{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:39:09Z","timestamp":1792276749772,"version":"4.4.0"},"reference-count":54,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Background\u2003Portal vein thrombosis (PVT) is the most common thrombotic complication in cirrhosis; however, local risk factors involved in its pathogenesis are still not fully investigated. The aim of the study was to evaluate hemostasis and endothelial damage in the portal vein in patients with cirrhosis and portal hypertension.<\/jats:p><jats:p>Methods\u2003Adult cirrhotics undergoing transjugular intrahepatic portosystemic shunt were consecutively enrolled. Rotational thromboelastometry (ROTEM), dosage of total circulating glycosaminoglycans (GAGs), and endotoxemia levels (lipopolysaccharide [LPS]), along with evaluation of endothelial dysfunction by quantification of circulating endothelial microparticles (MPs), were performed on citrated peripheric and portal venous blood samples from each enrolled patient.<\/jats:p><jats:p>Results\u2003Forty-five cirrhotics were enrolled. ROTEM analysis revealed the presence of a significant heparin-like effect in portal blood (median \u0251 angle NATEM 50\u00b0 vs. HEPTEM 55\u00b0, p\u2009=\u20090.027; median coagulation time NATEM 665\u2009s vs. HEPTEM 585\u2009s, p\u2009=\u20090.006), which was not detected in peripheral blood, and was associated with a higher concentration of circulating GAGs. Even though total annexin V-MP circulating MPs were less concentrated in the splanchnic district, the proportion of MPs of endothelial origin, with respect to annexin V-MP, was significantly increased in the portal district (p\u2009=\u20090.036). LPS concentration was higher in portal (197 pg\/mL) compared with peripheral blood (165 pg\/mL) (p\u2009&lt;\u20090.001).<\/jats:p><jats:p>Conclusion\u2003Evidences of a damage of glycocalyx along with increased concentration of endothelial MPs suggest the presence of a significant endothelial alteration in the portal vein with respect to peripheral veins. Portal site-specific endothelial damage could hamper its antithrombotic properties and may represent an important local risk factor in the pathogenesis of PVT.<\/jats:p>","DOI":"10.1055\/s-0040-1713169","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T22:59:39Z","timestamp":1593557979000},"page":"1173-1181","source":"Crossref","is-referenced-by-count":60,"title":["Endothelial Damage of the Portal Vein is Associated with Heparin-Like Effect in Advanced Stages of Cirrhosis"],"prefix":"10.1055","volume":"120","author":[{"given":"Sarah","family":"Shalaby","sequence":"first","affiliation":[{"name":"Multivisceral Transplant Unit, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Simioni","sequence":"first","affiliation":[{"name":"Hemorrhagic and Thrombotic Diseases Unit, Department of Medicine (DIMED), University of Padua Medical 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Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Cillo","sequence":"additional","affiliation":[{"name":"Hepatobiliary Surgery and Liver Transplantation Unit, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Barbiero","sequence":"additional","affiliation":[{"name":"Institute of Radiology, Department of Medicine, Padua University Hospital, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Battistel","sequence":"additional","affiliation":[{"name":"Institute of Radiology, Department of Medicine, Padua University Hospital, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Zanetto","sequence":"additional","affiliation":[{"name":"Multivisceral Transplant Unit, Department of Surgery, Oncology and Gastroenterology, Padua University 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