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L\u00f6fgren's syndrome is a subset within the spectrum of sarcoidosis phenotypes, composed of acute onset of fever, bilateral hilar lymphadenopathy, erythema nodosum and\/or bilateral ankle periarticular inflammation\/arthritis, specifically characterized by a self-limiting disease course. In contrast, advanced fibrotic sarcoidosis with pulmonary hypertension phenotype is correlated with a poor prognosis. Further studies are necessary to detail phenotypes to better understand the mechanisms of the disease and plan future clinical therapeutic studies.<\/jats:p>","DOI":"10.1055\/s-0040-1710371","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T22:35:42Z","timestamp":1597098942000},"page":"733-740","source":"Crossref","is-referenced-by-count":6,"title":["Nonlife-Threatening Sarcoidosis"],"prefix":"10.1055","volume":"41","author":[{"given":"Marina Dornfeld Cunha","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Respiratory Diseases, Interstitial Lung Diseases Center, Federal University of S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Alberto de Castro","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Respiratory Diseases, Interstitial Lung Diseases Center, Federal University of S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,8,10]]},"reference":[{"issue":"02","key":"ref1","first-page":"736","article-title":"Joint Statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999","volume":"160","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1164\/rccm.201006-0865CI","article-title":"A concise review of pulmonary sarcoidosis","volume":"183","author":"R P Baughman","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"issue":"04","key":"ref3","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.ccm.2015.08.003","article-title":"The diagnosis of sarcoidosis","volume":"36","author":"P Govender","year":"2015","journal-title":"Clin Chest Med"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.mcna.2005.02.006","article-title":"Sarcoidosis","volume":"89","author":"C E Cox","year":"2005","journal-title":"Med Clin North Am"},{"key":"ref5","first-page":"1","article-title":"Definition and history of sarcoidosis","volume":"32","author":"O Sharma","year":"2005","journal-title":"Eur Respir Mon."},{"issue":"03","key":"ref6","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1055\/s-0034-1381229","article-title":"Clinical presentation of sarcoidosis and diagnostic work-up","volume":"35","author":"D Valeyre","year":"2014","journal-title":"Semin Respir Crit Care Med"},{"issue":"05","key":"ref7","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1097\/MCP.0000000000000077","article-title":"Clinical phenotypes in sarcoidosis","volume":"20","author":"C A Pereira","year":"2014","journal-title":"Curr Opin Pulm Med"},{"issue":"208","key":"ref8","first-page":"525","article-title":"Prognostic factors predicting the outcome of sarcoidosis: an analysis of 818 patients","volume":"52","author":"E Neville","year":"1983","journal-title":"Q J Med"},{"key":"ref9","first-page":"257","volume-title":"Sarcoidosis-associated disability","author":"D Marjolein","year":"2019"},{"issue":"02","key":"ref10","first-page":"90","article-title":"Endpoints for clinical trials of sarcoidosis","volume":"29","author":"R P Baughman","year":"2012","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"issue":"01","key":"ref11","doi-asserted-by":"crossref","first-page":"1800050","DOI":"10.1183\/13993003.00050-2018","article-title":"It's time to evolve from Scadding: phenotyping sarcoidosis","volume":"51","author":"D A Culver","year":"2018","journal-title":"Eur Respir J"},{"issue":"04","key":"ref12","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1159\/000196341","article-title":"Clinical factors predicting persistence of activity in sarcoidosis: a multivariate analysis of 193 cases","volume":"61","author":"J Ma\u00f1\u00e1","year":"1994","journal-title":"Respiration"},{"issue":"01","key":"ref13","first-page":"15","article-title":"Prognosis of sarcoidosis. 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