{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:27:05Z","timestamp":1793413625348,"version":"4.5.0"},"reference-count":68,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T00:00:00Z","timestamp":1592870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Dent"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Periodontitis is a common inflammatory periodontal disease affecting a wide range of population all over the world. The causing bacteria releases chemicals which activate the innate immune system to release proin\ufb02ammatory cytokines contributing to more progression. This activates the acquired immune system leading to more progression of periodontitis. As the immune response goes on, released cytokines and chemokines can damage the periodontal ligaments, gingiva, and alveolar bone. There are many types of cytokines and chemokines in periodontitis. Cytokines are peptide mediators who are responsible for cell signaling and communication. Chemokines are a large subfamily of cytokines having the ability to coordinate leukocyte recruitment and activation. This paper is a narrative review of the literature.This review ensures that inflammatory mediators in the case of periodontitis can cause a noticeable damage in the whole apparatus of the periodontium. It causes soft tissue inflammation and bone damage affected by the mediators of both innate and acquired immune system.The inflammatory process is accompanied by large network of cytokines and chemokines. There is high expression of proinflammatory cytokines such as interleukin (IL)-1\u03b1, IL-1\u03b2, IL-6, IL-12, tumor necrosis factor (TNF)-\u03b1, and regulatory cytokines such as IL-4, IL-1(RA) receptor antagonist, IL-10, and induced protein (IP)-10. There is also increased production of cytokines IL-10, IL-12, interferon-\u03b3, IP-10, IL-1RA, and IL-4. Cytokines IL-17, IL-6, IL-1\u03b2, TNF-\u03b1, macrophage colony-stimulating factor, and prostaglandin E2 trigger the osteoclast activity causing bone resorption.<\/jats:p>","DOI":"10.1055\/s-0040-1712718","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T19:26:29Z","timestamp":1592940389000},"page":"483-495","source":"Crossref","is-referenced-by-count":228,"title":["Cytokines and Chemokines in Periodontitis"],"prefix":"10.1055","volume":"14","author":[{"given":"Doaa Elsayed","family":"Ramadan","sequence":"additional","affiliation":[{"name":"Dental Health Science Postgraduate Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ninuk","family":"Hariyani","sequence":"additional","affiliation":[{"name":"Dental Health Science Postgraduate Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia"},{"name":"Department of Dental Public Health, Faculty of Dental Medicine, Universitas Airlangga, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Retno","family":"Indrawati","sequence":"additional","affiliation":[{"name":"Dental Health Science Postgraduate Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rini Devijanti","family":"Ridwan","sequence":"additional","affiliation":[{"name":"Dental Health Science Postgraduate Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indeswati","family":"Diyatri","sequence":"additional","affiliation":[{"name":"Dental Health Science Postgraduate Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, 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Heidari","year":"2019","journal-title":"BMC Oral Health"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1600-051X.2010.01670.x","article-title":"Host-derived diagnostic markers related to soft tissue destruction and bone degradation in periodontitis","volume":"38","author":"N Buduneli","year":"2011","journal-title":"J Clin Periodontol"},{"issue":"08","key":"ref6","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/sj.bdj.2014.299","article-title":"A clinical guide to periodontology: pathology of periodontal disease","volume":"216","author":"A Hasan","year":"2014","journal-title":"Br Dent J"},{"issue":"06","key":"ref7","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1902\/jop.2010.100425","article-title":"Serum cytokine levels in periodontitis patients in relation to the bacterial load","volume":"82","author":"O Andrukhov","year":"2011","journal-title":"J Periodontol"},{"issue":"01","key":"ref8","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1600-0757.1997.tb00194.x","article-title":"Cytokines and prostaglandins in immune homeostasis and tissue destruction in periodontal disease","volume":"14","author":"E