{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T16:33:30Z","timestamp":1777307610956,"version":"3.51.4"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T00:00:00Z","timestamp":1590019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Dent"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\nObjectives\u2003The present study aimed to investigate osteocalcin levels in saliva of healthy and periodontitis patients and correlate these levels with periodontitis severity.<\/jats:p><jats:p>\nMaterials and Methods\u2003This cross-sectional study was conducted in a hospital setup. A total of 95 individuals participated in the study with 46 subjects in group I (healthy individuals) and 49 subjects in group II (mild, moderate, and severe chronic periodontitis patients). A detailed assessment of clinical periodontal parameters and alveolar bone loss was made. Unstimulated saliva samples were collected from all study subjects and osteocalcin levels were quantitatively analyzed by sandwich enzyme-linked immunosorbent essay technique.<\/jats:p><jats:p>\nStatistical Analysis\u2003One-way analysis of variance, Spearman\u2019s correlation test, and Pearson\u2019s chi-squared test were applied at a significance level of 95%. p-Values less than 0.05 were considered statistically significant.<\/jats:p><jats:p>\nResults\u2003The results showed a significant association of qualification with group II (p &lt; 0.02). Bone loss scores were also significantly associated with periodontitis severity (p &lt; 0.01). However, no statistically significant difference was observed between group I and group II in terms of mean salivary osteocalcin levels (p = 0.68). Also, an insignificant correlation was also observed between osteocalcin levels and periodontitis severity (p = 0.13).<\/jats:p><jats:p>\nConclusion\u2003The overall study results showed that there was no significant difference between saliva osteocalcin levels of healthy and periodontitis patients. Also, there was a nonsignificant correlation between osteocalcin levels and periodontitis severity. The findings of the present study support the hypothesis that low osteocalcin levels in saliva might be considered as a poor indicator of periodontal disease progression and severity.<\/jats:p>","DOI":"10.1055\/s-0040-1710143","type":"journal-article","created":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T22:53:45Z","timestamp":1590101625000},"page":"352-359","source":"Crossref","is-referenced-by-count":12,"title":["Evaluation of Osteocalcin Levels in Saliva of Periodontitis Patients and Their Correlation with the Disease  Severity: A Cross-Sectional Study"],"prefix":"10.1055","volume":"14","author":[{"given":"Hamda","family":"Shazam","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, College of Dentistry, Ziauddin University, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fouzia","family":"Shaikh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ziauddin University, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaheer","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Altamash Institute of Dental Medicine, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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