{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T07:17:46Z","timestamp":1777533466753,"version":"3.51.4"},"reference-count":53,"publisher":"Georg Thieme Verlag KG","issue":"08","funder":[{"name":"Spanish Ministry of Economy, Industry, and Competitiveness, through the Instituto de Salud Carlos III","award":["PI17\/01375"],"award-info":[{"award-number":["PI17\/01375"]}]},{"DOI":"10.13039\/501100012513","name":"CIBERCV","doi-asserted-by":"crossref","award":["CB16\/11\/00385"],"award-info":[{"award-number":["CB16\/11\/00385"]}],"id":[{"id":"10.13039\/501100012513","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Background\u2003The ABC (age, biomarkers, and clinical history)-stroke and ABC-bleeding are biomarker-based scores proposed to predict stroke and bleeding, but non-specificity of biomarkers is common, predicting different clinical events at the same time. We assessed the predictive performance of the ABC-stroke and ABC-bleeding scores, for outcomes beyond ischemic stroke and major bleeding, in a cohort of atrial fibrillation (AF) patients.<\/jats:p><jats:p>Methods\u2003We included AF patients stable on vitamin K antagonists for 6 months. The ABC-stroke and ABC-bleeding were calculated and the predictive values for myocardial infarction (MI), acute heart failure (HF), a composite of cardiovascular events, and all-cause deaths were compared.<\/jats:p><jats:p>Results\u2003We included 1,044 patients (49.2% male; median age 76 [71\u201381] years). During 6.5 (4.3\u20137.9) years, there were 58 (5.6%) MIs, 98 (9.4%) acute HFs, 167 (16%) cardiovascular events, and 418 (40%) all-cause deaths. There were no differences in mean ABC-stroke and ABC-bleeding scores in patients with\/without MI (p\u2009=\u20090.367 and p\u2009=\u20090.286, respectively); both scores were higher in patients with acute HF, cardiovascular events, or death (all p\u2009&lt;\u20090.05). Predictive performances for the ABC-stroke and ABC-bleeding scores were similar, ranging from \u201cpoor\u201d for MI (c-indexes \u223c0.54), \u201cmoderate\u201d for acute HF and cardiovascular events (c-indexes \u223c0.60 and \u223c0.64, respectively), and \u201cgood\u201d for all-cause mortality (c-indexes\u2009&gt;\u20090.70). Clinical usefulness whether assessed by ABC-stroke or ABC-bleeding was similar for various primary endpoints.<\/jats:p><jats:p>Conclusion\u2003In AF patients, the ABC-stroke and ABC-bleeding scores demonstrated similar predictive ability for outcomes beyond stroke and bleeding, including MI, acute HF, a composite of cardiovascular events, and all-cause deaths. This is consistent with nonspecificity of biomarkers that predict \u201csick\u201d patients or poor prognosis overall.<\/jats:p>","DOI":"10.1055\/s-0040-1712914","type":"journal-article","created":{"date-parts":[[2020,6,7]],"date-time":"2020-06-07T22:31:46Z","timestamp":1591569106000},"page":"1200-1207","source":"Crossref","is-referenced-by-count":44,"title":["Predicting Adverse Events beyond Stroke and Bleeding with the ABC-Stroke and ABC-Bleeding Scores in Patients with Atrial Fibrillation: The Murcia AF Project"],"prefix":"10.1055","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4080-6346","authenticated-orcid":false,"given":"Anny","family":"Camelo-Castillo","sequence":"first","affiliation":[{"name":"Department of Cardiology, Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, University of Murcia, Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB-Arrixaca), CIBERCV, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0492-6241","authenticated-orcid":false,"given":"Jos\u00e9 Miguel","family":"Rivera-Caravaca","sequence":"first","affiliation":[{"name":"Department of Cardiology, Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, University of Murcia, Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB-Arrixaca), CIBERCV, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7246-7708","authenticated-orcid":false,"given":"Francisco","family":"Mar\u00edn","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Cl\u00ednico Universitario Virgen de la Arrixaca, University of Murcia, Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB-Arrixaca), CIBERCV, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Vicente","sequence":"additional","affiliation":[{"name":"Department of Hematology and Clinical Oncology, Hospital General Universitario Morales Meseguer, University of Murcia, IMIB-Arrixaca, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-1626","authenticated-orcid":false,"given":"Gregory Y. H.","family":"Lip","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science, Liverpool Heart and Chest Hospital, University of Liverpool, Liverpool, United Kingdom"},{"name":"Department of Clinical Medicine, Aalborg Thrombosis Research Unit, Aalborg University, Aalborg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4945-6602","authenticated-orcid":false,"given":"Vanessa","family":"Rold\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Hematology and Clinical Oncology, Hospital General Universitario Morales Meseguer, University of Murcia, IMIB-Arrixaca, Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,6,7]]},"reference":[{"issue":"14","key":"ref1","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1093\/eurheartj\/ehs469","article-title":"All-cause mortality in 272,186 patients hospitalized 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