{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T18:30:04Z","timestamp":1788978604325,"version":"build-2803163510"},"reference-count":63,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropediatrics"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Cardiac disorders are the second leading cause of pediatric arterial ischemic stroke (AIS). Limited literature is available on pediatric AIS caused by cardiac myxoma, a rare tumor in childhood.<\/jats:p><jats:p>\n          Methods\u2003We describe a new case of pediatric AIS due to a previously unknown atrial myxoma and we conduct a literature review on children with AIS due to cardiac myxoma.<\/jats:p><jats:p>\n          Results\u2003We identified 41 published pediatric cases of AIS and cardiac myxoma, including ours (56% males, median age at AIS was 11 years [range: 3\u201318]). AIS presentation was most frequently with hemiparesis\/hemiplegia (89%). Multiple brain ischemic lesions were detected in 69% of patients, and arteriopathy in 91%. Seven patients underwent mechanical thrombectomy. At AIS presentation, 73% of children had one or more of the following clinical symptoms\/signs suggesting a possible underlying cardiac myxoma: Carney's complex, cardiac auscultation abnormalities, extraneurological symptoms\/signs, such as skin signs (12, 38, and 65%, respectively). Cardiac myxoma was diagnosed within 72\u2009hours in 68% of cases. Death occurred in 11%, and 40% had persistent neurological deficits.<\/jats:p><jats:p>\n          Conclusion\u2003Neurological presentation of AIS due to cardiac myxoma is similar to that of AIS with other etiologies, although clues suggesting a possible underlying cardiac myxoma can be detected in most cases. A timely diagnosis of cardiac myxoma in patients with AIS may favor prompt identification of candidates for endovascular therapy. Therefore, we suggest that in otherwise-healthy children presenting with AIS, transthoracic echocardiography should be performed early after stroke presentation.<\/jats:p>","DOI":"10.1055\/s-0040-1710338","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T18:44:17Z","timestamp":1588704257000},"page":"389-396","source":"Crossref","is-referenced-by-count":13,"title":["Cardiac Myxoma as a Rare Cause of Pediatric Arterial Ischemic Stroke: Case Report and Literature Review"],"prefix":"10.1055","volume":"51","author":[{"given":"Clarissa","family":"Tona","sequence":"first","affiliation":[{"name":"Paediatric Neurology and Neurophysiology Unit, Department of Women's and Children's Health, University Hospital of Padua, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6395-7614","authenticated-orcid":false,"given":"Margherita","family":"Nosadini","sequence":"additional","affiliation":[{"name":"Paediatric Neurology and Neurophysiology Unit, Department of Women's and Children's Health, University Hospital of Padua, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria F.","family":"Pelizza","sequence":"additional","affiliation":[{"name":"Paediatric Neurology and Neurophysiology Unit, Department of Women's and Children's Health, University Hospital of Padua, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacopo N.","family":"Pin","sequence":"additional","affiliation":[{"name":"Paediatric Neurology and Neurophysiology Unit, Department of Women's and Children's Health, University Hospital of Padua, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Baggio","sequence":"additional","affiliation":[{"name":"Paediatric Neurology and Neurophysiology Unit, Department of Women's and Children's Health, University Hospital of Padua, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clementina","family":"Boniver","sequence":"additional","affiliation":[{"name":"Paediatric Neurology and Neurophysiology Unit, Department of Women's and Children's Health, University Hospital of Padua, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph D.","family":"Gabrieli","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit, University Hospital of Padua, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Causin","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit, University Hospital of Padua, Padova, 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