Gemmell","year":"1997","journal-title":"Periodontol 2000"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"503754","DOI":"10.1155\/2013\/503754","article-title":"Periodontal disease: linking the primary inflammation to bone loss","volume":"2013","author":"A Di Benedetto","year":"2013","journal-title":"Clin Dev Immunol"},{"issue":"01","key":"ref10","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1128\/MMBR.05015-11","article-title":"Into the eye of the cytokine storm","volume":"76","author":"J R Tisoncik","year":"2012","journal-title":"Microbiol Mol Biol Rev"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"434010","DOI":"10.1155\/2013\/434010","article-title":"Cytokine levels in the serum of healthy subjects","volume":"2013","author":"G Kleiner","year":"2013","journal-title":"Mediators Inflamm"},{"issue":"01","key":"ref12","doi-asserted-by":"crossref","first-page":"540","DOI":"10.2741\/3261","article-title":"Chemokines and chemokine receptors: an overview","volume":"14","author":"R Bonecchi","year":"2009","journal-title":"Front Biosci"},{"issue":"01","key":"ref13","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1600-0757.2010.00353.x","article-title":"Comparison of the clinical features of chronic and aggressive periodontitis","volume":"53","author":"G C Armitage","year":"2010","journal-title":"Periodontol 2000"},{"issue":"02","key":"ref14","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1600-051X.1998.tb02419.x","article-title":"Smith C, Kent RL Jr. Microbial complexes in subgingival plaque","volume":"25","author":"S S Socransky","year":"1998","journal-title":"J Clin Periodontol"},{"issue":"01","key":"ref15","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/omi.12136","article-title":"Aggregatibacter actinomycetemcomitans leukotoxin induces cytosol acidification in LFA-1 expressing immune cells","volume":"31","author":"N Balashova","year":"2016","journal-title":"Mol Oral Microbiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"986264","DOI":"10.1155\/2014\/986264","article-title":"LPS from P. gingivalis and hypoxia increases oxidative stress in periodontal ligament fibroblasts and contributes to periodontitis","volume":"2014","author":"L G\u00f6lz","year":"2014","journal-title":"Mediators Inflamm"},{"issue":"09","key":"ref17","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/j.1600-051X.2011.01753.x","article-title":"P activation in diagnostics of periodontitis and systemic inflammation","volume":"38","author":"T Sorsa","year":"2011","journal-title":"J Clin Periodontol"},{"issue":"06","key":"ref18","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1177\/0022034510363682","article-title":"Aggregatibacter actinomycetemcomitans leukotoxin: from threat to therapy","volume":"89","author":"S C Kachlany","year":"2010","journal-title":"J Dent Res"},{"issue":"02","key":"ref19","doi-asserted-by":"crossref","first-page":"292","DOI":"10.4103\/1305-7456.178294","article-title":"Halitosis: current concepts on etiology, diagnosis and management","volume":"10","author":"U Kapoor","year":"2016","journal-title":"Eur J Dent"},{"issue":"02","key":"ref20","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/odi.12468","article-title":"The role of toll-like receptors in periodontitis","volume":"23","author":"B Song","year":"2017","journal-title":"Oral Dis"},{"issue":"02","key":"ref21","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/jre.12193","article-title":"Lipopolysaccharide-regulated production of bone sialoprotein and interleukin-8 in human periodontal ligament fibroblasts: the role of toll-like receptors 2 and 4 and the MAPK pathway","volume":"50","author":"Y Zhang","year":"2015","journal-title":"J Periodontal Res"},{"issue":"07","key":"ref22","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1902\/jop.2012.120362","article-title":"Induction of toll-like receptor expression by porphyromonas gingivalis","volume":"84","author":"N Wara-aswapati","year":"2013","journal-title":"J Periodontol"},{"issue":"05","key":"ref23","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/sj.cdd.4401850","article-title":"Differentiation, TLR signaling","volume":"13","author":"T Kawai","year":"2006","journal-title":"Cell Death"},{"issue":"04","key":"ref24","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/jcpe.12845","article-title":"Effect of life-course family income trajectories on periodontitis: birth cohort study","volume":"45","author":"H S