{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T02:16:32Z","timestamp":1758161792723,"version":"3.44.0"},"reference-count":15,"publisher":"Mathematical Modelling and Numerical Simulation with Applications","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Pediatr Intensive Care"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Inhaled nitric oxide (iNO) may be continued during the transition from invasive to noninvasive respiratory support. Upper airway obstruction from laryngeal edema following extubation and lower airway obstruction from asthma and bronchiolitis may be managed with inhaled helium. The coadministration of helium with iNO and the impact on delivered amounts of iNO have not been extensively studied. A bench model simulating a spontaneously breathing infant received iNO at varying preset doses delivered with either helium-oxygen or nitrogen-oxygen via a Vapotherm unit. iNO levels were measured at the simulated trachea. Results from the two conditions were compared using t-tests. When nitrogen-oxygen was used, there was no difference between preset and measured iNO levels. A significant difference was present when helium-oxygen was used, with a 10-fold increase in measured iNO levels compared with preset values. The use of helium resulted in a significant increase in measured iNO at the level of the simulated trachea. Clinicians must be aware that iNO will not be delivered at prescribed doses when used with helium under the conditions used in this study.<\/jats:p>","DOI":"10.1055\/s-0040-1710057","type":"journal-article","created":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T19:58:38Z","timestamp":1587758318000},"page":"261-264","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Helium-Oxygen Administered via High Velocity Nasal Insufflation on Delivery of Inhaled Nitric Oxide"],"prefix":"10.53391","volume":"09","author":[{"given":"James H.","family":"Hertzog","sequence":"additional","affiliation":[{"name":"Respiratory Care Services, Nemours\/Alfred I. duPont Hospital for Children, Wilmington, Delaware, United States"},{"name":"Division of Critical Care Medicine, Department of Pediatrics, Nemours\/Alfred I. duPont Hospital for Children, Wilmington, Delaware, United States"},{"name":"Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katlyn L.","family":"Burr","sequence":"additional","affiliation":[{"name":"Respiratory Care Services, Nemours\/Alfred I. duPont Hospital for Children, Wilmington, Delaware, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Stump","sequence":"additional","affiliation":[{"name":"Respiratory Care Services, Nemours\/Alfred I. duPont Hospital for Children, Wilmington, Delaware, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel M.","family":"Brown","sequence":"additional","affiliation":[{"name":"Respiratory Care Services, Nemours\/Alfred I. duPont Hospital for Children, Wilmington, Delaware, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Penfil","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Samuelson Children's Hospital at Sinai, Baltimore, Maryland, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly","family":"McMahon","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, Department of Pediatrics, Nemours\/Alfred I. duPont Hospital for Children, Wilmington, Delaware, United States"},{"name":"Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"31409","published-online":{"date-parts":[[2020,4,24]]},"reference":[{"key":"ref1","first-page":"978","article-title":"Inhaled nitric oxide: medical miracle or passing fad?","volume":"43","author":"H J Dalton","year":"1998","journal-title":"Respir Care"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.4187\/respcare.03278","article-title":"Nitric oxide delivery by neonatal noninvasive respiratory support devices","volume":"60","author":"R M 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