{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:10:45Z","timestamp":1724285445728},"reference-count":76,"publisher":"Georg Thieme Verlag KG","issue":"04","funder":[{"name":"NIH","award":["R24OD017870"],"award-info":[{"award-number":["R24OD017870"]}]},{"name":"NIH","award":["R01DK090311"],"award-info":[{"award-number":["R01DK090311"]}]},{"name":"NIH","award":["R01DK105198"],"award-info":[{"award-number":["R01DK105198"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Liver Dis"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hepatocytes and biliary epithelial cells (BECs), the two endodermal cell types of the liver, originate from progenitor cells called hepatoblasts. Based principally on in vitro data, hepatoblasts are thought to be bipotent stem cells with the potential to produce both hepatocytes and BECs. However, robust in vivo evidence for this model has only recently emerged. We examine the molecular mechanisms that stimulate hepatoblast differentiation into hepatocytes or BECs. In the absence of extrinsic cues, the default fate of hepatoblasts is hepatocyte differentiation. Inductive cues from the hepatic portal vein, however, initiate transcription factor expression in hepatoblasts, driving biliary specification. Defining the mechanisms of hepatobiliary differentiation provides important insights into congenital disorders, such as Alagille syndrome, and may help to better characterize the poorly understood hepatic lineage relationships observed during regeneration from liver injury.<\/jats:p>","DOI":"10.1055\/s-0040-1709679","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T22:42:19Z","timestamp":1591915339000},"page":"365-372","source":"Crossref","is-referenced-by-count":2,"title":["Hepatobiliary Differentiation: Principles from Embryonic Liver Development"],"prefix":"10.1055","volume":"40","author":[{"given":"Scott H.","family":"Freeburg","sequence":"additional","affiliation":[{"name":"Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfram","family":"Goessling","sequence":"additional","affiliation":[{"name":"Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts"},{"name":"Broad Institute of MIT and Harvard, Cambridge, Massachusetts"},{"name":"Harvard Stem Cell Institute, Cambridge, Massachusetts"},{"name":"Dana-Farber Cancer Institute, Boston, Massachusetts"},{"name":"Harvard-MIT Division of Health Science and Technology, Cambridge, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,6,11]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/ng0797-243","article-title":"Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1","volume":"16","author":"L Li","year":"1997","journal-title":"Nat Genet"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/ng0797-235","article-title":"Mutations in the human Jagged1 gene are responsible for Alagille syndrome","volume":"16","author":"T Oda","year":"1997","journal-title":"Nat Genet"},{"issue":"23","key":"ref3","doi-asserted-by":"crossref","first-page":"4061","DOI":"10.1242\/dev.052118","article-title":"Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome","volume":"137","author":"J J Hofmann","year":"2010","journal-title":"Development"},{"issue":"12","key":"ref4","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1242\/dev.114215","article-title":"Orchestrating liver development","volume":"142","author":"M Gordillo","year":"2015","journal-title":"Development"},{"issue":"02","key":"ref6","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/aja.1001310202","article-title":"A morphological study of the development of the human liver. 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