{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T22:31:05Z","timestamp":1779143465593,"version":"3.51.4"},"reference-count":41,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ortop (Sao Paulo)"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Resumo<\/jats:title><jats:p>Os sarcomas musculoesquel\u00e9ticos s\u00e3o doen\u00e7as raras que exigem aten\u00e7\u00e3o. Frequentemente, apresentam alto grau de malignidade ao diagn\u00f3stico e se subestimados podem evoluir de forma agressiva local e sistemicamente. Apresentam-se como sarcoma de partes moles e sarcomas \u00f3sseos, sendo os de partes moles quatro a cinco vezes mais comuns. A maioria dos sarcomas de partes moles ocorre nos membros. Os subtipos mais comuns nas crian\u00e7as e adolescentes s\u00e3o o rabdomiossarcoma e o sarcoma sinovial, nos adultos o sarcoma pleom\u00f3rfico indiferenciado, lipossarcoma, leiomiossarcoma, mixofibrossarcoma e sarcoma sinovial; todos de alto grau de malignidade histol\u00f3gica. Muitos sarcomas de partes moles s\u00e3o confundidos com tumores benignos de partes moles, 100 vezes mais comuns, por isso s\u00e3o ressecados sem o planejamento necess\u00e1rio, acarretando em amputa\u00e7\u00e3o de um membro que poderia ter sido preservado. Como em todos os c\u00e2nceres, o fator progn\u00f3stico mais importante \u00e9 a doen\u00e7a metast\u00e1tica. Na sua vig\u00eancia, a taxa de sobrevida global cai em torno de 20 a 30%. As taxas de sobrevida no geral s\u00e3o parecidas entre os sarcomas \u00f3sseos e de partes moles, portanto o sarcoma de partes moles, al\u00e9m de mais prevalente, mostra-se t\u00e3o agressivo quanto os sarcomas \u00f3sseos, por isso merece muita aten\u00e7\u00e3o dos ortopedistas que frequentemente s\u00e3o a primeira linha de atendimento dos portadores destes tumores.<\/jats:p>","DOI":"10.1055\/s-0040-1712136","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T23:26:11Z","timestamp":1601076371000},"page":"419-424","source":"Crossref","is-referenced-by-count":7,"title":["Sarcomas de partes moles nos membros, mais comuns e t\u00e3o graves quanto os sarcomas \u00f3sseos"],"prefix":"10.1055","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5025-0823","authenticated-orcid":false,"given":"Karen","family":"Voltan","sequence":"additional","affiliation":[{"name":"Departamento de Ortopedia e Traumatologia, Faculdade de Ci\u00eancias M\u00e9dicas da Universidade Estadual de Campinas, Campinas, SP, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0830-4602","authenticated-orcid":false,"given":"Andr\u00e9 Mathias","family":"Baptista","sequence":"additional","affiliation":[{"name":"Instituto de Ortopedia e Traumatologia, Hospital das Clinicas, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5176-2369","authenticated-orcid":false,"given":"Maur\u00edcio","family":"Etchebehere","sequence":"additional","affiliation":[{"name":"Departamento de Ortopedia e Traumatologia, Faculdade de Ci\u00eancias M\u00e9dicas da Universidade Estadual de Campinas, Campinas, SP, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,9,25]]},"reference":[{"key":"ref1","first-page":"14","volume-title":"Tumors of soft tissue: Introduction","author":"C DM Fletcher","year":"2013"},{"issue":"12","key":"ref2","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s11912-017-0641-2","article-title":"The Role of Next-Generation Sequencing in Sarcomas: Evolution From Light Microscope to Molecular Microscope","volume":"19","author":"R Groisberg","year":"2017","journal-title":"Curr Oncol Rep"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/jso.24135","article-title":"The importance of surgical margins in retroperitoneal sarcoma","volume":"113","author":"A Kirane","year":"2016","journal-title":"J Surg Oncol"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21551","article-title":"Cancer statistics, 2019","volume":"69","author":"R L Siegel","year":"2019","journal-title":"CA Cancer J Clin"},{"issue":"07","key":"ref5","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1056\/NEJMra041866","article-title":"Soft-tissue sarcomas in adults","volume":"353","author":"M A Clark","year":"2005","journal-title":"N Engl J Med"},{"issue":"02","key":"ref6","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s00223-017-0372-2","article-title":"Biology of Bone Sarcomas and New Therapeutic Developments","volume":"102","author":"H K Brown","year":"2018","journal-title":"Calcif Tissue Int"},{"issue":"05","key":"ref7","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1093\/annonc\/mdp415","article-title":"Increasing incidence rates of soft tissue sarcomas? A population-based epidemiologic study and literature review","volume":"21","author":"C Wibmer","year":"2010","journal-title":"Ann Oncol"},{"issue":"03","key":"ref8","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1080\/17453674.2017.1293441","article-title":"The Scandinavian Sarcoma Group Central Register: 6,000 patients after 25 years of monitoring of referral and treatment of extremity and trunk wall