{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:18:36Z","timestamp":1785449916414,"version":"3.56.0"},"reference-count":44,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Acute kidney injury is a serious complication after surgical valve replacement and holds increased mortality rates.<\/jats:p><jats:p>\n          Objectives\u2003To study predictors of acute kidney injury after surgical valve replacement.<\/jats:p><jats:p>\n          Materials and Methods\u2003Patients who underwent valve surgery procedures at our center were included. Procedures included aortic valve replacement (AVR), mitral valve replacement (MVR), AVR with coronary artery bypass grafting (CABG), MVR with CABG, or AVR and MVR with\/without CABG.<\/jats:p><jats:p>\n          Results\u2003A total of 346 patients were included. The mean age was 51.56 (16.1). Males (n\u2009=\u2009178) comprised 51%.<\/jats:p><jats:p>At the univariate level analysis, predictors of acute kidney injury were found including age, ejection fraction, hypertension, history of CAD, emergency surgery, recent myocardial infarction, diabetes, atrial fibrillation, history of heart failure, mitral regurgitation (MR), pump time &gt;120\u2009minutes, aortic cross clamp &gt;90\u2009minutes, perioperative blood transfusion, re-exploration for bleeding, use of mechanical and biologic valve in aortic position, use of biologic valve in mitral position, prolonged inotropic support, postoperative stroke, and use of angiotensin converting enzyme inhibitors (ACEi)\u2009&lt;\u2009a month, (all p\u2009&lt;\u20090.05).<\/jats:p><jats:p>By Logistic regression analysis, Age (p\u2009&lt;\u20090.0001, odds ratio[AOR]\u2009=\u20091.076), hypertension (p\u2009=\u20090.039, AOR\u2009=\u20091.829), heart failure (p\u2009=\u20090.019, AOR\u2009=\u20092.448), MR (p\u2009=\u20090.0001, AOR\u2009=\u20093.110), use of ACEi &lt;month (p\u2009=\u20090.043, AOR= 2.181), pump time &gt;120\u2009minutes (p\u2009=\u20090.022, AOR\u2009=\u20091.797), perioperative blood transfusion (p\u2009=\u20090.008, AOR\u2009=\u20092.532), and prolonged inotropic support (p\u2009=\u20090.012, AOR\u2009=\u20092.591) were significant and independent predictors of AKI.<\/jats:p><jats:p>\n          Conclusion\u2003Independent predictors of acute kidney injury following valve surgeries include age, hypertension, heart failure, MR, use of ACEi &lt;month, perioperative blood transfusion, and prolonged pump time or inotropic support.<\/jats:p>","DOI":"10.1055\/s-0040-1710318","type":"journal-article","created":{"date-parts":[[2020,7,25]],"date-time":"2020-07-25T22:30:51Z","timestamp":1595716251000},"page":"396-404","source":"Crossref","is-referenced-by-count":7,"title":["Predictors of Acute Kidney Injury Following Surgical Valve Replacement"],"prefix":"10.1055","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9738-2575","authenticated-orcid":false,"given":"Khalid S.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of General Surgery and Urology, College of Medicine, Jordan University of Science and Technology, Irbid, Jordan"},{"name":"Princess Muna Center for Heart Diseases and Surgery, King Abdullah University Hospital, Irbid, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid A.","family":"Kheirallah","sequence":"additional","affiliation":[{"name":"Department of Public Health and Community Health, College of Medicine, Jordan University of Science and Technology, Irbid, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadia A.","family":"Mayyas","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, College of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nizar A.","family":"Alwaqfi","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery, Department of General Surgery and Urology, College of Medicine, Jordan University of Science and Technology, Irbid, Jordan"},{"name":"Princess Muna Center for Heart Diseases and Surgery, King Abdullah University Hospital, Irbid, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,7,25]]},"reference":[{"issue":"18","key":"ref1","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1161\/CIRCULATIONAHA.108.800011","article-title":"Acute kidney injury is associated with increased long-term mortality after cardiothoracic surgery","volume":"119","author":"C E 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