{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:47:02Z","timestamp":1793378822762,"version":"4.5.0"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:p>\n            Objective\u2003Prematurity and low birth weight (LBW) are risk factors for increased morbidity and mortality in infants with congenital heart defects (CHDs). We sought to describe survival, inhospital morbidities, and 2-year neurodevelopmental follow-up in LBW infants with CHD.<\/jats:p><jats:p>\n            Study Design\u2003We included infants with birth weight (BW) &lt;2,500\u2009g diagnosed with CHD (except isolated patent ductus arteriosus) admitted January 2013 to March 2016 to a single level-IV academic neonatal intensive care unit. We reported CHD prevalence by BW and gestational age; selected in-hospital morbidities and mortality by infant BW, CHD type, and surgical intervention; and developmental outcomes by Bayley's scales of infant and toddler development, third edition (BSID-III) scores at age 2 years.<\/jats:p><jats:p>\n            Results\u2003Among 420 infants with CHD, 28 (7%) underwent cardiac surgery. Median (25th and 75th percentiles) gestational age was 30 (range: 27\u201333) weeks and BW was 1,258 (range: 870\u20131,853) g. There were 134 of 420 (32%) extremely LBW (&lt;1,000\u2009g) infants, 82 of 420 (20%) were small for gestational age, and 51 of 420 (12%) multiples. Most common diagnosis: atrial septal defect (260\/420, 62%), followed by congenital anomaly of the pulmonary valve (75\/420, 18%). Most common surgical procedure: pulmonary artery banding (5\/28, 18%), followed by the tetralogy of Fallot corrective repair (4\/28, 14%). Survival to discharge was 88% overall and lower among extremely LBW (&lt;1,000 g, 81%) infants and infants undergoing surgery (79%). Comorbidities were common (35%); retinopathy of prematurity and bronchopulmonary dysplasia were most prevalent. BSID-III scores were available on 148 of 176 (84%); any scores &lt;85 were noted in 73 of 148 (49%), with language being most commonly affected.<\/jats:p><jats:p>\n            Conclusion\u2003Among LBW infants with congenital heart disease, hospital mortality varied by BW and cardiac diagnosis.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0040-1712964","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T22:48:20Z","timestamp":1591138100000},"page":"1366-1372","source":"Crossref","is-referenced-by-count":14,"title":["Survival, Morbidities, and Developmental Outcomes among Low Birth Weight Infants with Congenital Heart Defects"],"prefix":"10.1055","volume":"38","author":[{"given":"Mihai","family":"Puia-Dumitrescu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Washington, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura N.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Department of Surgery, Duke University Medical Center, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Duke University Medical Center, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberley","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Duke University Medical Center, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick","family":"Pittman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Duke University Medical Center, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karan R.","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Duke University Medical Center, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William F.","family":"Malcolm","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Duke University Medical Center, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn E.","family":"Gustafson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Duke University Medical Center, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Lodge","sequence":"additional","affiliation":[{"name":"Department of Surgery, Duke University Medical Center, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald N.","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Duke University Medical Center, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph P.","family":"Hornik","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Duke University Medical Center, Durham, North Carolina"},{"name":"Division of Quantitative Sciences, Duke Clinical Research Institute, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,6,2]]},"reference":[{"issue":"12","key":"ref1","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1016\/S0735-1097(02)01886-7","article-title":"The incidence of congenital heart disease","volume":"39","author":"J I Hoffman","year":"2002","journal-title":"J Am Coll Cardiol"},{"issue":"06","key":"ref2","doi-asserted-by":"crossref","first-page":"e833","DOI":"10.1542\/peds.2005-0397","article-title":"Cardiovascular malformations among preterm infants","volume":"116","author":"K 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