for permanent congenital hearing loss and were screened with automated auditory brain stem response (AABR). A total of 60 infants were referred for diagnostic ABR analysis after failure on AABR screening. The control group comprised 60 well-baby nursery neonates with no risk factors for PCHL.<\/jats:p><jats:p>\n          Results\u2003Mean values of absolute latencies of waves III and V; interpeak latencies I\u2013III, III\u2013V, and I\u2013V; amplitude of waves I, and V; and I\/V amplitude ratio at 90\u2009dBnHL measured for the right and left ears at 1 and 3 months of age show significant difference in NICU neonates compared with controls (p &lt; 0.05). All the diagnostic ABR measurements significantly improved at the age of 3 months (p &lt; 0.001) except wave I absolute latency of both groups (p &gt; 0.05). Significant correlations were found between ABR readings at the age of 1 and 3 months and the gestational age of the NICU neonates (p &lt; 0.05).<\/jats:p><jats:p>\n          Conclusion\u2003Diagnostic ABR findings in NICU neonates suggested delayed maturation of the auditory brainstem pathway with a great impact of gestational age on this maturation. Auditory maturational changes were observed at 3 months of age of patient and control groups.<\/jats:p>","DOI":"10.1055\/s-0040-1709467","type":"journal-article","created":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T22:30:51Z","timestamp":1586557851000},"page":"e231-e238","source":"Crossref","is-referenced-by-count":4,"special_numbering":"S","title":["Auditory Brainstem Evoked Response Patterns in the Neonatal Intensive Care Unit"],"prefix":"10.1055","volume":"38","author":[{"given":"Somia Tawfik","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of ENT, Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7668-6649","authenticated-orcid":false,"given":"Rania Ali","family":"El-Farrash","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesham Mohammed","family":"Taha","sequence":"additional","affiliation":[{"name":"Department of ENT, Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omaima Ahmed","family":"Moustafa","sequence":"additional","affiliation":[{"name":"Department of ENT, Faculty of Medicine, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,4,10]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ijporl.2010.10.026","article-title":"An initial overestimation of sensorineural hearing loss in NICU infants after failure on neonatal hearing screening","volume":"75","author":"S Coenraad","year":"2011","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s13312-011-0067-0","article-title":"Early identification of hearing loss and centralized newborn hearing screening facility-the Cochin experience","volume":"48","author":"A K Paul","year":"2011","journal-title":"Indian Pediatr"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1111\/j.1749-6632.1982.tb50815.x","article-title":"Developmental dependencies of the human brainstem auditory evoked response","volume":"388","author":"K Hecox","year":"1982","journal-title":"Ann N Y Acad Sci"},{"issue":"02","key":"ref4","first-page":"71","article-title":"Prenatal iron deficiency and auditory brainstem responses at 3 and 10 months: a pilot study","volume":"20","author":"J Lou","year":"2016","journal-title":"Hong Kong J Paediatr"},{"issue":"08","key":"ref5","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1002\/lary.24054","article-title":"Auditory maturation in premature infants: a potential pitfall for early cochlear implantation","volume":"123","author":"J R Hof","year":"2013","journal-title":"Laryngoscope"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"7912127","DOI":"10.1155\/2017\/7912127","article-title":"Recovery of abnormal ABR in neonates and infants at risk of hearing loss","volume":"2017","author":"I Psarommatis","year":"2017","journal-title":"Int J Otolaryngol"},{"issue":"10","key":"ref7","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1002\/lary.22140","article-title":"Auditory brainstem response morphology and analysis in very preterm neonatal intensive care unit infants","volume":"121","author":"S Coenraad","year":"2011","journal-title":"Laryngoscope"},{"issue":"04","key":"ref8","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1542\/peds.2007-2333","article-title":"Year 2007 position statement: principles and guidelines for early hearing detection and intervention programs","volume":"120","year":"2007","journal-title":"Pediatrics"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1177\/000348948109000616","article-title":"Neural generators of brainstem evoked potentials. Results from human intracranial recordings","volume":"90","author":"A R M\u00f8ller","year":"1981","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"03","key":"ref10","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/00004691-198407000-00004","article-title":"Auditory brainstem potentials: comments on their use during infant development","volume":"1","author":"A Starr","year":"1984","journal-title":"J Clin Neurophysiol"},{"issue":"10","key":"ref11","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.earlhumdev.2014.07.014","article-title":"Auditory neural myelination is associated with early childhood language development in premature infants","volume":"90","author":"S B Amin","year":"2014","journal-title":"Early Hum Dev"},{"issue":"03","key":"ref12","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0022-3476(05)82056-6","article-title":"New Ballard Score, expanded to include extremely premature infants","volume":"119","author":"J L Ballard","year":"1991","journal-title":"J Pediatr"},{"issue":"05","key":"ref13","first-page":"1056","article-title":"A proposal for a new method of evaluation of the newborn infant. originally published in july 1953, volume 32, pages 250-259","volume":"120","author":"V Apgar","year":"2015","journal-title":"Anesth Analg"},{"issue":"07","key":"ref14","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1001\/archotol.1980.00790310011003","article-title":"Effects of age and sex on auditory brainstem response","volume":"106","author":"J Jerger","year":"1980","journal-title":"Arch Otolaryngol"},{"issue":"03","key":"ref15","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1542\/peds.2006-2174","article-title":"Auditory neural maturation after exposure to multiple courses of antenatal betamethasone in premature infants as evaluated by auditory brainstem response","volume":"119","author":"S B Amin","year":"2007","journal-title":"Pediatrics"},{"issue":"02","key":"ref16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3342\/ceo.2012.5.2.57","article-title":"Audiological