{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:58Z","timestamp":1740126838843,"version":"3.37.3"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003This retrospective study investigated the prognosis of patients with pathological N1 (pN1) nonsmall cell lung cancer (NSCLC).<\/jats:p><jats:p>\n          Methods\u2003We included patients with pN1 NSCLC who underwent lobectomy or pneumonectomy with mediastinal lymph node dissection and achieved complete resection (R0) between January 2000 and December 2012. Patients who received neoadjuvant therapy were excluded.<\/jats:p><jats:p>\n          Results\u2003A total of 249 patients were included. The mean age was 63.2 years, and 172 patients were males. Of the 249 patients, 200, 20, and 29 underwent lobectomy, bilobectomy, and pneumonectomy, respectively. The median observation period was 5.5 years. The 5-year overall survival (OS) rate was 64.6% (95% confidence interval: 58.3\u201370.4). Five-year OS rates were 79.8% for positive lymph nodes at station 13 or 14 (n\u2009=\u200957), 59.6% at station 12 (n\u2009=\u200972), 62.7% at station 11 (n\u2009=\u200969), and 56.9% at station 10 (n\u2009=\u200951) (log-rank test; p\u2009=\u20090.016); furthermore, the 5-year OS rate was 75.2% for patients with positive lymph nodes at a single station (n\u2009=\u2009160) and 45.4% for patients with positive lymph nodes at multiple stations (n\u2009=\u200989) (log-rank test; p\u2009&lt;\u20090.001). Five-year cumulative incidences of recurrence were equivalent between patients who received adjuvant chemotherapy and patients who did not (45.9 vs. 55.1%; Gray's test; p\u2009=\u20090.366). Distant recurrence was the most frequent mode of recurrence in both groups (70.8 and 67.3%).<\/jats:p><jats:p>\n          Conclusion\u2003The locations and the number of stations of the positive lymph nodes were identified as prognostic factors in patients with pN1 NSCLC. The primary mode of recurrence was distant recurrence irrespective of postoperative adjuvant chemotherapy.<\/jats:p>","DOI":"10.1055\/s-0040-1713613","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T22:45:15Z","timestamp":1594161915000},"page":"366-372","source":"Crossref","is-referenced-by-count":4,"title":["Surgical Results in Pathological N1 Nonsmall Cell Lung Cancer"],"prefix":"10.1055","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6494-2318","authenticated-orcid":false,"given":"Yukihiro","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaya","family":"Yotsukura","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Motoi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun-ichi","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,7,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"e278S","DOI":"10.1378\/chest.12-2359","article-title":"Treatment of stage I and II non-small cell lung cancer: diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines","volume":"143","author":"J A Howington","year":"2013","journal-title":"Chest"},{"issue":"07","key":"ref2","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1097\/JTO.0b013e31807ec803","article-title":"The IASLC lung cancer staging project: proposals for the revision of the N descriptors in the forthcoming seventh edition of the TNM classification for lung cancer","volume":"2","author":"V W Rusch","year":"2007","journal-title":"J Thorac 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