{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:04:40Z","timestamp":1788825880376,"version":"build-2803163510"},"reference-count":19,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"10","license":[{"start":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T00:00:00Z","timestamp":1592524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003Gonadotropin-releasing hormone analogues (GnRH-a) have been used preoperatively before hysteroscopic myomectomy to decrease the size and vascularization of the myomas, but evidence to support this practice is weak. Our objective was to analyze the use of GnRH-a in the reduction of submucous fibroid as a facilitator for surgical hysteroscopy from published clinical trials.<\/jats:p><jats:p>\n          Data sources\u2003Studies from electronic databases (Pubmed, Scielo, EMBASE, Scopus, PROSPERO), published between 1980 and December 2018. The keywords used were fibroid, GnRH analogue, submucous, histeroscopy, histeroscopic resection and their correspondents in Portuguese.<\/jats:p><jats:p>\n          Study selection\u2003The inclusion criteria were controlled trials that evaluated the GnRH-a treatment before hysteroscopic resection of submucous myomas. Four clinical trials were included in the meta-analysis.<\/jats:p><jats:p>\n          Data collection\u2003Two review authors extracted the data without modification of the original data, using the agreed form. We resolved discrepancies through discussion or, if required, we consulted a third person.<\/jats:p><jats:p>\n          Data synthesis\u2003The present meta-analysis included a total of 213 women and showed no statistically significant differences in the use of GnRH-a compared with the control group for complete resection of submucous myoma (relative risk [RR]: 0.94; 95% confidence interval [CI]: 0.80\u20131.11); operative time (mean difference [MD]: - 3.81; 95%CI : - 3.81\u20132.13); fluid absorption (MD: - 65.90; 95%CI: - 9.75\u20132.13); or complications (RR 0.92; 95%CI: 0.18\u20134.82).<\/jats:p><jats:p>\n          Conclusion\u2003The present review did not support the routine preoperative use of GnRH-a prior to hysteroscopic myomectomy. However, it is not possible to determine its inferiority when compared with the other methods due to the heterogeneity of existing studies and the small sample size.<\/jats:p>","DOI":"10.1055\/s-0040-1712446","type":"journal-article","created":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T23:26:58Z","timestamp":1592609218000},"page":"649-658","source":"Crossref","is-referenced-by-count":16,"title":["Use of GnRH Analogues in the Reduction of Submucous Fibroid for Surgical Hysteroscopy: A Systematic Review and Meta-Analysis"],"prefix":"10.61622","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2302-9696","authenticated-orcid":false,"given":"Thayane Delazari","family":"Corr\u00eaa","sequence":"additional","affiliation":[{"name":"Ginecology Department, Hospital das Cl\u00ednicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8189-7953","authenticated-orcid":false,"given":"Isabela Maciel","family":"Caetano","sequence":"additional","affiliation":[{"name":"Ginecology Department, Hospital das Cl\u00ednicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6271-2802","authenticated-orcid":false,"given":"Pedro Henrique Tannure","family":"Saraiva","sequence":"additional","affiliation":[{"name":"Ginecology Department, Hospital Metropolitano Odilon Behrens, Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maur\u00edcio Bechara","family":"Noviello","sequence":"additional","affiliation":[{"name":"Ginecology Department, Faculdade da Sa\u00fade e Ecologia Humana and Faculdade de Ci\u00eancias M\u00e9dicas de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9506-8187","authenticated-orcid":false,"given":"Adm\u00e1rio Silva","family":"Santos Filho","sequence":"additional","affiliation":[{"name":"Ginecology Department, Hospital das Cl\u00ednicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"47794","published-online":{"date-parts":[[2020,6,19]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.bpobgyn.2008.04.002","article-title":"Incidence, aetiology and epidemiology of uterine fibroids","volume":"22","author":"S Okolo","year":"2008","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/s1074-3804(05)80793-5","article-title":"Treatment of submucous fibroids, and outcome of assisted conception","volume":"1","author":"R Narayan","year":"1994","journal-title":"J Am Assoc Gynecol Laparosc"},{"issue":"08","key":"ref3","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1097\/00006254-200108000-00022","article-title":"Fibroids and infertility: a systematic review of the evidence","volume":"56","author":"E A Pritts","year":"2001","journal-title":"Obstet Gynecol Surv"},{"issue":"04","key":"ref4","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/s0029-7844(99)00345-2","article-title":"Sonohysterography in premenopausal women with and without abnormal bleeding","volume":"94","author":"M Clevenger-Hoeft","year":"1999","journal-title":"Obstet Gynecol"},{"issue":"09","key":"ref5","doi-asserted-by":"publisher","first-page":"2592","DOI":"10.1093\/humrep\/13.9.2592","article-title":"Efficacy of preoperative medical treatment in facilitating hysteroscopic endometrial resection, myomectomy and metroplasty: