{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:54:46Z","timestamp":1792068886264,"version":"4.4.0"},"reference-count":32,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"05","license":[{"start":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T00:00:00Z","timestamp":1590710400000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Objective\u2003Missed abortion occurs in \u223c 15% of all clinical pregnancies. The pathogenesis is not clearly known. However, defective placentation resulting in maternal systemic inflammatory response is considered responsible for missed abortion. Platelet lymphocyte ratio (PLR) and neutrophil lymphocyte ratio (NLR) are increasingly cited parameters of inflammation in the literature. However, no study evaluated the PLR and NLR rates in missed abortions so far. The aim of the present study is to investigate whether complete blood count (CBC) inflammatory parameters such as NLR and PLR are increased in patients with missed abortion.<\/jats:p>\n                  <jats:p>Methods\u2003Medical records of 40 pregnant women whose gestation ended in missed abortion at between 6 and14 weeks of gestation and of 40 healthy pregnant women were collected and compared retrospectively. The groups were compared regarding hemoglobin, hematocrit, platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), PLR and NLR.<\/jats:p>\n                  <jats:p>Results\u2003Platelet distribution width, NLR and PLR values were higher in the missed abortion group compared with the healthy pregnant women group (rates are p\u2009=\u20090.043; p\u2009=\u20090.038; and p\u2009=\u20090.010, respectively). Hematocrit, MPV, and lymphocyte values were found to be lower in the missed abortion group compared with the healthy pregnant women group (p\u2009=\u20090.027, p\u2009=\u20090.044 and p\u2009=\u20090.025, respectively).<\/jats:p>\n                  <jats:p>Conclusion\u2003The PDW, NLR and PLR values of the missed abortion group were reported high; and MPV values were reported low in the present study. These findings may help to speculate a defective placentation in the pathogenesis of missed abortion.<\/jats:p>","DOI":"10.1055\/s-0040-1709693","type":"journal-article","created":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T19:30:20Z","timestamp":1591299020000},"page":"235-239","source":"Crossref","is-referenced-by-count":29,"title":["Platelet to Lymphocyte Ratio and Neutrophil to Lymphocyte Ratio in Missed Abortion"],"prefix":"10.61622","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6111-9302","authenticated-orcid":false,"given":"Ismail","family":"Biyik","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine, K\u00fctahya Health Sciences University, K\u00fctahya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2941-7574","authenticated-orcid":false,"given":"Mustafa","family":"Albayrak","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Florence Nightingale Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3569-0307","authenticated-orcid":false,"given":"Fatih","family":"Keskin","sequence":"additional","affiliation":[{"name":"Private Balkan Hospital, Edirne, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"47794","published-online":{"date-parts":[[2020,5,29]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1056\/NEJM198807283190401","article-title":"Incidence of early loss of pregnancy","volume":"319","author":"A J Wilcox","year":"1988","journal-title":"N Engl J Med"},{"issue":"04","key":"ref3","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1067\/S0002-9378(03)00838-X","article-title":"Failure of physiologic transformation of the spiral arteries in patients with preterm labor and intact membranes","volume":"189","author":"Y M 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Pathol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.placenta.2004.05.011","article-title":"Pathophysiology of histological changes in early pregnancy loss","volume":"26","author":"E Jauniaux","year":"2005","journal-title":"Placenta"},{"issue":"04","key":"ref8","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0015-0282(01)02002-7","article-title":"Maternal serum levels of tumor necrosis factor-alpha and interleukin-2 receptor in threatened abortion: a comparison with normal and pathologic pregnancies","volume":"76","author":"F G\u00fccer","year":"2001","journal-title":"Fertil Steril"},{"issue":"04","key":"ref9","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1034\/j.1600-0897.2003.00065.x","article-title":"Maternal serum levels of pro-inflammatory cytokines in missed and threatened abortion","volume":"50","author":"R Paradisi","year":"2003","journal-title":"Am J Reprod 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Pract"},{"issue":"02","key":"ref13","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/00001721-199603000-00011","article-title":"Platelet size: measurement, physiology and vascular disease","volume":"7","author":"P M Bath","year":"1996","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"01","key":"ref14","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1080\/09537100075760","article-title":"Shape change in human platelets: measurement with a channelyzer and visualisation by electron microscopy","volume":"11","author":"I A Jagroop","year":"2000","journal-title":"Platelets"},{"issue":"01","key":"ref15","first-page":"108","article-title":"The relationship between megakaryocyte ploidy and platelet volume","volume":"15","author":"J Martin","year":"1989","journal-title":"Blood Cells"},{"issue":"01","key":"ref16","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0950-3536(97)80053-4","article-title":"Megakaryocytes and platelets in vascular disease","volume":"10","author":"B van der Loo","year":"1997","journal-title":"Baillieres Clin Haematol"},{"issue":"06","key":"ref17","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1093\/humupd\/dml016","article-title":"Placental-related diseases of pregnancy: Involvement of oxidative stress and implications in human evolution","volume":"12","author":"E Jauniaux","year":"2006","journal-title":"Hum Reprod Update"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.preghy.2016.12.002","article-title":"Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, mean platelet volume, red cell distribution width and plateletcrit in preeclampsia","volume":"7","author":"B Y\u00fccel","year":"2017","journal-title":"Pregnancy Hypertens"},{"issue":"07","key":"ref19","doi-asserted-by":"crossref","first-page":"503","DOI":"10.3109\/10641963.2013.863324","article-title":"New inflammatory markers in pre-eclampsia: echocardiographic epicardial fat thickness and neutrophil to lymphocyte ratio","volume":"36","author":"M Oylumlu","year":"2014","journal-title":"Clin Exp Hypertens"},{"issue":"06","key":"ref20","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.placenta.2009.02.009","article-title":"Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy","volume":"30","author":"G J Burton","year":"2009","journal-title":"Placenta"},{"issue":"01","key":"ref21","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0002-9440(10)63803-5","article-title":"Trophoblastic oxidative stress in relation to temporal and regional differences in maternal placental blood flow in normal and abnormal early pregnancies","volume":"162","author":"E Jauniaux","year":"2003","journal-title":"Am J Pathol"},{"issue":"02","key":"ref22","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.tjog.2014.03.006","article-title":"Evaluation of maternal 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