follow-up results after newborn hearing screening program","volume":"5","author":"H W Lim","year":"2012","journal-title":"Clin Exp Otorhinolaryngol"},{"issue":"01","key":"ref17","first-page":"56","article-title":"Brainstem evoked auditory response in preterm and full-term infants","volume":"5","author":"L T Venkatesh","year":"2015","journal-title":"NJPPP"},{"issue":"05","key":"ref18","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1111\/j.1651-2227.1982.tb09508.x","article-title":"Auditory brainstem responses (ABR) in high-risk neonates","volume":"71","author":"S Mj\u00f8en","year":"1982","journal-title":"Acta Paediatr Scand"},{"issue":"09","key":"ref19","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/j.ijporl.2007.05.029","article-title":"Auditory brainstem response in premature and full-term children","volume":"71","author":"P Sleifer","year":"2007","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"05","key":"ref20","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1097\/00003446-199610000-00006","article-title":"Auditory brain stem response generation by parallel pathways: differential maturation of axonal conduction time and synaptic transmission","volume":"17","author":"C W Ponton","year":"1996","journal-title":"Ear Hear"},{"issue":"04","key":"ref21","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s00405-010-1415-8","article-title":"Incidence and clinical value of prolonged I-V interval in NICU infants after failing neonatal hearing screening","volume":"268","author":"S Coenraad","year":"2011","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"05","key":"ref22","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1542\/peds.72.5.658","article-title":"Auditory nerve-brainstem evoked responses in hyperbilirubinemic neonates","volume":"72","author":"M Perlman","year":"1983","journal-title":"Pediatrics"},{"issue":"05","key":"ref23","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.clinph.2011.08.032","article-title":"Functional abnormality of the auditory brainstem in high-risk late preterm infants","volume":"123","author":"Z D Jiang","year":"2012","journal-title":"Clin Neurophysiol"},{"issue":"06","key":"ref24","first-page":"729","article-title":"Auditory brainstem evoked response: response patterns of full-term and premature infants","volume":"76","author":"R L Casali","year":"2010","journal-title":"Rev Bras Otorrinolaringol (Engl Ed)"},{"issue":"04","key":"ref25","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1590\/S0103-05822013000400012","article-title":"Auditory brainstem response in neonates: influence of gender and weight\/gestational age ratio","volume":"31","author":"R M Angrisani","year":"2013","journal-title":"Rev Paul Pediatr"},{"issue":"09","key":"ref26","first-page":"1007","article-title":"Brainstem evoked response audiometry in neonates","volume":"27","author":"A K Gupta","year":"1990","journal-title":"Indian Pediatr"},{"issue":"01","key":"ref27","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0378-3782(95)01639-K","article-title":"Maturation of the auditory brainstem in low risk-preterm infants: a comparison with age-matched full term infants up to 6 years","volume":"42","author":"Z D Jiang","year":"1995","journal-title":"Early Hum Dev"},{"issue":"06","key":"ref28","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1203\/PDR.0b013e31819ed5ae","article-title":"Relative maturation of peripheral and central regions of the human brainstem from preterm to term and the influence of preterm birth","volume":"65","author":"Z D Jiang","year":"2009","journal-title":"Pediatr Res"},{"issue":"01","key":"ref29","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.earlhumdev.2012.07.012","article-title":"Sex and gestational age effects on auditory brainstem responses in preterm and term infants","volume":"89","author":"M Li","year":"2013","journal-title":"Early Hum Dev"},{"issue":"02","key":"ref30","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1469-8749.2002.tb00298.x","article-title":"Hearing loss in early infancy affects maturation of the auditory pathway","volume":"44","author":"D Tibussek","year":"2002","journal-title":"Dev Med Child Neurol"},{"issue":"05","key":"ref31","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/00003446-198810000-00009","article-title":"Development of ABR parameters in a preterm and a term born population","volume":"9","author":"J J Eggermont","year":"1988","journal-title":"Ear Hear"},{"issue":"01","key":"ref32","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1651-2227.2004.tb00679.x","article-title":"One-third of term babies after perinatal hypoxia-ischaemia have transient hearing impairment: dynamic change in hearing threshold during the neonatal period","volume":"93","author":"Z D Jiang","year":"2004","journal-title":"Acta Paediatr"},{"issue":"01","key":"ref33","first-page":"16","article-title":"Newborn hearing screening by transient evoked otoacoustic emissions: analysis of response as a function of risk factors","volume":"23","author":"B De Capua","year":"2003","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"ref34","first-page":"574937","article-title":"Targeted versus universal neonatal hearing screening in a single egyptian center","volume":"2013","author":"S S Imam","year":"2013","journal-title":"ISRN Pediatr"},{"issue":"01","key":"ref35","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1542\/peds.2007-0967","article-title":"Outcomes in a population of healthy term and near-term infants with serum bilirubin levels of >or=325 micromol\/L (>or=19\u2009mg\/dL) who were born in Nova Scotia, Canada, between 1994 and 2000","volume":"122","author":"K A Jangaard","year":"2008","journal-title":"Pediatrics"},{"key":"ref36","first-page":"167","article-title":"Estimating the incidence of neonatal hearing loss in high risk neonates","volume":"42","author":"A Zamani","year":"2004","journal-title":"Acta Med Iran"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0040-1709467.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T16:02:07Z","timestamp":1730822527000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0040-1709467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,10]]},"references-count":36,"journal-issue":{"issue":"S 01","published-online":{"date-parts":[[2021,8,27]]},"published-print":{"date-parts":[[2021,8]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0040-1709467","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,10]]}}}