literature review","volume":"13","author":"F Parazzini","year":"1998","journal-title":"Hum Reprod"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"CD000547","DOI":"10.1002\/14651858.CD000547.pub2","article-title":"Preoperative medical therapy before surgery for uterine fibroids","volume":"11","author":"A Lethaby","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"issue":"09","key":"ref7","doi-asserted-by":"publisher","first-page":"2264","DOI":"10.1093\/humrep\/deq188","article-title":"The value of pre-operative treatment with GnRH analogues in women with submucous fibroids: a double-blind, placebo-controlled randomized trial","volume":"25","author":"D Mavrelos","year":"2010","journal-title":"Hum Reprod"},{"issue":"04","key":"ref8","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1016\/j.fertnstert.2009.05.070","article-title":"GnRH analogue treatment before hysteroscopic resection of submucous myomas: a prospective, randomized, multicenter study","volume":"94","author":"L Muzii","year":"2010","journal-title":"Fertil Steril"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.ejogrb.2014.03.009","article-title":"Use of GnRH analogues pre-operatively for hysteroscopic resection of submucous fibroids: a systematic review and meta-analysis","volume":"177","author":"M S Kamath","year":"2014","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref10","volume-title":"Cochrane handbook for systematic reviews of interventions","author":"J P Higgins","year":"2017"},{"key":"ref11","volume-title":"Version 5.3 [software]","year":"2014"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.ejogrb.2015.06.018","article-title":"Three-month treatment with triptorelin, letrozole and ulipristal acetate before hysteroscopic resection of uterine myomas: prospective comparative pilot study","volume":"192","author":"N Bizzarri","year":"2015","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"07","key":"ref13","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.1016\/j.fertnstert.2011.03.079","article-title":"The FIGO classification of causes of abnormal uterine bleeding in the reproductive years","volume":"95","author":"M G Munro","year":"2011","journal-title":"Fertil Steril"},{"issue":"04","key":"ref14","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1016\/j.jmig.2017.11.011","article-title":"Intraoperative effect of preoperative gonadotropin-releasing hormone analogue administration in women undergoing cold loop hysteroscopic myomectomy: a randomized controlled trial","volume":"25","author":"A Favilli","year":"2018","journal-title":"J Minim Invasive Gynecol"},{"issue":"05","key":"ref15","first-page":"736","article-title":"Transcervical hysteroscopic resection of submucous fibroids for abnormal uterine bleeding: results regarding the degree of intramural extension","volume":"82","author":"K Wamsteker","year":"1993","journal-title":"Obstet Gynecol"},{"issue":"05","key":"ref16","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/s0015-0282(97)00335-x","article-title":"An analysis of fluid loss during transcervical resection of submucous myomas","volume":"68","author":"M H Emanuel","year":"1997","journal-title":"Fertil Steril"},{"issue":"01","key":"ref17","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.ejogrb.2009.02.006","article-title":"Leiomyoma pseudocapsule after pre-surgical treatment with gonadotropin-releasing hormone agonists: relationship between clinical features and immunohistochemical changes","volume":"144","author":"M De Falco","year":"2009","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"08","key":"ref18","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1111\/j.0001-6349.2005.00690.x","article-title":"Short-term and long-term results of resectoscopic myomectomy with and without pretreatment with GnRH analogs in premenopausal women","volume":"84","author":"S Campo","year":"2005","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"03","key":"ref19","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/s0015-0282(16)55790-2","article-title":"Role of leuprolide acetate depot in hysteroscopic surgery: a controlled study","volume":"59","author":"A Perino","year":"1993","journal-title":"Fertil Steril"}],"container-title":["Revista Brasileira de Ginecologia e Obstetr\u00edcia \/ RBGO Gynecology and Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journalrbgo.org\/article\/use-of-gnrh-analogues-in-the-reduction-of-submucous-fibroid-for-surgical-hysteroscopy-a-systematic-review-and-meta-analysis\/","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0040-1712446.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T20:52:03Z","timestamp":1721335923000},"score":1,"resource":{"primary":{"URL":"https:\/\/journalrbgo.org\/article\/use-of-gnrh-analogues-in-the-reduction-of-submucous-fibroid-for-surgical-hysteroscopy-a-systematic-review-and-meta-analysis\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,19]]},"references-count":19,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,10,31]]},"published-print":{"date-parts":[[2020,10]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0040-1712446","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0100-7203","1806-9339"],"issn-type":[{"value":"0100-7203","type":"print"},{"value":"1806-9339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,19]]}}}