Schuch","year":"2018","journal-title":"J Clin Periodontol"},{"issue":"06","key":"ref25","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/idj.12317","article-title":"The association between oral hygiene and periodontitis: a systematic review and meta-analysis","volume":"67","author":"A Lertpimonchai","year":"2017","journal-title":"Int Dent J"},{"issue":"01","key":"ref26","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4103\/ejd.ejd_300_16","article-title":"Awareness about the effects of tobacco consumption on oral health and the possibility of smoking behavior among male Saudi schoolchildren","volume":"11","author":"N azir Ashraf M","year":"2017","journal-title":"Eur J Dent"},{"issue":"03","key":"ref27","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1600-0528.1995.tb00220.x","article-title":"Association of lifestyle with periodontal health","volume":"23","author":"T K Sakki","year":"1995","journal-title":"Community Dent Oral Epidemiol"},{"issue":"01","key":"ref28","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1055\/s-0039-1693507","article-title":"Association between psychological stress and periodontitis: a systematic review","volume":"14","author":"M M Castro","year":"2020","journal-title":"Eur J Dent"},{"issue":"01","key":"ref29","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s10266-006-0060-6","article-title":"Periodontal disease and systemic conditions: a bidirectional relationship","volume":"94","author":"J Kim","year":"2006","journal-title":"Odontology"},{"issue":"12","key":"ref30","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1111\/jcpe.12781","article-title":"The innate host response in caries and periodontitis","volume":"44","author":"J Meyle","year":"2017","journal-title":"J Clin Periodontol"},{"issue":"04","key":"ref31","doi-asserted-by":"crossref","first-page":"546","DOI":"10.4103\/1305-7456.195179","article-title":"Gingival crevicular fluid periostin levels in chronic periodontitis patients following nonsurgical periodontal treatment with low-level laser therapy","volume":"10","author":"D Kumaresan","year":"2016","journal-title":"Eur J Dent"},{"key":"ref32","volume-title":"Text Book of Clinical Periodontology and Implant Dentistry","author":"J Lindhe","year":"2003"},{"issue":"02","key":"ref33","first-page":"147","article-title":"Markers of systemic inflammation in periodontal patients: chronic versus aggressive periodontitis. An explorative cross-sectional study","volume":"3","author":"F Cairo","year":"2010","journal-title":"Eur J Oral Implantology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"3238","DOI":"10.1099\/mic.0.029132-0","article-title":"Cleavage of protease-activated receptors on an immortalized oral epithelial cell line by Porphyromonas gingivalis gingipains","volume":"155","author":"R A Giacaman","year":"2009","journal-title":"Microbiology"},{"issue":"05","key":"ref35","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1399-302X.2008.00448.x","article-title":"Immunohistochemical localization of toll-like receptors 1-10 in periodontitis","volume":"23","author":"A Beklen","year":"2008","journal-title":"Oral Microbiol Immunol"},{"issue":"10","key":"ref36","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1111\/j.1600-051X.2012.01933.x","article-title":"Antimicrobial responses of primary gingival cells to Porphyromonas gingivalis","volume":"39","author":"H Dommisch","year":"2012","journal-title":"J Clin Periodontol"},{"issue":"02","key":"ref37","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1600-0765.2009.01217.x","article-title":"Proinflammatory effects of muramyldipeptide on human gingival fibroblasts","volume":"45","author":"I Hosokawa","year":"2010","journal-title":"J Periodontal Res"},{"issue":"10","key":"ref38","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.archoralbio.2013.07.007","article-title":"Gingival fibroblasts from periodontitis patients exhibit inflammatory characteristics in vitro","volume":"58","author":"K J Baek","year":"2013","journal-title":"Arch Oral Biol"},{"issue":"04","key":"ref39","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/omi.12172","article-title":"Tannerella forsythia GroEL induces inflammatory bone resorption and synergizes with interleukin-17","volume":"32","author":"Y J Jung","year":"2017","journal-title":"Mol Oral Microbiol"},{"issue":"04","key":"ref40","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1189\/jlb.3MR0115-011R","article-title":"Role of the endothelial surface layer in