{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T15:39:32Z","timestamp":1763480372805,"version":"3.37.3"},"reference-count":32,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"06","license":[{"start":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T00:00:00Z","timestamp":1593475200000},"content-version":"vor","delay-in-days":29,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003To evaluate the performance of the hybrid capture 2 (HC2) high-risk papillomavirus (hrHPV) assay and cytological test in women with previous abnormalities, to detect cervical intraepithelial neoplasia grade 2 or worse (\u2265\u2009CIN 2).<\/jats:p><jats:p>\n          Methods\u2003A cytological test and HC2 (Qiagen, Gaithersburg, Maryland, EUA) for hrHPV were conducted in 359 liquid-based (Sure Path, Becton Dickinson, TriPath Imaging, Burlington, NC, USA) samples collected from women from the Vale do Ribeira Region, during July 2013 and September 2015 with previous cytology classified as atypical squamous cells of undetermined significance (ASC-US), low-grade squamous intraepithelial lesion (LSIL), atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesions (ASC-H), and atypical glandular cells (AGC). The histopathological examination was conducted in 179 women. The performance evaluations were calculated using the \u201cexact\u201d Clopper-Pearson 95% confidence interval (CI) test by MEDCALC (Medcalc Software Ltd, Ostend, Belgium).<\/jats:p><jats:p>\n          Results\u2003The\u2009\u2265\u2009CIN 2 frequency was 11.7% (21\/179). The HC2 for hrHPV and repeat cytology to detect\u2009\u2265\u2009CIN 2 obtained, respectively, a sensitivity of 90.5% (95%CI\u2009=\u200969.6\u201398.8) and 90.5%, (95%CI\u2009=\u200969.6\u201398.8), a specificity of 65.8% (95% CI\u2009=\u200957.9\u201373.2) and 43.7% (95%CI\u2009=\u200935.8\u201351.8), a positive predictive value of 26.0% (95% CI\u2009=\u200921.4\u201331.3) and 17.6%, (95%CI\u2009=\u200914.9\u201320.6), and a negative predictive value of 98.1% (95%CI\u2009=\u200993.3\u201399.5) and 97.2% (95% CI\u2009=\u200990.1\u201399.2).<\/jats:p><jats:p>\n          Conclusion\u2003Hybrid capture 2 for hrHPV improves the performance of the detection of\u2009\u2265\u2009CIN 2, without compromising sensitivity, and provides a greater safety margin to return to the triennial screening of women undergoing follow-up due to previous abnormalities, without underlying\u2009\u2265\u2009CIN 2.<\/jats:p>","DOI":"10.1055\/s-0040-1712992","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T22:45:52Z","timestamp":1593557152000},"page":"340-348","source":"Crossref","is-referenced-by-count":1,"title":["High-risk Human Papillomavirus Testing for Triage of Women with Previous Cytological Abnormalities from the Vale do Ribeira Region"],"prefix":"10.61622","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9808-8642","authenticated-orcid":false,"given":"Sandra","family":"Lorente","sequence":"additional","affiliation":[{"name":"Departamente of Pathological Anatomy, Instituto Adolfo Lutz, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0491-7062","authenticated-orcid":false,"given":"Nat\u00e1lia Coelho Couto de Azevedo","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Departamente of Pathological Anatomy, Instituto Adolfo Lutz, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9432-2921","authenticated-orcid":false,"given":"Daniela","family":"Etlinger-Colonelli","sequence":"additional","affiliation":[{"name":"Departamente of Pathological Anatomy, Instituto Adolfo Lutz, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3232-3413","authenticated-orcid":false,"given":"Rodrigo Albergaria","family":"R\u00e9ssio","sequence":"additional","affiliation":[{"name":"Departamente of Pathological Anatomy, Instituto Adolfo Lutz, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7730-4043","authenticated-orcid":false,"given":"Sonia Maria Pereira de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Departamente of Pathological Anatomy, Instituto Adolfo Lutz, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1746-7593","authenticated-orcid":false,"given":"Regina Maria","family":"Catarino","sequence":"additional","affiliation":[{"name":"Departamente of Pathological Anatomy, Instituto Adolfo Lutz, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"47794","published-online":{"date-parts":[[2020,6,30]]},"reference":[{"issue":"S 03","key":"ref2","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.vaccine.2006.05.117","article-title":"Chapter 9: Clinical applications of HPV testing: a summary of meta-analyses","volume":"24","author":"M Arbyn","year":"2006","journal-title":"Vaccine"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S1470-2045(11)70296-0","article-title":"Human papillomavirus testing for the detection of high-grade cervical intraepithelial neoplasia and cancer: final results of the 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