{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:57:49Z","timestamp":1740142669673,"version":"3.37.3"},"reference-count":16,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"04","license":[{"start":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T00:00:00Z","timestamp":1587686400000},"content-version":"vor","delay-in-days":23,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The present report describes a case of complete atrioventricular block (CAVB) diagnosed at 25 weeks of gestation in a pregnant woman with Sj\u00f6gren's syndrome and positive anti-Ro\/SSA antibodies. Fluorinated steroids (dexamethasone and betamethasone) and terbuline were used to increase the fetal heart rate, but the fetal heart block was not reversible, and the administration of drugs was discontinued due to maternal collateral effects. Follow-up fetal echocardiograms were performed, and the fetus evolved with pericardial effusion, presence of fibroelastosis in the right ventricle, and ventricular dysfunction. Interruption of pregnancy by cesarean section was indicated at 34 weeks of gestation, and a cardiac pacemaker was implanted in the male newborn immediately after birth. Therapy for fetuses with CAVB is controversial mainly regarding the use or not of corticosteroids; however, monitoring of the atrioventricular interval by fetal echocardiography should be performed in fetuses from pregnant women with positive autoantibodies anti-Ro\/SSA and\/or anti-La\/SSB to prevent the progression to CAVB.<\/jats:p>","DOI":"10.1055\/s-0040-1709738","type":"journal-article","created":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T23:31:40Z","timestamp":1587771100000},"page":"228-232","source":"Crossref","is-referenced-by-count":4,"title":["Congenital Complete Atrioventricular Heart Block in a Pregnant Woman with Sj\u00f6gren Syndrome: Prenatal Care Follow-Up and the Challenge of Intrauterine Treatment"],"prefix":"10.61622","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6138-8182","authenticated-orcid":false,"given":"Milene Carvalho","family":"Carrilho","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1491-4877","authenticated-orcid":false,"given":"Nathalie Jeanne","family":"Bravo-Valenzuela","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6145-2532","authenticated-orcid":false,"given":"Edward","family":"Araujo J\u00fanior","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"47794","published-online":{"date-parts":[[2020,4,24]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.hrthm.2012.12.030","article-title":"Pathophysiology, clinical course, and management of congenital complete atrioventricular block","volume":"10","author":"P Bordachar","year":"2013","journal-title":"Heart Rhythm"},{"issue":"05","key":"ref2","first-page":"600","article-title":"Brazilian Fetal Cardiology Guidelines - 2019","volume":"112","author":"S RFF Pedra","year":"2019","journal-title":"Arq Bras Cardiol"},{"issue":"21","key":"ref3","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1161\/01.cir.0000437597.44550.5d","article-title":"Diagnosis and treatment of fetal cardiac disease: a scientific statement from the American Heart Association","volume":"129","author":"M T Donofrio","year":"2014","journal-title":"Circulation"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"16","DOI":"10.7812\/TPP\/16-047","article-title":"Sj\u00f6gren syndrome and pregnancy: a literature review","volume":"21","author":"S Gupta","year":"2017","journal-title":"Perm J"},{"issue":"04","key":"ref5","doi-asserted-by":"crossref","first-page":"569","DOI":"10.3109\/14397595.2015.1106661","article-title":"Maternal predictive factors for fetal congenital heart block in pregnant mothers positive for anti-SS-A antibodies","volume":"26","author":"H Tsuboi","year":"2016","journal-title":"Mod Rheumatol"},{"issue":"01","key":"ref6","first-page":"22","article-title":"[Intrauterine therapy and outcome in four pregnancies of one mother with anti ro-autoantibody positive Sjoegren's syndrome]","volume":"206","author":"M Zemlin","year":"2002","journal-title":"Z Geburtshilfe Neonatol"},{"issue":"05","key":"ref7","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1253\/circj.CJ-10-1032","article-title":"Fetal echocardiographic assessment of endocardial fibroelastosis in maternal anti-SSA antibody-associated complete heart block","volume":"75","author":"H Aoki","year":"2011","journal-title":"Circ J"},{"issue":"07","key":"ref8","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1161\/hc0702.104182","article-title":"Maternal anti-Ro and anti-La antibody-associated endocardial fibroelastosis","volume":"105","author":"L E Nield","year":"2002","journal-title":"Circulation"},{"issue":"18","key":"ref9","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1161\/CIRCULATIONAHA.111.041970","article-title":"Isolated atrioventricular block in the fetus: a retrospective, multinational, multicenter study of 175 patients","volume":"124","author":"H Eliasson","year":"2011","journal-title":"Circulation"},{"issue":"12","key":"ref10","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1161\/CIRCULATIONAHA.107.735118","article-title":"Perinatal outcome of fetal atrioventricular block: one-hundred-sixteen cases from a single institution","volume":"118","author":"L M Lopes","year":"2008","journal-title":"Circulation"},{"issue":"18","key":"ref11","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1161\/CIRCULATIONAHA.111.061267","article-title":"Ineffective therapy, underpowered studies, or merely too little, too late? Risk factors and impact of maternal corticosteroid treatment on outcome in antibody-associated fetal heart block","volume":"124","author":"J I Pike","year":"2011","journal-title":"Circulation"},{"issue":"02","key":"ref12","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1159\/000052960","article-title":"Treatment of fetal congenital complete heart block with maternal administration of beta-sympathomimetics (terbutaline): a case report","volume":"52","author":"H Yoshida","year":"2001","journal-title":"Gynecol Obstet Invest"},{"issue":"07","key":"ref13","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1080\/14767050600682446","article-title":"A cardiovascular profile score in the surveillance of fetal hydrops","volume":"19","author":"C Hofstaetter","year":"2006","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bpobgyn.2019.01.007","article-title":"In utero intervention for severe congenital heart disease","volume":"58","author":"H M Gardiner","year":"2019","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"14","key":"ref15","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1161\/CIRCULATIONAHA.108.773143","article-title":"Early diagnosis and treatment of atrioventricular block in the fetus exposed to maternal anti-SSA\/Ro-SSB\/La antibodies: a prospective, observational, fetal kinetocardiogram-based study","volume":"119","author":"A JJT Rein","year":"2009","journal-title":"Circulation"},{"issue":"03","key":"ref16","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1136\/annrheumdis-2016-209770","article-title":"EULAR recommendations for women's health and the management of family planning, assisted reproduction, pregnancy and menopause in patients with systemic lupus erythematosus and\/or antiphospholipid syndrome","volume":"76","author":"L Andreoli","year":"2017","journal-title":"Ann Rheum Dis"}],"container-title":["Revista Brasileira de Ginecologia e Obstetr\u00edcia \/ RBGO Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journalrbgo.org\/article\/congenital-complete-atrioventricular-heart-block-in-a-pregnant-woman-with-sjogren-syndrome-prenatal-care-follow-up-and-the-challenge-of-intrauterine-treatment\/","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0040-1709738.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T20:57:23Z","timestamp":1721336243000},"score":1,"resource":{"primary":{"URL":"https:\/\/journalrbgo.org\/article\/congenital-complete-atrioventricular-heart-block-in-a-pregnant-woman-with-sjogren-syndrome-prenatal-care-follow-up-and-the-challenge-of-intrauterine-treatment\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":16,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2020,4,24]]},"published-print":{"date-parts":[[2020,4]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0040-1709738","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0100-7203","1806-9339"],"issn-type":[{"type":"print","value":"0100-7203"},{"type":"electronic","value":"1806-9339"}],"subject":[],"published":{"date-parts":[[2020,4]]}}}