neutrophil recruitment","volume":"98","author":"A Marki","year":"2015","journal-title":"J Leukoc Biol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1016\/j.freeradbiomed.2014.10.827","article-title":"Differential activation of neutrophil extracellular traps by specific periodontal bacteria","volume":"75","author":"P White","year":"2014","journal-title":"Free Radic Biol Med"},{"issue":"01","key":"ref42","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1177\/0022034515609097","article-title":"Neutrophil extracellular traps in periodontitis: a web of intrigue","volume":"95","author":"P C White","year":"2016","journal-title":"J Dent Res"},{"issue":"01","key":"ref43","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1177\/1753425915617521","article-title":"Neutrophil proteolytic activation cascades: a possible mechanistic link between chronic periodontitis and coronary heart disease","volume":"22","author":"H Alfakry","year":"2016","journal-title":"Innate Immun"},{"issue":"04","key":"ref44","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1189\/jlb.3VMR1014-468R","article-title":"Neutrophil homeostasis and inflammation: novel paradigms from studying periodontitis","volume":"98","author":"G Hajishengallis","year":"2015","journal-title":"J Leukoc Biol"},{"issue":"01","key":"ref45","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/prd.12105","article-title":"Activation and resolution of periodontal inflammation and its systemic impact","volume":"69","author":"H Hasturk","year":"2015","journal-title":"Periodontol 2000"},{"issue":"09","key":"ref46","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/jcpe.12557","article-title":"Gingival crevicular fluid levels of cytokines\/chemokines in chronic periodontitis: a meta-analysis","volume":"43","author":"A F Stadler","year":"2016","journal-title":"J Clin Periodontol"},{"issue":"01","key":"ref47","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1600-0757.2010.00349.x","article-title":"Immunological differences and similarities between chronic periodontitis and aggressive periodontitis","volume":"53","author":"P J Ford","year":"2010","journal-title":"Periodontol 2000"},{"issue":"11","key":"ref48","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1016\/j.bbamcr.2014.05.014","article-title":"Cytokines and chemokines: at the crossroads of cell signalling and inflammatory disease","volume":"1843","author":"M D Turner","year":"2014","journal-title":"Biochim Biophys Acta"},{"issue":"03","key":"ref49","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/0167-5699(96)80606-2","article-title":"The expanding universe of T-cell subsets: Th1, Th2 and more","volume":"17","author":"T R Mosmann","year":"1996","journal-title":"Immunol Today"},{"issue":"11","key":"ref50","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/ni1254","article-title":"Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages","volume":"6","author":"L E Harrington","year":"2005","journal-title":"Nat Immunol"},{"issue":"04","key":"ref51","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1590\/1678-775720140140","article-title":"Simultaneous analysis of T helper subsets (Th1, Th2, Th9, Th17, Th22, Tfh, Tr1 and Tregs) markers expression in periapical lesions reveals multiple cytokine clusters accountable for lesions activity and inactivity status","volume":"22","author":"A C Araujo-Pires","year":"2014","journal-title":"J Appl Oral Sci"},{"issue":"01","key":"ref52","first-page":"d12","article-title":"Cytokines in acute and chronic inflammation","volume":"2","author":"C A Feghali","year":"1997","journal-title":"Front Biosci"},{"issue":"S 11","key":"ref53","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1600-051X.2010.01671.x","article-title":"How has research into cytokine interactions and their role in driving immune responses impacted our understanding of periodontitis","volume":"38","author":"P M Preshaw","year":"2011","journal-title":"J Clin Periodontol"},{"issue":"03","key":"ref54","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1365-2249.2011.04533.x","article-title":"Immunology in clinic review series; focus on autoinflammatory diseases: update on monogenic autoinflammatory diseases: the role of interleukin (IL)-1 and an emerging role for cytokines beyond IL-1","volume":"167","author":"R Goldbach-Mansky","year":"2012","journal-title":"Clin Exp Immunol"},{"issue":"02","key":"ref55","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/icb.2010.164","article-title":"Mini-review