{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T18:48:57Z","timestamp":1762022937757,"version":"build-2065373602"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T00:00:00Z","timestamp":1593129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Dent"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\nObjectives\u2003The aim of this research was to study the intensity of cytokeratin 17 (CK17) in the parenchymal elements of rat\u2019s submandibular salivary glands subjected to fractionated radiotherapy regimen that used for treatment of head and neck malignancy. <\/jats:p><jats:p>\nMaterials and Methods\u2003Twenty male albino rats were divided into two equal groups (normal and irradiated). The irradiated group received a radiation dose of 5 Grays daily for 5 days using therapeutic X-ray beam. Six months later, submandibular gland was dissected out and prepared for both histological and immunohistochemical studies.<\/jats:p><jats:p>\nResults\u2003Submandibular gland of irradiated group showed two different types of histological alterations. The first alteration showed severe gland atrophy replaced by either fibrous or fatty tissues. In some sections, the gland exhibited proliferating activity in the form of profuse amounts of mitotic figures. Immunohistochemical examination of control glands displayed a mild cytoplasmic expression of CK17 of duct cells as well as serous acini. The staining pattern was either diffused or concentrated at the basal part of the cell with negative expression at its apical part.<\/jats:p><jats:p>\nStatistical Analysis\u2003Expression of CK17 in submandibular gland of irradiated group displayed a highly significant differences (P &lt; 0.001) in both intercalated and striated ducts. Many serous acini displayed a highly significant differences (P &lt; 0.001) whereas, mucous acini were negatively stained.<\/jats:p><jats:p>\nConclusions\u2003The intensity and diffusion of CK17 expression in our results foretell the pathological effect of radiotherapy on the intermediate filaments of salivary gland parenchyma that interfered with production and\/or secretion of saliva leading to xerostomia.<\/jats:p>","DOI":"10.1055\/s-0040-1713705","type":"journal-article","created":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T00:45:22Z","timestamp":1593218722000},"page":"440-447","source":"Crossref","is-referenced-by-count":7,"title":["Distribution of Cytokeratin 17 in the Parenchymal Elements of Rat\u2019s Submandibular Glands Subjected to Fractionated Radiotherapy"],"prefix":"10.1055","volume":"14","author":[{"given":"Sherif S.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Oral Biology and Dental Anatomy, Faculty of Dentistry, Al-Azhar University (Assiut), Egypt and, Umm Al-Qura University, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud A.","family":"Attia","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Faculty of Dentistry, Al-Azhar University, (Assiut), Egypt and Faculty of Applied Medical Science, Al-Baha University, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaa M.","family":"Attia","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Periodontology, Faculty of Dentistry, Al-Azhar University (Assiut), Egypt and Umm Al-Qura University, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reda A.","family":"Nofal","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Faculty of Dentistry, Al-Azhar University (Assiut), Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adel","family":"Fathi","sequence":"additional","affiliation":[{"name":"Department of Pedodontics and Oral Health, Faculty of Dentistry, Al-Azhar University (Cairo), Egypt and Umm Al-Qura University, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,6,26]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jdent.2004.10.009","article-title":"Health benefits of saliva: a review","volume":"33","author":"M W Dodds","year":"2005","journal-title":"J Dent"},{"issue":"12","key":"ref2","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.archoralbio.2007.06.009","article-title":"Saliva as research material: biochemical, physicochemical and practical aspects","volume":"52","author":"R G Schipper","year":"2007","journal-title":"Arch Oral Biol"},{"key":"ref3","first-page":"212","volume-title":"Dry Mouth, the Malevolent Symptom: A Clinical Guide","author":"L Sreebny","year":"2010"},{"key":"ref4","first-page":"6","volume-title":"Fractionated Irradiation of Salivary Glands, Loss and Protection of Function","author":"U Funegard","year":"1995"},{"issue":"02","key":"ref5","doi-asserted-by":"crossref","first-page":"45","DOI":"10.14740\/wjon1021w","article-title":"Acute radiation-induced changes in Sprague-Dawley rat submandibular glands: a histomorphometric analysis","volume":"8","author":"M Krishnan","year":"2017","journal-title":"World J Oncol"},{"issue":"05","key":"ref6","first-page":"343","article-title":"The streaming of the submandibular gland. 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