soft-tissue sarcoma","volume":"88","author":"C Trovik","year":"2017","journal-title":"Acta Orthop"},{"issue":"01","key":"ref9","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jos.2016.10.006","article-title":"Statistics of bone sarcoma in Japan: Report from the Bone and Soft Tissue Tumor Registry in Japan","volume":"22","author":"K Ogura","year":"2017","journal-title":"J Orthop Sci"},{"issue":"04","key":"ref10","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.jos.2017.03.017","article-title":"Statistics of soft-tissue sarcoma in Japan: Report from the Bone and Soft Tissue Tumor Registry in Japan","volume":"22","author":"K Ogura","year":"2017","journal-title":"J Orthop Sci"},{"issue":"03","key":"ref11","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1097\/MNM.0000000000000041","article-title":"Evaluation of soft-tissue lesions with (18)F-FDG PET\/CT: initial results of a prospective trial","volume":"35","author":"A L Leal","year":"2014","journal-title":"Nucl Med Commun"},{"issue":"05","key":"ref12","doi-asserted-by":"crossref","first-page":"667","DOI":"10.2106\/00004623-200005000-00007","article-title":"Initial symptoms and clinical features in osteosarcoma and Ewing sarcoma","volume":"82","author":"B Widhe","year":"2000","journal-title":"J Bone Joint Surg Am"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1159\/000447083","article-title":"Sarcomas of Soft Tissue and Bone","volume":"43","author":"A Ferrari","year":"2016","journal-title":"Prog Tumor Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ejca.2016.02.007","article-title":"Prognostic significance of (18)F-FDG PET at diagnosis in patients with soft tissue sarcoma and bone sarcoma; systematic review and meta-analysis","volume":"58","author":"T Kubo","year":"2016","journal-title":"Eur J Cancer"},{"issue":"04","key":"ref15","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1002\/cam4.1931","article-title":"Very long-term survivors among patients with metastatic soft tissue sarcoma","volume":"8","author":"M Carbonnaux","year":"2019","journal-title":"Cancer Med"},{"issue":"11","key":"ref16","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1634\/theoncologist.2016-0498","article-title":"Soft Tissue Sarcomas of the Extremities: Surgical Margins Can Be Close as Long as the Resected Tumor Has No Ink on It","volume":"22","author":"K Harati","year":"2017","journal-title":"Oncologist"},{"key":"ref17","first-page":"123","article-title":"The Significance of a \u201cClose\u201d Margin in Extremity Sarcoma: A Systematic Review","volume":"38","author":"I Hasley","year":"2018","journal-title":"Iowa Orthop J"},{"key":"ref18","first-page":"115","article-title":"Rhabdomyosarcoma in adolescent and young adult patients: current perspectives","volume":"5","author":"D Egas-Bejar","year":"2014","journal-title":"Adolesc Health Med Ther"},{"key":"ref19","first-page":"327","volume-title":"Sarcomas","author":"K Thway","year":"2013"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1477-7819-8-84","article-title":"Highly malignant soft tissue sarcoma of the extremity with a delayed diagnosis","volume":"8","author":"J H Park","year":"2010","journal-title":"World J Surg Oncol"},{"issue":"05","key":"ref21","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/S0748-7983(03)00006-4","article-title":"Delay in diagnosis of soft tissue sarcomas","volume":"29","author":"F Brouns","year":"2003","journal-title":"Eur J Surg Oncol"},{"issue":"02","key":"ref22","doi-asserted-by":"crossref","first-page":"144","DOI":"10.6004\/jnccn.2017.7042","article-title":"The AJCC 8th edition staging system for soft tissue sarcoma of the extremities or trunk: A Cohort study of the SEER database","volume":"16","author":"J MM Cates","year":"2018","journal-title":"J Natl Compr Canc Netw"},{"issue":"10","key":"ref23","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.ejso.2015.05.017","article-title":"If your lump is bigger than a golf ball and growing, think Sarcoma","volume":"41","author":"R Nandra","year":"2015","journal-title":"Eur J Surg Oncol"},{"issue":"11","key":"ref24","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1302\/0301-620X.92B11.24326","article-title":"Earlier diagnosis of bone and soft-tissue tumours","volume":"92","author":"R J Grimer","year":"2010","journal-title":"J Bone Joint Surg Br"},{"key":"ref25","first-page":"22","article-title":"[Soft tissue sarcoma: role of imaging for initial diagnosis and treatment]","volume":"10","author":"S Taieb","year":"2006","journal-title":"Cancer Radiother"},{"issue":"05","key":"ref26","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1007\/s00259-015-3242-z","article-title":"Assessing the role of 18F-FDG PET and 18F-FDG PET\/CT in the diagnosis of soft tissue musculoskeletal malignancies: a systematic review and meta-analysis","volume":"43","author":"E C Etchebehere","year":"2016","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"04","key":"ref27","doi-asserted-by":"crossref","first-page":"7068","DOI":"10.18632\/oncotarget.12548","article-title":"Advances