series: focus on chemokines","volume":"89","author":"I Comerford","year":"2011","journal-title":"Immunol Cell Biol"},{"issue":"03","key":"ref56","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/00016357.2018.1521005","article-title":"De Rosa CS, Hasseus B, Jonasson P. Inflammatory profile of chronic apical periodontitis: a literature review","volume":"77","author":"P H Braz-Silva","year":"2019","journal-title":"Acta Odontol Scand"},{"issue":"05","key":"ref57","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/j.1399-302X.2005.00232.x","article-title":"Martins W Jr, Silva JS, Cunha FQ. Differential expression of chemokines and chemokine receptors in inflammatory periapical diseases","volume":"20","author":"T A Silva","year":"2005","journal-title":"Oral Microbiol Immunol"},{"issue":"07","key":"ref58","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/iej.12196","article-title":"The role of IL-6 on apical periodontitis: a systematic review","volume":"47","author":"M M Azuma","year":"2014","journal-title":"Int Endod J"},{"issue":"09","key":"ref59","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0165-6147(98)01247-4","article-title":"Definition, function and pathophysiological significance of chemokine receptors","volume":"19","author":"T N Wells","year":"1998","journal-title":"Trends Pharmacol Sci"},{"issue":"04","key":"ref60","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.joen.2012.11.054","article-title":"Th1 and Th2-like protein balance in human inflammatory radicular cysts and periapical granulomas","volume":"39","author":"C A de Carvalho Fraga","year":"2013","journal-title":"J Endod"},{"issue":"03","key":"ref61","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1902\/jop.2003.74.3.391","article-title":"The contribution of interleukin-1 and tumor necrosis factor to periodontal tissue destruction","volume":"74","author":"D T Graves","year":"2003","journal-title":"J Periodontol"},{"issue":"08","key":"ref62","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1902\/jop.2008.080233","article-title":"Inflammation and bone loss in periodontal disease","volume":"79","author":"D L Cochran","year":"2008","journal-title":"J Periodontol"},{"issue":"07","key":"ref63","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1177\/154405910608500704","article-title":"Inflammation-induced bone remodeling in periodontal disease and the influence of post-menopausal osteoporosis","volume":"85","author":"U H Lerner","year":"2006","journal-title":"J Dent Res"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"W J Boyle","year":"2003","journal-title":"Nature"},{"issue":"04","key":"ref65","first-page":"299","article-title":"Tissue destruction in periodontitis: bacteria or cytokines fault?","volume":"36","author":"A Bascones","year":"2005","journal-title":"Quintessence Int"},{"issue":"03","key":"ref66","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1006\/bbrc.2000.3379","article-title":"Protein expression and functional difference of membrane-bound and soluble receptor activator of NF-kappaB ligand: modulation of the expression by osteotropic factors and cytokines","volume":"275","author":"T Nakashima","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1017\/erm.2013.8","article-title":"Inflammatory mediators in the pathogenesis of periodontitis","volume":"15","author":"T Yucel-Lindberg","year":"2013","journal-title":"Expert Rev Mol Med"},{"issue":"01","key":"ref68","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1055\/s-0039-1688522","article-title":"Efficacy of locally administered 1.2% rosuvastatin gel in patients with periodontitis: a randomized placebo controlled clinical trial","volume":"13","author":"D Chatterjee","year":"2019","journal-title":"Eur J Dent"}],"container-title":["European Journal of Dentistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0040-1712718.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T19:22:43Z","timestamp":1597951363000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0040-1712718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,23]]},"references-count":68,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2020,8,20]]},"published-print":{"date-parts":[[2020,7]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0040-1712718","relation":{},"ISSN":["1305-7456","1305-7464"],"issn-type":[{"value":"1305-7456","type":"print"},{"value":"1305-7464","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,23]]}}}