{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:44:29Z","timestamp":1791567869040,"version":"4.3.4"},"reference-count":17,"publisher":"Scientific Scholar","issue":"01","license":[{"start":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T00:00:00Z","timestamp":1592179200000},"content-version":"vor","delay-in-days":106,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Lab Physicians"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\nIntroduction\u2003The diagnosis of anemia in pregnancy should be early to prevent complications to mother and baby. It should be simple and safe, and therefore feasibility of reticulocyte parameters may prove beneficial in this regard. Newer reticulocyte parameters have not been studied extensively especially in pregnancy. The present study was conducted to evaluate reticulocyte hemoglobin content (Ret-He), immature reticulocyte fraction, and reticulocyte count and to compare them with serum ferritin, mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH) in assessment anemia in pregnancy.<\/jats:p><jats:p>\nMaterial and Methods\u2003Prospective study included first trimester pregnant females where hemoglobin, MCV, and MCH were categorized and statistically analyzed with serum ferritin and reticulocyte parameters.<\/jats:p><jats:p>\nResults\u2003The study included 155 first trimester pregnant females showing statistical difference in Ret-He between all categories of hemoglobin and MCV (p &lt; 0.05). ROC curve analysis using MCV &lt; 83 fl and MCH &lt;27 pg showed that area under curve for Ret-He at cutoff of 27.8 ng\/mL was 0.93 (95% confidence interval 0.90\u20130.98, sensitivity 93%, specificity 83%). The cutoff of 27.2 ng\/mL Ret-He for the diagnosis of iron deficiency anemia has specificity of 86%, sensitivity 71%, positive predictive value 0.39, and likelihood ratio of 5.1.<\/jats:p><jats:p>\nConclusion\u2003Ret-He is a feasible and easily available parameter which may be helpful in differentiating between microcytic hypochromic and normocytic normochromic anemia along with frank and borderline anemia in first trimester pregnant females. This in turn is essential to initiate an early therapy so as to prevent the maternal and fetal complications.<\/jats:p>","DOI":"10.1055\/s-0040-1713585","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T23:01:58Z","timestamp":1592262118000},"page":"15-19","source":"Crossref","is-referenced-by-count":12,"title":["Role of Reticulocyte Parameters in Anemia of First Trimester Pregnancy: A Single Center Observational Study"],"prefix":"10.25259","volume":"12","author":[{"given":"Utpal","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harish","family":"Chandra","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind Kumar","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaya","family":"Chaturvedi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2020,6,15]]},"reference":[{"key":"ref1","volume-title":"The Global Prevalence of Anaemia in 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Joosten","year":"2013","journal-title":"Eur J Intern Med"},{"issue":"01","key":"ref8","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cll.2014.10.004","article-title":"Clinical utility of reticulocyte parameters","volume":"35","author":"E Piva","year":"2015","journal-title":"Clin Lab Med"},{"issue":"06","key":"ref9","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/ijlh.12906","article-title":"Screening of hereditary spherocytosis and pyruvate kinase deficiency by automated blood count using erythrocytic and reticulocytic parameters","volume":"40","author":"V Bob\u00e9e","year":"2018","journal-title":"Int J Lab Hematol"},{"issue":"12","key":"ref10","first-page":"14","article-title":"Reticulocyte hemoglobin vis-a-vis immature reticulocyte fraction, as the earliest indicator of response to therapy in iron deficiency anemia","volume":"65","author":"S Mehta","year":"2017","journal-title":"J Assoc Physicians 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Parodi","year":"2016","journal-title":"Anemia"},{"issue":"S 01","key":"ref14","first-page":"S31","article-title":"Diagnostic accuracy of reticulocyte hemoglobin content in Thai patients with microcytic red cells as a test for iron deficiency anemia","volume":"10","author":"J Chaipokam","year":"2016","journal-title":"Asian Biomed"},{"issue":"07","key":"ref15","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/vox.12700","article-title":"Applying newer parameter Ret-He (reticulocyte haemoglobin equivalent) to assess latent iron deficiency (LID) in blood donors-study at a tertiary care hospital in India","volume":"113","author":"A K Tiwari","year":"2018","journal-title":"Vox Sang"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12878-018-0131-2","article-title":"The role of haematological indices in predicting early iron deficiency among pregnant women in an urban area of Sri Lanka","volume":"18","author":"M SK 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