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Immunosuppression therapy (usually with corticosteroids) has been suggested for the treatment of clinically manifest cardiac sarcoidosis (CS) despite minimal data supporting it. Positron emission tomography imaging is often used to detect active disease and guide immunosuppression. Patients with clinically manifest disease often need device therapy, typically with implantable cardioverter defibrillators (ICDs). The extent of left ventricular dysfunction seems to be the most important predictor of prognosis among patients with clinically manifest CS. In the current era of earlier diagnosis, modern heart failure treatment, and use of ICD therapy, the prognosis from CS is much improved. In a recent Finnish nationwide study, 10-year cardiac survival was 92.5% in 102 patients.<\/jats:p>","DOI":"10.1055\/s-0040-1712535","type":"journal-article","created":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T22:32:23Z","timestamp":1593297143000},"page":"626-640","source":"Crossref","is-referenced-by-count":34,"title":["Cardiac Sarcoidosis"],"prefix":"10.1055","volume":"41","author":[{"given":"David H.","family":"Birnie","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,6,27]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1365-2796.2011.02396.x","article-title":"Diagnosing isolated cardiac sarcoidosis","volume":"270","author":"R Kandolin","year":"2011","journal-title":"J Intern Med"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/pace.12277","article-title":"Prevalence of cardiac sarcoidosis in patients presenting with monomorphic ventricular tachycardia","volume":"37","author":"P B Nery","year":"2014","journal-title":"Pacing Clin Electrophysiol"},{"issue":"08","key":"ref3","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1111\/jce.12401","article-title":"Atrioventricular block as the initial manifestation of cardiac sarcoidosis in middle-aged adults","volume":"25","author":"P B Nery","year":"2014","journal-title":"J Cardiovasc Electrophysiol"},{"issue":"10","key":"ref4","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.amjcard.2015.08.025","article-title":"F-18-fluorodeoxyglucose positron emission tomography-guided sampling of mediastinal lymph nodes in the diagnosis of cardiac sarcoidosis","volume":"116","author":"P Simonen","year":"2015","journal-title":"Am J Cardiol"},{"issue":"07","key":"ref5","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1161\/CIRCULATIONAHA.114.011522","article-title":"Cardiac sarcoidosis: epidemiology, characteristics, and outcome over 25 years in a nationwide study","volume":"131","author":"R Kandolin","year":"2015","journal-title":"Circulation"},{"key":"ref6","first-page":"372","article-title":"Pathological studies on sarcoidosis autopsy. 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