{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:19:47Z","timestamp":1759742387277,"version":"3.37.3"},"reference-count":34,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"05","license":[{"start":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T00:00:00Z","timestamp":1590710400000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003To compare the effect of high-dose vitamin A (HD Vit-A) use during postmolar follow-up of patients with low and plateauing (L&amp;P) serum human chorionic gonadotropin (hCG) levels, from the moment serum hCG plateaued (P-hCG) to the first normal serum hCG value (&lt; 5\u2009IU\/L).<\/jats:p><jats:p>\n          Methods\u2003The present retrospective series case study compared two nonconcurrent cohorts of patients. Control group (CG): 34 patients with L&amp;P serum hCG levels who underwent expectant management for 6 months after uterine evacuation, from 1992 to 2010; study group (SG): 32 patients in similar conditions who received 200,000\u2009IU of Vit-A daily, from the identification of a P-hCG level to the first normal hCG value or the diagnosis of progression to gestational trophoblastic neoplasia (GTN), from 2011 to 2017. The present study was approved by the Ethics Committee of the institution where it was conducted.<\/jats:p><jats:p>\n          Results\u2003In both groups, the prevalence of persistent L&amp;P serum hCG levels was\u2009&lt;\u20095%. In the SG, hCG levels at plateau were higher (CG\u2009=\u200985.5 versus SG\u2009=\u2009195\u2009IU\/L; p\u2009=\u20090.028), the rate of postmolar GTN was lower (CG\u2009=\u200929.4% versus SG\u2009=\u20096.3%, p\u2009=\u20090.034) and follow-up was shorter (CG\u2009=\u200914 versus SG\u2009=\u200910 months, p\u2009&lt;\u20090.001). During GTN follow-up, there were no differences in GTN staging or treatment aggressiveness in both groups. High-dose Vit-A use did not have any relevant toxic effect. There were no GTN relapses or deaths.<\/jats:p><jats:p>\n          Conclusion\u2003The limited use of HD Vit-A seems to have a safe and significant effect on the treatment of postmolar patients with L&amp;P serum hCG levels and may decrease the development of postmolar GTN in this population.<\/jats:p>","DOI":"10.1055\/s-0040-1710302","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T05:43:35Z","timestamp":1591076615000},"page":"240-247","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of High-Dose Vitamin A Treatment in Postmolar Patients with Low and Plateauing Serum Human Chorionic Gonadotropin Levels"],"prefix":"10.61622","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3087-8573","authenticated-orcid":false,"given":"Elza Maria Hartmann","family":"Uberti","sequence":"additional","affiliation":[{"name":"Porto Alegre Trophoblastic Disease Center, Mario Totta Maternity Ward, Hospital Irmandade da Santa Casa de Miseric\u00f3rdia, Porto Alegre, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5863-1062","authenticated-orcid":false,"given":"Ruth Karina Escobar","family":"Diaz","sequence":"additional","affiliation":[{"name":"Porto Alegre Trophoblastic Disease Center, Mario Totta Maternity Ward, Hospital Irmandade da Santa Casa de Miseric\u00f3rdia, Porto Alegre, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7021-4571","authenticated-orcid":false,"given":"Rodrigo Bernardes","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Porto Alegre Trophoblastic Disease Center, Mario Totta Maternity Ward, Hospital Irmandade da Santa Casa de Miseric\u00f3rdia, Porto Alegre, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2942-6182","authenticated-orcid":false,"given":"Antonio","family":"Braga","sequence":"additional","affiliation":[{"name":"Rio de Janeiro Gestational Trophoblastic Disease Reference Center, Department of Obstetrics and Gynecology, Maternity School, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"47794","published-online":{"date-parts":[[2020,5,29]]},"reference":[{"issue":"S 02","key":"ref1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/ijgo.12615","article-title":"Update on the diagnosis and management of gestational trophoblastic disease","volume":"143","author":"H YS Ngan","year":"2018","journal-title":"Int J Gynaecol Obstet"},{"issue":"06","key":"ref2","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.ajog.2010.06.073","article-title":"Gestational trophoblastic 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