{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T16:10:13Z","timestamp":1792253413948,"version":"4.4.0"},"reference-count":34,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"05","license":[{"start":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T00:00:00Z","timestamp":1590710400000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Intrauterine growth restriction (IUGR) is associated with poor perinatal prognosis and a higher risk of stillbirth, neonatal death, and cerebral palsy. Its detection and the evaluation of its severity by new Doppler velocimetric parameters, such as aortic isthmus (AoI), are of great relevance for obstetrical practice. The AoI is a vascular segment that represents a point of communication between the right and left fetal circulations. It is considered to be a functional arterial shunt that reflects the relationship between the systemic and cerebral impedances, and has recently been proposed as a tool to detect the status of hemodynamic balance and prognosis of IUGR in fetuses. In the present review, we noticed that in healthy fetuses, the AoI net flow is always antegrade, but in fetuses with IUGR the deterioration of placental function leads to progressive reduction in its flow until it becomes mostly retrograde; this point is associated with a drastic reduction in oxygen delivery to the brain. The more impaired the AoI flow is, the greater is the risk of impairment in the Doppler velocimetry of other vessels; and the alterations of the AoI Doppler seem to precede other indicators of severe hypoxemia. Although there seems to be an association between the presence of retrograde flow in the AoI and the risk of long-term neurologic disability, its role in the prediction of perinatal morbi-mortality remains unclear. The AoI Doppler seems to be a promising tool in the management of fetuses with IUGR, but more studies are needed to investigate its employment in clinical practice.<\/jats:p>","DOI":"10.1055\/s-0040-1710301","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T05:43:35Z","timestamp":1591076615000},"page":"289-296","source":"Crossref","is-referenced-by-count":15,"title":["Aortic Isthmus Doppler Velocimetry in Fetuses with Intrauterine Growth Restriction: A Literature Review"],"prefix":"10.61622","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3206-9171","authenticated-orcid":false,"given":"Mariana Martins","family":"Ferraz","sequence":"additional","affiliation":[{"name":"Fetal Medicine Post Graduation, Universidade Est\u00e1cio de S\u00e1, Rio de Janeiro, RJ, Brazil"},{"name":"Cl\u00ednica Perinatal, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3004-4376","authenticated-orcid":false,"given":"Fl\u00e1via do Vale","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Fetal Medicine Post Graduation, Universidade Est\u00e1cio de S\u00e1, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7835-4656","authenticated-orcid":false,"given":"Paulo Roberto Nassar de","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Fetal Medicine Post Graduation, Universidade Est\u00e1cio de S\u00e1, Rio de Janeiro, RJ, Brazil"},{"name":"Fetal Medicine Department, Instituto Fernandes Figueira, Rio de Janeiro, RJ, Brazil"},{"name":"Cl\u00ednica Perinatal, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0885-2457","authenticated-orcid":false,"given":"Renato Augusto Moreira de","family":"S\u00e1","sequence":"additional","affiliation":[{"name":"Fetal Medicine Department, Instituto Fernandes Figueira, Rio de Janeiro, RJ, Brazil"},{"name":"Fetal Medicine Department, Instituto Fernandes Figueira, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"47794","published-online":{"date-parts":[[2020,5,29]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/ajo.12264","article-title":"Shining light in dark corners: diagnosis and management of late-onset fetal growth restriction","volume":"55","author":"T M MacDonald","year":"2015","journal-title":"Aust N Z J Obstet Gynaecol"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1159\/000357592","article-title":"Update on the diagnosis and classification of fetal growth restriction and proposal of a stage-based management protocol","volume":"36","author":"F 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