{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:36:50Z","timestamp":1740148610214,"version":"3.37.3"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T00:00:00Z","timestamp":1595376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ortop (Sao Paulo)"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Resumo<\/jats:title><jats:p>\n          Objetivo\u2003Quantificar a concentra\u00e7\u00e3o urin\u00e1ria do biomarcador telopept\u00eddeo C de liga\u00e7\u00e3o cruzada de col\u00e1geno de tipo II (C-terminal cross-linked telopeptide of type-II collagen, CTX-II) em casos de les\u00e3o isolada do ligamento cruzado anterior (LCA), e comparar as concentra\u00e7\u00f5es observadas nessa popula\u00e7\u00e3o com um grupo controle composto por pacientes sem altera\u00e7\u00f5es metab\u00f3licas no joelho que possam levar \u00e0 degenera\u00e7\u00e3o da cartilagem.<\/jats:p><jats:p>\n          M\u00e9todos\u2003Este \u00e9 um estudo piloto transversal com dois grupos: pacientes com ruptura do LCA e grupo controle (cada grupo era composto por 10 indiv\u00edduos do sexo masculino, com 18 a 35 anos de idade, e \u00edndice de massa corporal inferior a 30\u2009kg\/m2). Nos dois grupos, as concentra\u00e7\u00f5es urin\u00e1rias de um biomarcador relacionado \u00e0 degrada\u00e7\u00e3o do col\u00e1geno de tipo II (CTX-II) foram medidas. No grupo com ruptura do LCA, a rela\u00e7\u00e3o entre o tempo p\u00f3s-les\u00e3o e a quantidade do biomarcador tamb\u00e9m foi analisada.<\/jats:p><jats:p>\n          Resultados\u2003Houve diferen\u00e7as significativas nas concentra\u00e7\u00f5es urin\u00e1rias de CTX-II entre o grupo LCA e o grupo controle (p\u2009=\u20090,009). N\u00e3o foi observada rela\u00e7\u00e3o significativa entre o tempo de les\u00e3o e a quantidade do biomarcador.<\/jats:p><jats:p>\n          Conclus\u00f5es\u2003Pacientes com les\u00e3o do LCA apresentaram maiores concentra\u00e7\u00f5es urin\u00e1rias do biomarcador CTX-II do que aqueles sem les\u00e3o do LCA (p\u2009=\u20090,009). No entanto, n\u00e3o houve correla\u00e7\u00e3o entre a concentra\u00e7\u00e3o desse biomarcador e o tempo decorrido ap\u00f3s a les\u00e3o (p&gt; 0,05).<\/jats:p>","DOI":"10.1055\/s-0040-1712139","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T23:26:08Z","timestamp":1595460368000},"page":"326-332","source":"Crossref","is-referenced-by-count":0,"title":["Avalia\u00e7\u00e3o do biomarcador CTX-II em pacientes com ruptura do ligamento cruzado anterior: Estudo piloto"],"prefix":"10.1055","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5238-7388","authenticated-orcid":false,"given":"Alexandre Pedro","family":"Nicolini","sequence":"additional","affiliation":[{"name":"Departamento de Ortopedia e Traumatologia, Centro de Traumatologia do Esporte, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nacime Salom\u00e3o Barbachan","family":"Mansur","sequence":"additional","affiliation":[{"name":"Departamento de Ortopedia e Traumatologia, Centro de Traumatologia do Esporte, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana Luporini","family":"Dreyfuss","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Biologia Molecular, Departamento de Bioqu\u00edmica, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benno","family":"Ejnisman","sequence":"additional","affiliation":[{"name":"Departamento de Ortopedia e Traumatologia, Centro de Traumatologia do Esporte, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moises","family":"Cohen","sequence":"additional","affiliation":[{"name":"Departamento de Ortopedia e Traumatologia, Centro de Traumatologia do Esporte, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego Costa","family":"Astur","sequence":"additional","affiliation":[{"name":"Departamento de Ortopedia e Traumatologia, Centro de Traumatologia do Esporte, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,7,22]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1177\/0363546516629944","article-title":"Incidence of Anterior Cruciate Ligament Tears and Reconstruction: A 21-Year Population-Based 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