{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T14:26:12Z","timestamp":1784903172219,"version":"3.55.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"05","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81970295"],"award-info":[{"award-number":["81970295"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81870267"],"award-info":[{"award-number":["81870267"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81570314"],"award-info":[{"award-number":["81570314"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81670318"],"award-info":[{"award-number":["81670318"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Grant of Shanghai Municipal Commission of Health and Family Planning","award":["2017YQ057"],"award-info":[{"award-number":["2017YQ057"]}]},{"name":"Grant of Shanghai Science and Technology Committee","award":["17411962300"],"award-info":[{"award-number":["17411962300"]}]},{"name":"National Program on Key Basic Research Project of China","award":["2014CBA02003"],"award-info":[{"award-number":["2014CBA02003"]}]},{"name":"Program for Outstanding Medical Academic Leader","award":["2015-Weijiwei-24"],"award-info":[{"award-number":["2015-Weijiwei-24"]}]},{"name":"Grant of Zhongshan Hospital Affiliated to Fudan University","award":["2015ZSYXGG07"],"award-info":[{"award-number":["2015ZSYXGG07"]}]},{"name":"Grant of Zhongshan Hospital Affiliated to Fudan University","award":["2017ZSYQ08"],"award-info":[{"award-number":["2017ZSYQ08"]}]},{"name":"VG Funding of Clinical Trials","award":["2017-CCA-VG-036"],"award-info":[{"award-number":["2017-CCA-VG-036"]}]},{"name":"Merck Funding","award":["Xinxin-merck-fund-051"],"award-info":[{"award-number":["Xinxin-merck-fund-051"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Cilostazol-based dual antiplatelet therapy (DAPT) is widely used in patients with aspirin intolerance after coronary drug-eluting stent (DES) implantation in China. However, this empirical strategy is not recommended or even mentioned in Chinese or international guidelines due to a lack of evidence from large-scale studies. We aimed to explore the efficacy and safety of cilostazol-based DAPT in this special population.<\/jats:p><jats:p>\n          Methods\u2003In this cohort study, patients were grouped according to the DAPT strategy that they received after coronary DES implantation. The primary efficacy endpoint was major adverse cardiovascular and cerebrovascular events (MACCEs). Angiographic follow-up and major bleeding events were also recorded.<\/jats:p><jats:p>\n          Results\u2003A total of 918 patients receiving cilostazol-based DAPT due to aspirin intolerance were enrolled, matched with 918 patients receiving aspirin-based DAPT. After 15-month prospective follow-up, the cilostazol group had lower risk of MACCE (5.1% vs. 7.6%, propensity score adjusted hazard ratio\u2009=\u20090.671 [95% confidence interval 0.462\u20130.974], p\u2009=\u20090.036) compared with the aspirin group. Lower rate of coronary lesion progression was also found through follow-up angiography in the cilostazol group (17.4% vs. 23.6%, p\u2009=\u20090.022), especially in nontarget lesions (12.1% vs. 17.6%, p\u2009=\u20090.019). The two groups had the same risk of major bleeding events (0.8% vs. 0.4%, p\u2009=\u20090.364).<\/jats:p><jats:p>\n          Conclusion\u2003In the current study, cilostazol is a good substitute for aspirin in patients who have aspirin intolerance but need DAPT after coronary DES implantation in China. However, large-scale randomized controlled trials were still required to further confirm its efficacy and safety.<\/jats:p>","DOI":"10.1055\/s-0040-1709520","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T22:37:44Z","timestamp":1588718264000},"page":"857-865","source":"Crossref","is-referenced-by-count":13,"title":["Cilostazol for Chinese Patients with Aspirin Intolerance after Coronary Drug-Eluting Stent Implantation"],"prefix":"10.1055","volume":"120","author":[{"given":"Chunfeng","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangwei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Fu","sequence":"additional","affiliation":[{"name":"Shanghai Medical College, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juying","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbo","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,5,5]]},"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0040-1709520.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T22:38:27Z","timestamp":1588718307000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0040-1709520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":0,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2020,5,5]]},"published-print":{"date-parts":[[2020,5]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0040-1709520","relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5]]}}}