in sarcoma diagnostics and treatment","volume":"8","author":"A R Dancsok","year":"2017","journal-title":"Oncotarget"},{"issue":"09","key":"ref28","doi-asserted-by":"crossref","first-page":"579","DOI":"10.6061\/clinics\/2014(09)01","article-title":"Comparative study of planned and unplanned excisions for the treatment of soft tissue sarcoma of the extremities","volume":"69","author":"C E Hanasilo","year":"2014","journal-title":"Clinics (S\u00e3o Paulo)"},{"issue":"03","key":"ref29","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.ocl.2015.02.009","article-title":"Soft tissue masses for the general orthopedic surgeon","volume":"46","author":"E W Jernigan","year":"2015","journal-title":"Orthop Clin North Am"},{"issue":"04","key":"ref30","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1308\/003588412X13171221590016","article-title":"Early symptoms of bone and soft tissue sarcomas: could they be diagnosed earlier?","volume":"94","author":"A George","year":"2012","journal-title":"Ann R Coll Surg Engl"},{"issue":"05","key":"ref31","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1200\/JCO.1996.14.5.1679","article-title":"Analysis of prognostic factors in 1,041 patients with localized soft tissue sarcomas of the extremities","volume":"14","author":"P WT Pisters","year":"1996","journal-title":"J Clin Oncol"},{"issue":"05","key":"ref32","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1590\/S1807-59322006000500003","article-title":"Synovial sarcoma of the extremities: prognostic factors for 20 nonmetastatic cases and a new histologic grading system with prognostic significance","volume":"61","author":"A M Baptista","year":"2006","journal-title":"Clinics (S\u00e3o Paulo)"},{"issue":"05","key":"ref33","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1590\/1413-785220182605208644","article-title":"Prognostic factors in patients with appendicular myxofibrosarcoma","volume":"26","author":"J P Zum\u00e1rraga","year":"2018","journal-title":"Acta Ortop Bras"},{"issue":"01","key":"ref34","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s13018-019-1120-2","article-title":"Prognostic factors of patients with extremity myxoid liposarcomas after surgery","volume":"14","author":"J Wu","year":"2019","journal-title":"J Orthop Surg Res"},{"issue":"05","key":"ref35","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1093\/jjco\/hyx016","article-title":"Impact of geriatric factors on surgical and prognostic outcomes in elderly patients with soft-tissue sarcoma","volume":"47","author":"Y Tsuda","year":"2017","journal-title":"Jpn J Clin Oncol"},{"issue":"06","key":"ref36","first-page":"3137","article-title":"Analysis of Factors for Predicting Survival in Soft-tissue Sarcoma with Metastatic Disease at Initial Presentation","volume":"37","author":"T Nakamura","year":"2017","journal-title":"Anticancer Res"},{"issue":"01","key":"ref38","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.ocl.2015.08.022","article-title":"Update on Survival in Osteosarcoma","volume":"47","author":"M E Anderson","year":"2016","journal-title":"Orthop Clin North Am"},{"issue":"04","key":"ref39","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.canep.2015.05.001","article-title":"Prognostic factors for survival in patients with high-grade osteosarcoma using the Surveillance, Epidemiology, and End Results (SEER) Program database","volume":"39","author":"K R Duchman","year":"2015","journal-title":"Cancer Epidemiol"},{"issue":"04","key":"ref40","doi-asserted-by":"crossref","first-page":"357","DOI":"10.2217\/fon-2016-0261","article-title":"Novel insights and therapeutic interventions for pediatric osteosarcoma","volume":"13","author":"L Kager","year":"2017","journal-title":"Future Oncol"},{"issue":"05","key":"ref41","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1586\/14737140.2016.1168697","article-title":"Metastatic osteosarcoma: a challenging multidisciplinary treatment","volume":"16","author":"C Meazza","year":"2016","journal-title":"Expert Rev Anticancer Ther"},{"issue":"08","key":"ref42","first-page":"600","article-title":"Tumores \u00f3sseos malignos na crian\u00e7a e no adolescente","volume":"35","author":"C R Macedo","year":"1999","journal-title":"Pediatr Mod"}],"container-title":["Revista Brasileira de Ortopedia"],"original-title":[],"language":"pt","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0040-1712136.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T22:37:16Z","timestamp":1630363036000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0040-1712136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,25]]},"references-count":41,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2021,8,30]]},"published-print":{"date-parts":[[2021,8]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0040-1712136","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0102-3616","1982-4378"],"issn-type":[{"value":"0102-3616","type":"print"},{"value":"1982-4378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,25]]}}}