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Although the mechanisms of hepatic inflammation in NASH remain incompletely understood, emerging literature implicates the proinflammatory environment created by toxic lipid-induced hepatocyte injury, termed lipotoxicity. Interestingly, numerous NASH-promoting kinases in hepatocytes, immune cells, and adipocytes are activated by the lipotoxic insult associated with obesity. In the current review, we discuss recent advances in NASH-promoting kinases as disease mediators and therapeutic targets. The focus of the review is mainly on the mitogen-activated protein kinases including mixed lineage kinase 3, apoptosis signal-regulating kinase 1, c-Jun N-terminal kinase, and p38 MAPK; the endoplasmic reticulum (ER) stress kinases protein kinase RNA-like ER kinase and inositol-requiring protein-1\u03b1; as well as the Rho-associated protein kinase 1. We also discuss various pharmacological agents targeting these stress kinases in NASH that are under different phases of development.<\/jats:p>","DOI":"10.1055\/s-0040-1713115","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T22:42:19Z","timestamp":1591915339000},"page":"346-357","source":"Crossref","is-referenced-by-count":13,"title":["Nonalcoholic Steatohepatitis Promoting Kinases"],"prefix":"10.1055","volume":"40","author":[{"given":"Samar H.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology & Hepatology in the Department of Pediatrics, Medicine Mayo Clinic, Rochester, Minnesota"},{"name":"Division of Gastroenterology & Hepatology in the Department of Medicine Mayo Clinic, Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Hirsova","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology & Hepatology in the Department of Medicine Mayo Clinic, Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harmeet","family":"Malhi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology & Hepatology in the Department of Medicine Mayo Clinic, Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory J.","family":"Gores","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology & Hepatology in the Department of Medicine Mayo Clinic, Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,6,11]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Z M 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